Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic

Tuba Aydın, (Ağrı İbrahim Çeçen Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ağrı, Türkiye)
Bayram Yurtvermez, (Ağrı İbrahim Çeçen Üniversitesi, Fen Bilimleri Enstitüsü, Ağrı, Türkiye)
Murat Şentürk, (Ağrı İbrahim Çeçen Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Ağrı, Türkiye)
Cavit Kazaz, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)
Ahmet Çakır (Kilis 7 Aralık Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Kilis, Türkiye)
Records of Natural Products
9 2
Yıl: 2019 Cilt: 13 Sayı: 3 Sayfa Aralığı: 216 - 225 Metin Dili: İngilizce DOI: 10.25135/rnp.102.18.07.329 İndeks Tarihi: 25-06-2020

Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic

Öz:
Tarragon or Dragon's-wort (Artemisia dracunculus L.) is widely used as spice and in traditional medicinein various regions of the world. Inhibitory effects of the n-hexane, dichloromethane, ethanol and methanol extracts ofthe leaves of tarragon on the human carbonic anhydrase (hCA) I and II enzymes were investigated. Dichloromethaneextract exhibited the strongest activity with lowest IC50 value (0.020 and 0.031 μg/mL, respectively). Thechromatographic studies on the dichloromethane extract of tarragon allowed the isolation of six known stronginhibitors of hCA isozymes as trans-anethole, stigmasterol, herniarin, (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide, (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one and 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane. The compound, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane was isolated from tarragon for thefirst time in this study. Among the tested compounds, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane showed thehighest inhibitiory impact on both hCA isozymes. Also its IC50 values were found lower than positive control,acetazolamide.
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APA AYDIN T, YURTVERMEZ B, Senturk M, Kazaz C, ÇAKIR A (2019). Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. , 216 - 225. 10.25135/rnp.102.18.07.329
Chicago AYDIN Tuba,YURTVERMEZ Bayram,Senturk Murat,Kazaz Cavit,ÇAKIR Ahmet Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. (2019): 216 - 225. 10.25135/rnp.102.18.07.329
MLA AYDIN Tuba,YURTVERMEZ Bayram,Senturk Murat,Kazaz Cavit,ÇAKIR Ahmet Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. , 2019, ss.216 - 225. 10.25135/rnp.102.18.07.329
AMA AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. . 2019; 216 - 225. 10.25135/rnp.102.18.07.329
Vancouver AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. . 2019; 216 - 225. 10.25135/rnp.102.18.07.329
IEEE AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A "Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic." , ss.216 - 225, 2019. 10.25135/rnp.102.18.07.329
ISNAD AYDIN, Tuba vd. "Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic". (2019), 216-225. https://doi.org/10.25135/rnp.102.18.07.329
APA AYDIN T, YURTVERMEZ B, Senturk M, Kazaz C, ÇAKIR A (2019). Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. Records of Natural Products, 13(3), 216 - 225. 10.25135/rnp.102.18.07.329
Chicago AYDIN Tuba,YURTVERMEZ Bayram,Senturk Murat,Kazaz Cavit,ÇAKIR Ahmet Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. Records of Natural Products 13, no.3 (2019): 216 - 225. 10.25135/rnp.102.18.07.329
MLA AYDIN Tuba,YURTVERMEZ Bayram,Senturk Murat,Kazaz Cavit,ÇAKIR Ahmet Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. Records of Natural Products, vol.13, no.3, 2019, ss.216 - 225. 10.25135/rnp.102.18.07.329
AMA AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. Records of Natural Products. 2019; 13(3): 216 - 225. 10.25135/rnp.102.18.07.329
Vancouver AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic. Records of Natural Products. 2019; 13(3): 216 - 225. 10.25135/rnp.102.18.07.329
IEEE AYDIN T,YURTVERMEZ B,Senturk M,Kazaz C,ÇAKIR A "Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic." Records of Natural Products, 13, ss.216 - 225, 2019. 10.25135/rnp.102.18.07.329
ISNAD AYDIN, Tuba vd. "Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic". Records of Natural Products 13/3 (2019), 216-225. https://doi.org/10.25135/rnp.102.18.07.329
Sayfa Oluşturulma Tarihi
23-04-2024 12:24

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