KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ

YÜCEL, Orhan Kemal; BERKER KARAÜZÜM, Sibel; SALİM, Ozan; Iltar, Utku; ÇETIN, ZAFER; Aydin, Cigdem

doi:10.17343/sdutfd.535002

KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ

Çiğdem AYDIN, (Mehmet Akif Ersoy Üniversitesi, Bucak Sağlık Yüksekokulu, Burdur, Türkiye)

Zafer ÇETİN, (Sanko Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep, Türkiye)

Orhan Kemal YÜCEL, (Akdeniz Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Antalya, Türkiye)

Utku ILTAR, (Sağlık Bilimleri Üniversitesi, Antalya Eğitim ve Araştırma Hastanesi, Hematoloji Anabilim Dalı, Antalya, Türkiye)

Ozan SALİM, (Akdeniz Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Antalya, Türkiye)

Sibel BERKER KARAÜZÜM (Akdeniz Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2019 Cilt: 26 Sayı: 3 Sayfa Aralığı: 320 - 327 Metin Dili: Türkçe DOI: 10.17343/sdutfd.535002 İndeks Tarihi: 24-06-2020

KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ

Öz:

AmaçKronik miyeloid lösemi (KML) hastalarında Philadelphia (Ph) kromozomunun yanında, ilave kromozom anomalilerin varlığı hastalık progresyonu ile ilişkiliklonal evrimi göstermektedir. Bu nedenle, geniş hasta serilerinde sitogenetik analiz sonuçlarının değerlendirilmesi, KML hastalarında tanı kadar, hastalığın prognozu açısından da büyük öneme sahiptir.Gereç ve YöntemBu çalışmada, KML tanılı 225 hastanın kemik iliği örneklerinden elde edilmiş sitogenetik ve FISH analiz sonuçları retrospektif olarak incelenmiştir.Bulgular225 hastanın 15’inde (%6,7) klasik Ph kromozomuna ilave kromozomal abnormalite belirlenmiştir. Bu hastalardan 2’sinde minör rota (%0,9), 10’unda majör rota(%4,4) kromozom anomalileri, ayrıca 3 hastada sırasıyla ilave kromozom anomalisi olarak t(8;19), t(5;7) ve 16.kromozomun kaybı gözlenmiştir. İlave kromozomal abnormaliteler içerisinde en yaygın olarak ikinci bir Ph kromozomunun varlığı ve bunu takiben 8 ve 19 numaralı kromozomların trizomisi belirlenmiştir. 225 hastanın 7’sinde (%3,1) ise varyant philadelphia kromozom translokasyonu gösterilmiştir ve bu varyant translokasyonlardan t(X;9;22)( p11.4;q34;q11) ve t(20;9;22)(p13;q34;q11) ise bizim çalışmamızda ilk kez rapor edilmiştir.SonuçÇalışmamızda sonuç olarak, t(9;22) translokasyonuna ilave kromozom abnormalitelerinin ve varyant Ph translokasyonlarının KML kliniği ile ilişkisi ve literatüre göre değerlendirilmesi yapılmıştır.

Anahtar Kelime:

ADDITIONAL CHROMOSOMAL ABNORMALITIES AND VARIANT PHILADEPHIA TRANSLOCATIONS IN NEWLY DIAGNOSED CHRONIC MYELOID LEUKEMIA; A SINGLE CENTER EXPERIENCE

Öz:

Objective In addition to the Philadelphia (Ph) chromosome in patients with chronic myeloid leukemia (CML), the presence of additional chromosomal abnormalities indicates clonal evolution associated with disease progression. Therefore, the evaluation of cytogenetic analysis results in large patient series is of great importance in terms of prognosis of the disease as well as diagnosis in CML patients. Material and Method In this study, cytogenetic and FISH analysis results of bone marrow samples of 225 CML patients were analyzed retrospectively.Results In 15 of 225 patients (6.7%), additional chromosomal abnormalities to classical Ph chromosome were detected. Of these patients, 2 had minor rota (0.9%), 10 had major rota (4.4%) chromosomal anomalies, and 3 had additional chromosomal anomaly t(8;9), t(5; 7) and loss of chromosome 16 were observed. Most commonly, the presence of a second Ph chromosome, followed by the trisomy of chromosomes 8 and 19 was determined among additional chromosomal abnormalities. In 7 of 225 patients (3.1%), variant Philadelphia chromosome translocation was shown and from these variant translocations t(X;9;22)(p11.4;q34;q11) and t(20;9;22)(p13;q34;q11) has been reported for the first time in our study.Conclusion As a result, in our study, the association of additional chromosomal abnormalities and variant Ph translocations with CML clinic and evaluation according to the literature were made.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aydin C, ÇETIN Z, YÜCEL O, Iltar U, SALİM O, BERKER KARAÜZÜM S (2019). KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. , 320 - 327. 10.17343/sdutfd.535002
Chicago	Aydin Cigdem,ÇETIN ZAFER,YÜCEL Orhan Kemal,Iltar Utku,SALİM Ozan,BERKER KARAÜZÜM Sibel KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. (2019): 320 - 327. 10.17343/sdutfd.535002
MLA	Aydin Cigdem,ÇETIN ZAFER,YÜCEL Orhan Kemal,Iltar Utku,SALİM Ozan,BERKER KARAÜZÜM Sibel KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. , 2019, ss.320 - 327. 10.17343/sdutfd.535002
AMA	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. . 2019; 320 - 327. 10.17343/sdutfd.535002
Vancouver	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. . 2019; 320 - 327. 10.17343/sdutfd.535002
IEEE	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S "KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ." , ss.320 - 327, 2019. 10.17343/sdutfd.535002
ISNAD	Aydin, Cigdem vd. "KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ". (2019), 320-327. https://doi.org/10.17343/sdutfd.535002

APA	Aydin C, ÇETIN Z, YÜCEL O, Iltar U, SALİM O, BERKER KARAÜZÜM S (2019). KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 26(3), 320 - 327. 10.17343/sdutfd.535002
Chicago	Aydin Cigdem,ÇETIN ZAFER,YÜCEL Orhan Kemal,Iltar Utku,SALİM Ozan,BERKER KARAÜZÜM Sibel KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 26, no.3 (2019): 320 - 327. 10.17343/sdutfd.535002
MLA	Aydin Cigdem,ÇETIN ZAFER,YÜCEL Orhan Kemal,Iltar Utku,SALİM Ozan,BERKER KARAÜZÜM Sibel KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, vol.26, no.3, 2019, ss.320 - 327. 10.17343/sdutfd.535002
AMA	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2019; 26(3): 320 - 327. 10.17343/sdutfd.535002
Vancouver	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2019; 26(3): 320 - 327. 10.17343/sdutfd.535002
IEEE	Aydin C,ÇETIN Z,YÜCEL O,Iltar U,SALİM O,BERKER KARAÜZÜM S "KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ." Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 26, ss.320 - 327, 2019. 10.17343/sdutfd.535002
ISNAD	Aydin, Cigdem vd. "KRONİK MİYELOİD LÖSEMİDE TANI ANINDA İLAVE KROMOZOMAL ABNORMALİTELER VE VARYANT PHİLADEPHİA TRANSLOKASYONLARI; TEK MERKEZ DENEYİMİ". Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 26/3 (2019), 320-327. https://doi.org/10.17343/sdutfd.535002