Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats
Yıl: 2019 Cilt: 25 Sayı: 4 Sayfa Aralığı: 343 - 349 Metin Dili: İngilizce DOI: 10.5505/tjtes.2018.77246 İndeks Tarihi: 12-06-2020
Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats
Öz: BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chesttrauma and the utility of endocan as a biomarker of the inflammation process using rats.METHODS: The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment ortrauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] routegroup); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased,whereas the reaction intensity in resveratrol + trauma group was deceased. The mean endocan values of the differed between thegroups (p<0.001). The mean endocan value in the resveratrol + trauma group was higher than that of the other groups.CONCLUSION: Resveratrol exhibited anti-inflammatory and antioxidant effects in lung injury after blunt chest trauma and contributed favorably to the treatment process. We believe that there is a need for further studies on the clinical use of endocan as abiomarker of inflammation in cardiac injury after blunt chest trauma.
Anahtar Kelime: Sıçanlarda künt göğüs travma sonrası oluşan kalp hasarı üzerine resveratrolün tedavi edici etkisinin ve endokanın enflamasyonda bir biyobelirteç olarak potansiyel rolünün değerlendirilmesi
Öz: AMAÇ: Bu çalışma, sıçanlarda künt göğüs travmasına bağlı gelişen kardiyak hasar üzerine resveratrolün terapötik etkisini ve endokanın enflamasyon sürecinde bir biyobelirteç olarak kullanılmasını araştırmıştır. GEREÇ VE YÖNTEM: Sıçanlar randomize olarak aşağıdaki dört gruba ayrıldı (her grupta, n=7): bir kontrol grubu (tedavi veya travma olmadan); travma uygulanan grup (travma grubu); resveratrol grubu (resveratrol, [0.3 mg/kg] intraperitoneal [i.p.] yol grubu yoluyla uygulandı); ve resveratrol + travma grubu (travmanın uygulanmasından 1 saat önce i.p. yolla resveratrol [0.3 mg/kg] verilen). BULGULAR: Travma grubundaki tümör nekroz faktörü-α ve indüklenebilir nitrik oksit sentazın immünreaktivitesi artarken, resveratrol + travma grubundaki reaksiyon şiddeti azaldı. Grupların ortalama endokan değerleri farklıydı (p<0.001). Resveratrol + travma grubundaki ortalama endokan ortalaması diğer gruplardan daha yüksekti. TARTIŞMA: Resveratrol, künt göğüs travması sonrası akciğer hasarında anti-enflamatuvar ve antioksidan etkilere sahip olup tedavi sürecine katkıda bulunmuştur. Künt göğüs travması sonrası oluşan kardiyak hasarda enflamasyonun takibinde endokanın bir biyobelirteç olarak klinik kullanımı ile ilgili daha fazla çalışma yapılması gerektiğine inanıyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Raj P, Louis XL, Thandapilly SJ, Movahed A, Zieroth S, Netticadan T. Potential of resveratrol in the treatment of heart failure. Life Sci 2014;95:63–71. [CrossRef ]
- 2. Raj P, Zieroth S, Netticadan T. An overview of the efficacy of resveratrol in the management of ischemic heart disease. Ann N Y Acad Sci 2015;1348:55–67. [CrossRef ]
- 3. Catalgol B, Batirel S, Taga Y, Ozer NK. Resveratrol: French paradox revisited. Front Pharmacol 2012;3:141. [CrossRef ]
- 4. Zhang HX, Duan GL, Wang CN, Zhang YQ, Zhu XY, Liu YJ. Protective effect of resveratrol against endotoxemia-induced lung injury involves the reduction of oxidative/nitrative stress. Pulm Pharmacol Ther 2014;27:150–5. [CrossRef ]
- 5. Cho S, Namkoong K, Shin M, Park J, Yang E, Ihm J, et al. Cardiovascular Protective Effects and Clinical Applications of Resveratrol. J Med Food 2017;20:323–34. [CrossRef ]
- 6. Robich MP, Osipov RM, Chu LM, Han Y, Feng J, Nezafat R, et al. Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia. Eur J Pharmacol 2011;664:45–53. [CrossRef ]
- 7. O’Leary KA, de Pascual-Teresa S, Needs PW, Bao YP, O’Brien NM, Williamson G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat Res 2004;551:245–54. [CrossRef ]
- 8. Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, et al. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:1263–9. [CrossRef ]
- 9. Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol 2009;297:H1876– 81. [CrossRef ]
- 10. Emet M, Akoz A, Aslan S, Saritas A, Cakir Z, Acemoglu H. Assessment of cardiac injury in patients with blunt chest trauma. Eur J Trauma Emerg Surg 2010;36:441–7. [CrossRef ]
- 11. Demir F, Güzel A, Kat C, Karadeniz C, Akdemir U, Okuyucu A, et al. A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats. Braz J Med Biol Res 2014;47:766–72. [CrossRef ]
- 12. De’Ath HD, Manson J, Davenport R, Glasgow S, Renfrew I, Davies LC, et al. Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines. Shock 2013;39:415–20.
