Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome

yildiz, cennet; Karakurt, Ahmet; YILDIZ, Abdülmelik

doi:10.5543/tkda.2018.33896

Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome

Abdülmelik Yıldız, (Medical Park Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Cennet Yıldız, (TEKDEN Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Ahmet Karakurt (Kafkas Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kars, Türkiye)

Türk Kardiyoloji Derneği Arşivi

7 3

Yıl: 2018 Cilt: 46 Sayı: 3 Sayfa Aralığı: 191 - 196 Metin Dili: İngilizce DOI: 10.5543/tkda.2018.33896 İndeks Tarihi: 22-07-2020

Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome

Öz:

Objective: The aim of the present study was to investigatecardiac autonomic effects in restless leg syndrome (RLS) usingheart rate variability (HRV).Methods: A total of 35 patients with RLS and 35 healthy individualswere enrolled in the study. The severity of RLS symptomswas assessed using the International Restless LegsSyndrome Study Group rating scale (IRLS). The correlationbetween the severity of RLS symptoms and HRV parametersmeasured on an electrocardiogram was analyzed.Results: There were no statistically significant differences betweenthe 2 groups with respect to age, gender, or body massindex. The mean heart rate was 85±7.1 bpm in the RLS groupcompared with 79.6±5.5 bpm in the control group (p=0.001).The standard deviation (SD) of all normal to normal (NN) intervals(SDNN), the mean of the deviation of 5-minute NN intervalsover the entire recording (SDNN index), and the SD ofthe average NN intervals calculated over a 5-minute period ofthe entire recording (SDANN) were significantly lower in theRLS group compared with the control group (p<0.05 for all).There were no statistically significant differences between the2 groups in the square root of the mean squared differences ofsuccessive NN intervals (RMSSD) and the proportion of adjacentRR intervals differing by >50 milliseconds in the 24-hourrecording (pNN50) values (p=0.119 and p=0.07, respectively).In patients with RLS, the low frequency (LF) power and LF/high frequency (HF) ratio were significantly higher than those inthe control group (2248.6±245.6 vs 712.1±346.3, 10.7±3.7 vs2.9±1.8; p<0.0001 and p<0.0001, respectively). Compared withthe control group, the RLS group had lower values for HF power,but the difference was not statistically significant (p=0.07). Theseverity of RLS symptoms was negatively correlated with theSDNN, SDANN index, and pNN50 (r=-0.453 and p=0.009, r=-0.340 and p=0.046, r=-0.446 and p=0.007, respectively), andpositively correlated with LF power (r=0.681 and p<0.0001).Conclusion: The study data demonstrated that cardiac autonomicimpairment is associated with RLS.

Anahtar Kelime:

Huzursuz bacak sendromlu hastalarda kalp otonom fonksiyonlarının kalp hızı değişkenliği ile incelenmesi

Öz:

