TY  - JOUR
TI  - Cofilin-1 as a potential biomarker to evaluate acute kidney injury
AB  - Abstract: Acute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products. For effective treatment and prevent complications the early diagnosis of AKI is crucial. The current analytes used to diagnose AKI are not adequately sensitive and specific and therefore clinicians need new biomarkers. One of the new promising biomarker candidates of renal injury is cofilin-1. Previously, in our laboratory we isolated cofilin-1 in kidney preservation solution prior to transplantation and attempted to measure serum cofilin-1 in renal transplanted patients. However, cofilin-1 was not accurately measured in serum samples due to the methodological issues. In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.
AU  - Berber, ibrahim
AU  - Yozgatli, Tahir Koray
AU  - İZZETE DERELİOĞLU, Ecenur
AU  - MOLDUR, Derya emel
AU  - UÇAL, Yasemin
AU  - ÜNSAL, İbrahim
AU  - ÖZPINAR, AYSEL
AU  - ÇAKIR, Ülkem
AU  - COŞKUN, Abdurrahman
AU  - Serteser, Mustafa
DO  - 10.1515/tjb-2018-0287
PY  - 2019
JO  - Türk Biyokimya Dergisi
VL  - 44
IS  - 1
SN  - 1303-829X
SP  - 9
EP  - 15
DB  - TRDizin
UR  - http://search/yayin/detay/340546
ER  -