- 13. Balta S, Mikhailidis DP, Demirkol S, Ozturk C, Celik T, Iyisoy A. Endocan: A novel inflammatory indicator in cardiovascular disease? Atherosclerosis 2015;243:339–43. [CrossRef ]
- 14. Yang J, Yang Q, Yu S, Zhang X. Endocan: A new marker for cancer and a target for cancer therapy. Biomed Rep 2015;3:279–83. [CrossRef ]
- 15. Palmiere C, Augsburger M. Endocan measurement for the postmortem diagnosis of sepsis. Leg Med (Tokyo) 2014;16:1–7. [CrossRef ]
- 16. Mikkelsen ME, Shah CV, Scherpereel A, Lanken PN, Lassalle P, Bellamy SL, et al. Lower serum endocan levels are associated with the development of acute lung injury after major trauma. J Crit Care 2012;27:522.e11–7.
- 17. Torun AC, Tutuncu S, Ustun B, Akdemir HU. A Study of the Therapeutic Effects of Resveratrol on Blunt Chest Trauma-Induced Acute Lung Injury in Rats and the Potential Role of Endocan as a Biomarker of Inflammation. Inflammation 2017;40:1803–10. [CrossRef ]
- 18. Raghavendran K, Davidson BA, Helinski JD, Marschke CJ, Manderscheid P, Woytash JA, et al. A rat model for isolated bilateral lung contusion from blunt chest trauma. Anesth Analg 2005;101:1482–9. [CrossRef ]
- 19. Adams EJ, Green JA, Clark AH, Youngson JH. Comparison of different scoring systems for immunohistochemical staining. J Clin Pathol 1999;52:75–7. [CrossRef ]
- 20. True LD. Principles of immunohistochemistry. In: True LD, ed. Atlas of Diagnostic Immunohistopathologhy. NewYork: Gower Medical Publishing; 1990. p. 16–22.
- 21. Zheng H, Guo H, Hong Y, Zheng F, Wang J. The effects of age and resveratrol on the hypoxic preconditioning protection against hypoxia-reperfusion injury: studies in rat hearts and human cardiomyocytes. Eur J Cardiothorac Surg 2015;48:375–81. [CrossRef ]
- 22. Hashemzaei M, Barani AK, Iranshahi M, Rezaee R, Tsarouhas K, Tsatsakis AM, et al. Effects of resveratrol on carbon monoxide-induced cardiotoxicity in rats. Environ Toxicol Pharmacol 2016;46:110–15. [CrossRef ]
- 23. Hranjec T, Swenson BR, Dossett LA, Metzger R, Flohr TR, Popovsky KA, et al. Diagnosis-dependent relationships between cytokine levels and survival in patients admitted for surgical critical care. J Am Coll Surg 2010;210:833–44. [CrossRef ]
- 24. Bradamante S, Barenghi L, Piccinini F, Bertelli AA, De Jonge R, Beemster P, et al. Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism. Eur J Pharmacol 2003;465:115–23. [CrossRef ]
- 25. Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, et al. Nitrative and oxidative stress in toxicology and disease. Toxicol Sci 2009;112:4–16. [CrossRef ]
- 26. Kundi H, Balun A, Cicekcioglu H, Karayigit O, Topcuoglu C, Kilinckaya MF, et al. Admission Endocan Level may be a Useful Predictor for InHospital Mortality and Coronary Severity Index in Patients With STSegment Elevation Myocardial Infarction. Angiology 2017;68:46–51.
