Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia

TOKGÖZ AKYIL, Fatma; Agir, Ahmet Riza; Turker, Hatice; ALPARSLAN BEKİR, Sümeyye; Akyıl, Mustafa; GÜNGÖR, Aylin; SÖĞÜT, Gokhan; Sevim, Tulin; ÇOBAN AĞCA, Meltem; OZANTÜRK, Erdal

Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia

Fatma TOKGÖZ AKYIL, (Çanakkale Mehmet Akif Ersoy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Çanakkale, Türkiye)

Mustafa AKYIL, (Çanakkale Mehmet Akif Ersoy Devlet Hastanesi, Göğüs Cerrahisi Kliniği, Çanakkale, Türkiye)

Meltem ÇOBAN AĞCA, (İstanbul Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Aylin GÜNGÖR, (İstanbul Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Erdal OZANTÜRK, (Çanakkale Mehmet Akif Ersoy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Çanakkale, Türkiye)

Gökhan SÖĞÜT, (Çanakkale Mehmet Akif Ersoy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Çanakkale, Türkiye)

Sümeyye ALPARSLAN BEKİR, (İstanbul Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Ahmet TOPBAŞ, (Çanakkale Mehmet Akif Ersoy Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Çanakkale, Türkiye)

Hatice TÜRKER, (İstanbul Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Tülin SEVİM (İstanbul Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Tüberküloz ve Toraks

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Yıl: 2019 Cilt: 67 Sayı: 4 Sayfa Aralığı: 239 - 247 Metin Dili: İngilizce İndeks Tarihi: 30-07-2020

Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia

Öz:

Introduction: Dysnatremia is reported to have a prognostic effect in variousdiseases. A limited number of studies have been published on dysnatremiarelated parameters and clinical outcome in patients with pneumonia. The aimof the study is to analyze the factors related to baseline dysnatremia and toevaluate the clinical outcome of dysnatremia on hospital stay, 30-day and1-year mortality in hospitalized patients with community-acquired pneumonia(CAP).Materials and Methods: The study is a two-centre, retrospective, crosssectional study. According to the baseline corrected sodium values,hospitalized patients with CAP were grouped as hyponatremia (< 135mmol/L), normonatremia (135-145 mmol/L) and hypernatremia (> 145mmol/L).Results: Of all the 471 patients included, 119 (25.3%) had hyponatremia and25 (5.3%) had hypernatremia. Higher leucocytes and lower albumin valuescorrelated with hyponatremia while female gender, higher leucocytes andurea levels correlated with hypernatremia. Baseline hyponatremia prolongedhospital stay (9.2 ± 5.6, vs. 7.5 ± 4.6, respectively, p= 0.001) and increased1-year mortality. On the other hand, hypernatremia predicted 30-day (40%,vs. 10%, p< 0.001) and independently predicted 1-year mortality (p< 0.001).Conclusion: In hospitalized patients with CAP, baseline hyponatremia prolongs hospital stay while hypernatremia signals a worseoutcome both in the short term and long term.

Anahtar Kelime:

Hastanede tedavi edilen toplumda gelişen pnömonide hiponatremi hastane yatışını uzatır ve hipernatremi mortalite için hiponatremiden daha güçlü bir belirteçtir

Öz:

Giriş: Disnatreminin birçok hastalıkta prognostik etkisi olduğu gösterilmiştir. Pnömoni hastalarında disnatremi ile ilişkili faktörler ve klinik önemi ile ilişkili az sayıda çalışma yayınlanmıştır. Bu çalışmanın amacı hastanede tedavi edilen toplumda gelişen pnömoni (TGP) hastalarında disnatremi ile ilişkili faktörleri belirlemek, disnatreminin hastane yatış süresi, kısa ve uzun dönem mortalite ile ilişkisini araştırmaktır. Materyal ve Metod: Çalışma iki merkezli, retrospektif bir çalışmadır. TGP tanısı ile hastanede tedavi başlanan hastalar bazal sodyum değerlerine göre hiponatremi (< 135 mmol/L), normonatremi (135-145 mmol/L) ve hipernatremi (> 145 mmol/L) olarak gruplandırıldı. Bulgular: Çalışmaya dahil edilen 471 hastanın 119 (%25.3)’unda hiponatremi, 25 (%5.3)’inde hipernatremi tespit edildi. Hiponatremi ile yüksek lökosit ve düşük albumin değerlerinin; hipernatremi ile kadın cinsiyet, yüksek lökosit ve üre değerlerinin ilişkili olduğu bulundu. Bazal hiponatreminin hastane yatış süresini uzattığı (9.2 ± 5.6 gün ve 7.5 ± 4.6 gün; sırasıyla, p= 0.001) saptandı. Hipernatreminin bir aylık mortalite riskini artırdığı (%10 vs. %40, p< 0.001) ve bir yıllık mortalite için bağımısz risk faktörü olduğu belirlendi (p< 0.001). Sonuç: Hastanede tedavi edilen TGP hastalarında bazal hiponatremi hastane yatışını uzatan hipernatremi hem kısa hem uzun dönem mortaliteyi artıran belirteçlerdir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TOKGÖZ AKYIL F, Akyıl M, ÇOBAN AĞCA M, GÜNGÖR A, OZANTÜRK E, SÖĞÜT G, ALPARSLAN BEKİR S, Agir A, Turker H, Sevim T (2019). Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. , 239 - 247.
Chicago	TOKGÖZ AKYIL Fatma,Akyıl Mustafa,ÇOBAN AĞCA Meltem,GÜNGÖR Aylin,OZANTÜRK Erdal,SÖĞÜT Gokhan,ALPARSLAN BEKİR Sümeyye,Agir Ahmet Riza,Turker Hatice,Sevim Tulin Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. (2019): 239 - 247.
MLA	TOKGÖZ AKYIL Fatma,Akyıl Mustafa,ÇOBAN AĞCA Meltem,GÜNGÖR Aylin,OZANTÜRK Erdal,SÖĞÜT Gokhan,ALPARSLAN BEKİR Sümeyye,Agir Ahmet Riza,Turker Hatice,Sevim Tulin Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. , 2019, ss.239 - 247.
AMA	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. . 2019; 239 - 247.
Vancouver	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. . 2019; 239 - 247.
IEEE	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T "Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia." , ss.239 - 247, 2019.
ISNAD	TOKGÖZ AKYIL, Fatma vd. "Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia". (2019), 239-247.

APA	TOKGÖZ AKYIL F, Akyıl M, ÇOBAN AĞCA M, GÜNGÖR A, OZANTÜRK E, SÖĞÜT G, ALPARSLAN BEKİR S, Agir A, Turker H, Sevim T (2019). Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. Tüberküloz ve Toraks, 67(4), 239 - 247.
Chicago	TOKGÖZ AKYIL Fatma,Akyıl Mustafa,ÇOBAN AĞCA Meltem,GÜNGÖR Aylin,OZANTÜRK Erdal,SÖĞÜT Gokhan,ALPARSLAN BEKİR Sümeyye,Agir Ahmet Riza,Turker Hatice,Sevim Tulin Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. Tüberküloz ve Toraks 67, no.4 (2019): 239 - 247.
MLA	TOKGÖZ AKYIL Fatma,Akyıl Mustafa,ÇOBAN AĞCA Meltem,GÜNGÖR Aylin,OZANTÜRK Erdal,SÖĞÜT Gokhan,ALPARSLAN BEKİR Sümeyye,Agir Ahmet Riza,Turker Hatice,Sevim Tulin Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. Tüberküloz ve Toraks, vol.67, no.4, 2019, ss.239 - 247.
AMA	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. Tüberküloz ve Toraks. 2019; 67(4): 239 - 247.
Vancouver	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia. Tüberküloz ve Toraks. 2019; 67(4): 239 - 247.
IEEE	TOKGÖZ AKYIL F,Akyıl M,ÇOBAN AĞCA M,GÜNGÖR A,OZANTÜRK E,SÖĞÜT G,ALPARSLAN BEKİR S,Agir A,Turker H,Sevim T "Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia." Tüberküloz ve Toraks, 67, ss.239 - 247, 2019.
ISNAD	TOKGÖZ AKYIL, Fatma vd. "Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia". Tüberküloz ve Toraks 67/4 (2019), 239-247.