TY  - JOUR
TI  - Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats
AB  - BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chesttrauma and the utility of endocan as a biomarker of the inflammation process using rats.METHODS: The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment ortrauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] routegroup); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased,whereas the reaction intensity in resveratrol + trauma group was deceased. The mean endocan values of the differed between thegroups (p<0.001). The mean endocan value in the resveratrol + trauma group was higher than that of the other groups.CONCLUSION: Resveratrol exhibited anti-inflammatory and antioxidant effects in lung injury after blunt chest trauma and contributed favorably to the treatment process. We believe that there is a need for further studies on the clinical use of endocan as abiomarker of inflammation in cardiac injury after blunt chest trauma.
AU  - ÇAĞLAR TORUN, Aysun
AU  - TÜTÜNCÜ, ŞERİFE
DO  - 10.5505/tjtes.2018.77246
PY  - 2019
JO  - Ulusal Travma ve Acil Cerrahi Dergisi
VL  - 25
IS  - 4
SN  - 1306-696X
SP  - 343
EP  - 349
DB  - TRDizin
UR  - http://search/yayin/detay/342017
ER  -