Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency

KARACA, Neslihan; Kutukculer, Necil; AKSU, Güzide; Eren Akarcan, Sanem; Azarsiz, Elif

doi:10.24953/turkjped.2019.06.010

Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency

Neslihan Karaca, (Ege Üniversitesi, Tıp Fakültesi, İzmir, Türkiye)

Elif Azarsız, (Ege Üniversitesi, Tıp Fakültesi, İzmir, Türkiye)

Sanem Eren Akarcan, (Ege Üniversitesi, Tıp Fakültesi, İzmir, Türkiye)

Güzide Aksu, (Ege Üniversitesi, Tıp Fakültesi, İzmir, Türkiye)

Necil Kütükçüler (Ege Üniversitesi, Tıp Fakültesi, İzmir, Türkiye)

Turkish Journal of Pediatrics

1 0

Yıl: 2019 Cilt: 61 Sayı: 6 Sayfa Aralığı: 885 - 894 Metin Dili: İngilizce DOI: 10.24953/turkjped.2019.06.010 İndeks Tarihi: 18-08-2020

Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency

Öz:

Thymic maturation evaluation is inevitable for patients with clinicaland laboratory findings for a primary immunodeficiency, as the T cellimmunodeficiencies are the most severe type. In this study, we aimed to showthe usage of T cell surface molecule “CD31” for the evaluation of thymicoutput in patients (n: 66) with a large spectrum of findings signing a probableprimary immunodeficiency. Besides the classical clinical and laboratoryapproach for these patients, T cell subpopulations as naive, memory, recentthymic emigrant cells were also investigated. The humoral immunodeficiency(34.8%), combined immunodeficiency (34.8%) and cardiopathy (7.6%) werethe most frequent diagnosis groups. CD4+CD45RA+ naive T-cells percentages(p: 0.011) and absolute counts (p: 0.004) and absolute CD4+CD45RA+CD31+RTE (recent thymic emigrant) cell counts (p: 0.007) were significantly lowerin combined immunodeficiency group. Naive T-cells (p: 0.037) and RTE cells(p: 0.032) were also lower in patients who had cardiac surgery in the past.In conclusion, flow cytometric CD31+thymic naive RTE cell evaluation mayprovide rapid clinical information especially on T-cell immune dysfunctionand CD4+CD45RA+CD31+ RTE cells may be used as an alternative to TRECsin the diagnosis of combined immunodeficiencies.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARACA N, Azarsiz E, Eren Akarcan S, AKSU G, Kutukculer N (2019). Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. , 885 - 894. 10.24953/turkjped.2019.06.010
Chicago	KARACA Neslihan,Azarsiz Elif,Eren Akarcan Sanem,AKSU Güzide,Kutukculer Necil Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. (2019): 885 - 894. 10.24953/turkjped.2019.06.010
MLA	KARACA Neslihan,Azarsiz Elif,Eren Akarcan Sanem,AKSU Güzide,Kutukculer Necil Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. , 2019, ss.885 - 894. 10.24953/turkjped.2019.06.010
AMA	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. . 2019; 885 - 894. 10.24953/turkjped.2019.06.010
Vancouver	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. . 2019; 885 - 894. 10.24953/turkjped.2019.06.010
IEEE	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N "Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency." , ss.885 - 894, 2019. 10.24953/turkjped.2019.06.010
ISNAD	KARACA, Neslihan vd. "Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency". (2019), 885-894. https://doi.org/10.24953/turkjped.2019.06.010

APA	KARACA N, Azarsiz E, Eren Akarcan S, AKSU G, Kutukculer N (2019). Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. Turkish Journal of Pediatrics, 61(6), 885 - 894. 10.24953/turkjped.2019.06.010
Chicago	KARACA Neslihan,Azarsiz Elif,Eren Akarcan Sanem,AKSU Güzide,Kutukculer Necil Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. Turkish Journal of Pediatrics 61, no.6 (2019): 885 - 894. 10.24953/turkjped.2019.06.010
MLA	KARACA Neslihan,Azarsiz Elif,Eren Akarcan Sanem,AKSU Güzide,Kutukculer Necil Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. Turkish Journal of Pediatrics, vol.61, no.6, 2019, ss.885 - 894. 10.24953/turkjped.2019.06.010
AMA	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. Turkish Journal of Pediatrics. 2019; 61(6): 885 - 894. 10.24953/turkjped.2019.06.010
Vancouver	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency. Turkish Journal of Pediatrics. 2019; 61(6): 885 - 894. 10.24953/turkjped.2019.06.010
IEEE	KARACA N,Azarsiz E,Eren Akarcan S,AKSU G,Kutukculer N "Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency." Turkish Journal of Pediatrics, 61, ss.885 - 894, 2019. 10.24953/turkjped.2019.06.010
ISNAD	KARACA, Neslihan vd. "Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency". Turkish Journal of Pediatrics 61/6 (2019), 885-894. https://doi.org/10.24953/turkjped.2019.06.010