TY  - JOUR
TI  - Atherogenic index of plasma as a cardiovascular risk marker in manic, depressive, and euthymic stages of bipolar disorder
AB  - Objective: Individuals with bipolar disorder (BD) frequentlysuffer from cardiovascular disease (CVD), and it is a leadingcause of mortality. Clinicians use routine laboratory tests, including a lipid profile, to predict cardiovascular risk. In addition,a particular lipid ratio, the atherogenic index of plasma (AIP),is a sensitive, new parameter that can be used to assess highrisk groups. To our knowledge, this is the first study evaluatingcardiovascular risk via AIP in different stages of BD.Methods: The study group consisted of male patients withBD who were in a manic, depressive, or euthymic state, andage- and gender-matched healthy controls. Lipid profiles wereanalyzed and the AIP parameter of logarithm of triglyceride(TG) / high-density lipoprotein cholesterol (HDLc) was calculated for all of the participants. The significance level was setat p<0.05.Results: A total of 44 BD patients experiencing a manicepisode, 35 depressive BD patients, 42 euthymic patients,and 41 healthy controls matched for age, gender, and smoking status were enrolled in the study. The AIP level was significantly different between groups (p=0.009). Pairwise comparisons of the groups revealed that the AIP level of depressivepatients was significantly higher than that of the manic, euthymic, and control groups (p=0.013, p=0.048, and p=0.021,respectively). The AIP level was positively correlated withbody mass index, waist circumference, metabolic syndrome,total cholesterol, low-density lipoprotein, and triglyceride level,and was negatively correlated with the HDLc level.Conclusion: In this study, male BD patients in a depressiveepisode demonstrated an increase in cardiovascular risk. Thesignificant correlations between AIP and other conventionalcardiovascular risk factors indicate that AIP may be more useful to identify individuals with BD at high risk for CVD thanabsolute lipid parameters.
AU  - Yüksel, Özge
AU  - akkus, mustafa
AU  - KÖK, Burcu
AU  - SÖZEN, Şule
AU  - CİHNİOĞLU, Refik
AU  - KALELİOĞLU, Tevfik
AU  - ÜNALAN, Pelin
AU  - KARAMUSTAFALIOĞLU, Nesrin
DO  - 10.5543/tkda.2017.23350
PY  - 2018
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 46
IS  - 1
SN  - 1016-5169
SP  - 32
EP  - 38
DB  - TRDizin
UR  - http://search/yayin/detay/352899
ER  -