Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

KIRMIT, ADNAN; SABUNCU, Tevfik; Uyanikoglu, Ahmet; CİNDOĞLU, Çiğdem; EREL, Ozcan; yıldız, rukiye

doi:10.5152/tjg.2019.18775

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

Ahmet UYANIKOĞLU, (Harran Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Şanlıurfa, Türkiye)

Tevfik SABUNCU, (Harran Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Şanlıurfa, Türkiye)

Rukiye YILDIZ, (Harran Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Şanlıurfa, Türkiye)

Çiğdem CİNDOĞLU, (Harran Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Şanlıurfa, Türkiye)

Adnan KİRMİT, (Harran Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye)

Özcan EREL (Harran Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye)

Turkish Journal of Gastroenterology

0 0

Yıl: 2019 Cilt: 30 Sayı: 10 Sayfa Aralığı: 899 - 902 Metin Dili: İngilizce DOI: 10.5152/tjg.2019.18775 İndeks Tarihi: 16-07-2020

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

Öz:

Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin(IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) wereincluded in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group(224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in theIMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. van Dijk SM, Hallensleben NDL, van Santvoort HC, et al. Dutch Pancreatitis Study Group. Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-32. [CrossRef]
2. Chen HZ, Ji L, Li L, Wang G, Bai XW, Cheng CD, Sun B. Early prediction of infected pancreatic necrosis secondary to necrotizing pancreatitis. Medicine (Baltimore) 2017; 96: e7487. [CrossRef]
3. Tamer A, Yaylacı S, Demirsoy H, et al. Akut Pankreatitli Olgularımızın Retrospektif Değerlendirilmesi. (Retrospective Analyses of the Acute Pancreatitis) Sakaryamj 2011; 1: 17-21. [CrossRef]
4. Karatas GA, Kaban I, Aka N, Mentese A, Aker F, Uras AR. The Role of Ischemia Modified Albumin and D-dimer as Early or Late Biochemical Markers in Ovarian Torsion. J Obstet Gynaecol Res 2017; 43: 895-901. [CrossRef]
5. Seshadri Reddy V, Duggina P, Vedhantam M, Manne M, Varma N, Nagaram S. Maternal serum and fetal cord-blood ischemia-modified albumin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2018; 31: 3255-66. [CrossRef]
6. Nazik S, Avci V, Küskü Kiraz Z. Ischemia-modified albumin and other inflammatory markers in the diagnosis of appendicitis in children. UlusTravma Acil Cerrahi Derg 2017; 23: 317-21. [CrossRef]
7. Guntas G, Sahin A, Duran S, et al. Evaluation of Ischemia-Modified Albumin in Patients with Inflammatory Bowel Disease. Clin Lab 2017; 63: 341-7. [CrossRef]
8. Topaloglu N, Kucuk A, Tekin M, et al. Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis. J Coll Physicians Surg Pak 2015; 25: 395-8.
9. Baser H, Can U, Karasoy D, et al. Evaluation of oxidant/anti-oxidants status in patients with mild acute -pancreatitis. Acta Gastroenterol Belg 2016; 79: 23-8.
10. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014; 47: 326-32. [CrossRef]
11. Altiparmak IH, Erkuş ME, Sezen H, et al. The relation of serum thiol levels and thiol/disulphide homeostasis with the severity of coronary artery disease. Kardiol Pol 2016; 74: 1346-53. [CrossRef]
12. Uyanikoglu H, Sak ME, Tatli F, et al. Serum ischemia modified albumin level and its relationship with the thiol/disulfide balance in placenta percreta patients. J Obstet Gynaecol 2018: 38: 1073-7. [CrossRef]
13. Ulusoy S, Ayan NN, Dinc ME, Is A, Bicer C, Erel O. A new oxidative stress marker for thiol-disulphide homeostasis in seasonal allergic rhinitis. Am J Rhinol Allergy 2016; 30: 53-7. [CrossRef]
14. Dertli R, Keskin M, Bıyık M, et al. Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turk J Med Sci 2018; 48: 985-92. [CrossRef]
15. Neselioglu S, Keske PB, Senat AA, et al. The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis. Bratisl Lek Listy 2018; 119: 498-502. [CrossRef]
16. Bopanna S, Nayak B, Prakash S, Shalimar, Mahapatra SJ, Garg PK. Increased oxidative stress and deficient antioxidant levels may be involved in the pathogenesis of idiopathic recurrent acute pancreatitis. Pancreatology 2017; 17: 529-33. [CrossRef]
17. Soyalp M, Yalcin M, Oter V, Ozgonul A. Investigation of procalcitonin, IL-6, oxidative stress index (OSI) plasma and tissue levels in experimental mild and severe pancreatitis in rats. Bratisl Lek Listy 2017; 118: 137-41. [CrossRef]
18. Köseoğlu H, Alışık M, Başaran M, et al. Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turk J Gastroenterol 2018; 29: 348-53. [CrossRef]
19. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000; 19: 311-5. [CrossRef]
20. Sahu B, Abbey P, Anand R, Kumar A, Tomer S, Malik E. Severity assessment of acute pancreatitis using CT severity index and modified CT severity index: Correlation with clinical outcomes and severity grading as per the Revised Atlanta Classification. Indian J Radiol Imaging 2017; 27: 152-60. [CrossRef]
21. McPherson SJ, O’Reilly DA, Sinclair MT, Smith N. The use of imaging in acute pancreatitis in United Kingdom hospitals: findings from a national quality of care study. Br J Radiol 2017: 20170224. [CrossRef]

