TY  - JOUR
TI  - Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis
AB  - Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin(IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) wereincluded in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group(224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in theIMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
AU  - KIRMIT, ADNAN
AU  - SABUNCU, Tevfik
AU  - Uyanikoglu, Ahmet
AU  - CİNDOĞLU, Çiğdem
AU  - EREL, Ozcan
AU  - yıldız, rukiye
DO  - 10.5152/tjg.2019.18775
PY  - 2019
JO  - Turkish Journal of Gastroenterology
VL  - 30
IS  - 10
SN  - 1300-4948
SP  - 899
EP  - 902
DB  - TRDizin
UR  - http://search/yayin/detay/350951
ER  -