TY  - JOUR
TI  - Assessment of subclinical atherosclerosis in psoriatic arthritis patients without clinically overt cardiovascular disease or traditional atherosclerosis risk factors
AB  - Objective: Cardiovascular disease (CVD) is more prevalentin almost all patients with chronic inflammatory musculoskeletal diseases than in their healthy counterparts. The aim of thisstudy was to assess the presence of subclinical atherosclerosisin patients with psoriatic arthritis (PsA) in comparison with patients with rheumatoid arthritis (RA) and healthy controls.Methods: A total of 30 patients with PsA, 30 patients with RA,and 30 healthy controls were enrolled in this parallel groupstudy. Demographic, clinical, and laboratory data of the groupswere recorded. The Disease Activity Score-28 tool was usedfor joint assessment. The erythrocyte sedimentation rate andC-reactive protein level were measured as acute phase reactants. Flow-mediated dilatation (FMD) and carotid intima mediathickness (CIMT) were also measured in all participants.Results: The median duration of disease in patients withPsA was 60 months (range: 8–216 months). A total of 22 of30 (73.3%) PsA patients had a diagnosis of psoriasis and13 (48.1%) had active disease. The study groups were similar with regard to age, gender, and body mass index data. Inall, 23 (76.7%) of the PsA patients and 5 (16.7%) of the RApatients were using an anti-tumor necrosis factor alpha therapy (p<0.001). The FMD percentage was significantly smallerin both the PsA and the RA patients than in the healthy controls (p<0.001). The median CIMT was greater in the RA patients compared with the PsA patients and the healthy controls(p=0.008). There was no significant difference in FMD or CIMTbetween patients with and without an active joint lesion.Conclusion: Endothelial functions were impaired in PsA, as inRA, in the absence of conventional risk factors or overt CVD.This finding may show a potential association between PsA,atherosclerosis, and CVD.
AU  - KALYONCU, Umut
AU  - Oral, Hakan
AU  - ERTENLİ, İhsan
AU  - ERDEN, Abdülsamet
AU  - AKDOĞAN, Ali
AU  - Apras Bilgen, Sule
AU  - KİRAZ, Sedat
AU  - CANPOLAT, Uğur
AU  - AYTEMIR, KUDRET
AU  - KARADAĞ, ÖMER
DO  - 10.5543/tkda.2018.36169
PY  - 2018
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 46
IS  - 5
SN  - 1016-5169
SP  - 358
EP  - 365
DB  - TRDizin
UR  - http://search/yayin/detay/353007
ER  -