- 27. Wang XS, Yang W, Luo T, Wang JM, Jing YY. Serum endocan levels are correlated with the presence and severity of coronary artery disease in patients with hypertension. Genet Test Mol Biomarkers 2015;19:124–7.
- 28. Dogan H, Sarikaya S, Neijmann ST, Uysal E, Yucel N, Ozucelik DN, et al. N-terminal pro-B-type natriuretic peptide as a marker of blunt cardiac contusion in trauma. Int J Clin Exp Pathol. 2015;8:6786–92.
- 29. Cheng H, Fan WZ, Wang SC, Geng J, Zang HL, Shen XH, et al. Prognostic utility of combination of NT-proBNP with high sensitive cTn I in patients with heart failure: Results from retrospective study in an emergency department. Scand J Clin Lab Invest 2016;76:361–7. [CrossRef ]
| APA | ÇAĞLAR TORUN A, TÜTÜNCÜ Ş (2019). Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. , 343 - 349. 10.5505/tjtes.2018.77246 |
| Chicago | ÇAĞLAR TORUN Aysun,TÜTÜNCÜ ŞERİFE Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. (2019): 343 - 349. 10.5505/tjtes.2018.77246 |
| MLA | ÇAĞLAR TORUN Aysun,TÜTÜNCÜ ŞERİFE Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. , 2019, ss.343 - 349. 10.5505/tjtes.2018.77246 |
| AMA | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. . 2019; 343 - 349. 10.5505/tjtes.2018.77246 |
| Vancouver | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. . 2019; 343 - 349. 10.5505/tjtes.2018.77246 |
| IEEE | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş "Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats." , ss.343 - 349, 2019. 10.5505/tjtes.2018.77246 |
| ISNAD | ÇAĞLAR TORUN, Aysun - TÜTÜNCÜ, ŞERİFE. "Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats". (2019), 343-349. https://doi.org/10.5505/tjtes.2018.77246 |
| APA | ÇAĞLAR TORUN A, TÜTÜNCÜ Ş (2019). Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi, 25(4), 343 - 349. 10.5505/tjtes.2018.77246 |
| Chicago | ÇAĞLAR TORUN Aysun,TÜTÜNCÜ ŞERİFE Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi 25, no.4 (2019): 343 - 349. 10.5505/tjtes.2018.77246 |
| MLA | ÇAĞLAR TORUN Aysun,TÜTÜNCÜ ŞERİFE Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi, vol.25, no.4, 2019, ss.343 - 349. 10.5505/tjtes.2018.77246 |
| AMA | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(4): 343 - 349. 10.5505/tjtes.2018.77246 |
| Vancouver | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(4): 343 - 349. 10.5505/tjtes.2018.77246 |
| IEEE | ÇAĞLAR TORUN A,TÜTÜNCÜ Ş "Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats." Ulusal Travma ve Acil Cerrahi Dergisi, 25, ss.343 - 349, 2019. 10.5505/tjtes.2018.77246 |
| ISNAD | ÇAĞLAR TORUN, Aysun - TÜTÜNCÜ, ŞERİFE. "Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats". Ulusal Travma ve Acil Cerrahi Dergisi 25/4 (2019), 343-349. https://doi.org/10.5505/tjtes.2018.77246 |
