TY  - JOUR
TI  - The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury
AB  - Objective: The effects of urapidil in intestinal ischemiareperfusion (IR) model were investigated using histopathological and biochemical methods.Materials and methods: Forty Wistar albino rats weresubjected to sham operation (Group 1), IR (Group 2),IR + dimethyl sulfoxide (Group 3), IR + urapidil 0.5 mg/kg(Group 4), and IR + urapidil 5 mg/kg (Group 5). Levels ofMDA, TAS, TOS, SOD, MPO, NF-κB, caspase-3, and LC3Bwere measured.Results and discussion: The groups 2 and 3 had significantly higher TOS and MPO levels than the sham grouphad (p < 0.001), whereas the TAS and SOD levels weresignificantly lower in Group 2 than in the sham group.In treatment groups, TAS and SOD levels increased,whereas TOS, MPO, and MDA levels decreased comparedto Group 2. Caspase-3 and LC3B immunopositivities wereseen at severe levels in Group 2 and 3. However, Group 4and 5 were found to have lower levels of immunopositivity.Immunopositivity was observed in interstitial areas, peribronchial region, and bronchial epithelial cells. A moderate level of NF-κB immunopositivity was seen in Group 2and 3.Conclusion: Our results show that urapidil is one of theantioxidant agents and protects lung tissue from oxidanteffects of intestinal IR injury.
AU  - Baylan, Hüseyin
AU  - ÇOMAKLI, Selim
AU  - Öztürk, Deniz
AU  - GÜZEL ERDOĞAN, Derya
AU  - POLAT, Elif
AU  - TANYELİ, Ayhan
DO  - 10.1515/tjb-2018-0286
PY  - 2019
JO  - Türk Biyokimya Dergisi
VL  - 44
IS  - 4
SN  - 1303-829X
SP  - 539
EP  - 548
DB  - TRDizin
UR  - http://search/yayin/detay/340527
ER  -