Background/Aims: The Social Security System of our country reimburses only paritaprevir, ritonavir, ombitasvir, and dasabuvir (PrOD)regime in treatment-naive patients with hepatitis C regardless of kidney disease. Most of our renal transplant (RT) recipients were treated with PrOD. The aim of the present study was to investigate the efficacy and safety of PrOD in RT patients with hepatitis C virus (HCV)infection in a single center real-life experience.Materials and Methods: RT recipients with a post-transplant follow-up of at least 1 year were included in the study. The patients weretreated and monitored according to the guidelines. Blood levels of immunosuppressive patients were closely followed up and adjusted.Results: A total of 21 (12 male and nine female) patients were assessed. The age of the patients was 50.8±8.5 years. Ten patients wereinfected with G1a, 10 patients with G1b, and one patient with G4 HCV. Two patients had compensated cirrhosis. Eighteen patientswere treatment-naive, and three were peginterferon+ribavirin-experienced. Sustained virologic response (SVR12) was achieved in allpatients. None of the patients discontinued the treatment. Cyclosporine (Csa) and tacrolimus (Tac) doses were reduced to once a dayto once a week to maintain the blood level within normal range. The most common adverse effect was anemia in patients receivingribavirin. Renal functions did not change during the treatment period.Conclusion: In this real-life experience, all of the 21 PrOD-treated RT recipients reached SVR12. Tac or Csa serum levels were maintainedwithin the normal range with close monitoring. PrOD regime can be successfully and safely used in RT recipients with HCV infection withclose follow-up.