TY  - JOUR
TI  - Evaluation of enzyme inhibitory and antioxidant activity of some Lamiaceae plants
AB  - Lamiaceae is one of the most widespread families in Turkey. The aim of this study was to determine antialzheimer, antidiabetic, antioxidant and antiobesity activities of ethanol extracts of Lamium purpureum var. purpureum, Origanum onites, Salvia sclarea, S. virgata and Thymus zygioides var. lycaonius. Acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and pancreatic lipase inhibitory activities were tested for the determination of the activity of these extracts. Furthermore, total antioxidant, ferric-reducing antioxidant power, metalchelating and N,N-dimethyl-p-phenylendiamine radical scavenging assays were utilized to screen antioxidant activity. Total phenolic content of the extracts were also calculated. Among the tested extracts, T. zygioides var. lycaonius aerial part extract (85.28 ± 0.89 %) showed the highest inhibitory activity against α-glucosidase. The inhibitory activities of all extracts against α-amylase were lower than 50 %. S. sclarea leaf extract indicated remarkable butyrylcholinesterase inhibition (51.76 ± 1.04 %), but all of the plant extracts were inactive against acetylcholinesterase. The Salvia species showed the highest total antioxidant activity. S. sclarea flower (1.34 ± 0.08) and leaf (1.34 ± 0.08) extracts showed the highest ferric-reducing antioxidant power activities. Our findings indicated that O. onites, S. sclarea, S. virgata, and T. zygioides var. lycaonius extracts showed valuable inhibitory activity and emerged as the sources of possible α-glucosidase inhibitors for future studies
AU  - ORHAN, Nilüfer
AU  - Gök, Hasya Nazlı
AU  - DELİORMAN ORHAN, Didem
AU  - Aslan, Mustafa
AU  - ERDOĞAN ORHAN, İLKAY
DO  - 10.12991/jrp.2019.184
PY  - 2019
JO  - Journal of research in pharmacy (online)
VL  - 23
IS  - 4
SN  - 2630-6344
SP  - 749
EP  - 758
DB  - TRDizin
UR  - http://search/yayin/detay/340042
ER  -