APA	Uyanikoglu A, SABUNCU T, yıldız r, CİNDOĞLU Ç, KIRMIT A, EREL O (2019). Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. , 899 - 902. 10.5152/tjg.2019.18775
Chicago	Uyanikoglu Ahmet,SABUNCU Tevfik,yıldız rukiye,CİNDOĞLU Çiğdem,KIRMIT ADNAN,EREL Ozcan Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. (2019): 899 - 902. 10.5152/tjg.2019.18775
MLA	Uyanikoglu Ahmet,SABUNCU Tevfik,yıldız rukiye,CİNDOĞLU Çiğdem,KIRMIT ADNAN,EREL Ozcan Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. , 2019, ss.899 - 902. 10.5152/tjg.2019.18775
AMA	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. . 2019; 899 - 902. 10.5152/tjg.2019.18775
Vancouver	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. . 2019; 899 - 902. 10.5152/tjg.2019.18775
IEEE	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O "Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis." , ss.899 - 902, 2019. 10.5152/tjg.2019.18775
ISNAD	Uyanikoglu, Ahmet vd. "Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis". (2019), 899-902. https://doi.org/10.5152/tjg.2019.18775

APA	Uyanikoglu A, SABUNCU T, yıldız r, CİNDOĞLU Ç, KIRMIT A, EREL O (2019). Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology, 30(10), 899 - 902. 10.5152/tjg.2019.18775
Chicago	Uyanikoglu Ahmet,SABUNCU Tevfik,yıldız rukiye,CİNDOĞLU Çiğdem,KIRMIT ADNAN,EREL Ozcan Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology 30, no.10 (2019): 899 - 902. 10.5152/tjg.2019.18775
MLA	Uyanikoglu Ahmet,SABUNCU Tevfik,yıldız rukiye,CİNDOĞLU Çiğdem,KIRMIT ADNAN,EREL Ozcan Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology, vol.30, no.10, 2019, ss.899 - 902. 10.5152/tjg.2019.18775
AMA	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology. 2019; 30(10): 899 - 902. 10.5152/tjg.2019.18775
Vancouver	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology. 2019; 30(10): 899 - 902. 10.5152/tjg.2019.18775
IEEE	Uyanikoglu A,SABUNCU T,yıldız r,CİNDOĞLU Ç,KIRMIT A,EREL O "Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis." Turkish Journal of Gastroenterology, 30, ss.899 - 902, 2019. 10.5152/tjg.2019.18775
ISNAD	Uyanikoglu, Ahmet vd. "Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis". Turkish Journal of Gastroenterology 30/10 (2019), 899-902. https://doi.org/10.5152/tjg.2019.18775