TY  - JOUR
TI  - Role of SNPs of CPTIA and CROT genes in the carnitine-shuttle in coronary artery disease: a case-control study
AB  - Objective: Fatty acid β-oxidation defects can lead to difficulties at covering energy requirement of heart. Thecarnitine-shuttle is responsible for the transfering oflong-chain fatty acids from the internal mitochondrialmembrane. The role of genetic variants of the enzymes inthe carnitine shuttle in coronary artery disease (CAD) hasnot been studied. Therefore, we performed a case-controlstudy investigating the possible relation between theCPTIA-rs3019613 and CROT-rs2214930 gene variationslocated carnitine shuttle and CAD risk.Materials and methods: Study groups were comprisedof 96 CAD patients and 85 controls. CPTIA-rs3019613G > A and CROT-rs2214930 T > C polymorphisms weredetermined by real-time-PCR.Results: The CROT-rs2214930-CC genotype was found tobe associated with decreased HDL-cholesterol (HDL-C) incontrols (p = 0.029). In patients with CPTIA-rs3019613-Aallele, body mass index (BMI) (p = 0.016) and BMI threshold-value (p = 0.030) were found be higher compared tothose with GG-genotype, while HDL-C threshold-value(HDL-C ≤ 0.90 mmol/L) was found to be lower (p = 0.015).Regression analysis confirmed CPTIA-rs3019613-A allelehas a significant relationship with decreased HDL-C(p = 0.009) in patients.Conclusion: Our study indicated that the polymorphismsof the CROT and CPTIA genes related to β-oxidation oflong-chain fatty acids had an important effect on serumHDL-C levels and may be a potential risk for CAD.
AU  - KURNAZ GÖMLEKSİZ, Özlem
AU  - ÇOŞKUNPINAR, Ender
AU  - KANCA, Deniz
AU  - Ozkara, Gulcin
AU  - ÖZTÜRK, OĞUZ
AU  - YILMAZ AYDOĞAN, Hülya
AU  - DEMİRCAN, Aslıhan
AU  - Buğra, Zehra
AU  - Yanar, Fatih
DO  - 10.1515/tjb-2018-0546
PY  - 2019
JO  - Türk Biyokimya Dergisi
VL  - 44
IS  - 6
SN  - 1303-829X
SP  - 822
EP  - 830
DB  - TRDizin
UR  - http://search/yayin/detay/340500
ER  -