Amaç: Bu çalışmada huzursuz bacak sendromlu (HBS) hastalarda kalp hızı değişkenliğini (KHD) inceleyerek kalp otonom fonksiyonlarını araştırmayı amaçladık. Yöntemler: HBS tanısı konulan 35 hasta ve benzer özelliklere sahip 35 sağlıklı birey çalışmaya alındı. HBS semptomlarının şiddeti Uluslararası Huzursuz Bacak Çalışma Grubu Şiddeti Ölçeği kullanılarak değerlendirildi. HBS semptom şiddeti ve KHD parametreleri arasındaki ilişki değerlendirildi. Bulgular: Yaş, cinsiyet veya vücut kitle indeksi açısından iki grup arasında istatistiksel açıdan anlamlı farklılıklar yoktu. HBS grubunda ortalama kalp atım hızı 85±7.1 /dk iken kontrol grubunda 79.6±5.5 /dk idi (p=0.001). Kontrol grubuna göre tüm normal değerler arası aralıkların (NN) standart sapması (SSNN), tüm kayıt süresince hesaplanmış 5-dakikalık NN aralıklarının ortalama sapması (SSNN indeksi) ve yine tüm kayıt süresince bir 5-dakikalık zaman diliminde ortalama NN aralıklarının hesaplanmış SS’si (SSANN) HBS grubunda anlamlı derecede daha düşüktü (tümü için p<0.05). İki grup arasında ardışık NN aralıklarının ortalama kare farklılıklarının kare kökü (RMSSD) ve 24 saatlik kayıt boyunca 50 milisaniyeden daha uzun süre fark eden bitişik RR aralıklarının oranı (pNN50) açısından fark yoktu (sırasıyla, p=0.119 ve p=0.07). HBS hastalarında düşük frekans (DF)/yüksek frekans (YF) oranı kontrol grubuna göre anlamlı derecede daha yüksek idi (sırasıyla, 2248.6±245.6 ve 712.1±346.3, 10.7±3.7 ve 2.9±1.8; p<0.0001 ve p<0.0001). Kontrol grubuyla karşılaştırıldığında HBS grubunda DF güç değerleri daha düşük olmasına rağmen farklılık istatistiksel açıdan anlamlı değildi (p=0.07). HBS semptomlarının şiddet derecesi SDNNN, SDANN indeksi ve pNN50 ile negatif (sırasıyla, r=-0.453 ve p=0.009, r=-0.340 ve p=0.046, r=-0.446 ve p=0.007) ve YF ile pozitif bir korelasyon göstermekteydi (r=0.681 ve p<0.0001). Sonuç: Çalışma verileri kardiyak otonomik bozukluğun HBS ile ilişkili olduğunu göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIZ A, yildiz c, Karakurt A (2018). Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. , 191 - 196. 10.5543/tkda.2018.33896
Chicago	YILDIZ Abdülmelik,yildiz cennet,Karakurt Ahmet Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. (2018): 191 - 196. 10.5543/tkda.2018.33896
MLA	YILDIZ Abdülmelik,yildiz cennet,Karakurt Ahmet Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. , 2018, ss.191 - 196. 10.5543/tkda.2018.33896
AMA	YILDIZ A,yildiz c,Karakurt A Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. . 2018; 191 - 196. 10.5543/tkda.2018.33896
Vancouver	YILDIZ A,yildiz c,Karakurt A Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. . 2018; 191 - 196. 10.5543/tkda.2018.33896
IEEE	YILDIZ A,yildiz c,Karakurt A "Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome." , ss.191 - 196, 2018. 10.5543/tkda.2018.33896
ISNAD	YILDIZ, Abdülmelik vd. "Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome". (2018), 191-196. https://doi.org/10.5543/tkda.2018.33896

APA	YILDIZ A, yildiz c, Karakurt A (2018). Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. Türk Kardiyoloji Derneği Arşivi, 46(3), 191 - 196. 10.5543/tkda.2018.33896
Chicago	YILDIZ Abdülmelik,yildiz cennet,Karakurt Ahmet Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. Türk Kardiyoloji Derneği Arşivi 46, no.3 (2018): 191 - 196. 10.5543/tkda.2018.33896
MLA	YILDIZ Abdülmelik,yildiz cennet,Karakurt Ahmet Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. Türk Kardiyoloji Derneği Arşivi, vol.46, no.3, 2018, ss.191 - 196. 10.5543/tkda.2018.33896
AMA	YILDIZ A,yildiz c,Karakurt A Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. Türk Kardiyoloji Derneği Arşivi. 2018; 46(3): 191 - 196. 10.5543/tkda.2018.33896
Vancouver	YILDIZ A,yildiz c,Karakurt A Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome. Türk Kardiyoloji Derneği Arşivi. 2018; 46(3): 191 - 196. 10.5543/tkda.2018.33896
IEEE	YILDIZ A,yildiz c,Karakurt A "Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome." Türk Kardiyoloji Derneği Arşivi, 46, ss.191 - 196, 2018. 10.5543/tkda.2018.33896
ISNAD	YILDIZ, Abdülmelik vd. "Assessment of cardiac autonomic functions by heart rate variability in patients with restless leg syndrome". Türk Kardiyoloji Derneği Arşivi 46/3 (2018), 191-196. https://doi.org/10.5543/tkda.2018.33896