Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival
Yıl: 2019 Cilt: 36 Sayı: 1 Sayfa Aralığı: 19 - 24 Metin Dili: İngilizce DOI: 10.4274/tjh.galenos.2018.2018.0015 İndeks Tarihi: 19-08-2020
Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival
Öz: Objective: Hematopoietic stem cell transplantation (HSCT) is a choiceof treatment for malignant and non-malignant diseases. After HSCT,some complications may develop in patients. Cardiac complicationsare particularly important. The aim of this study was to investigatewhether systolic pulmonary artery pressure (PAP) is a marker foroverall survival (OS) in HSCT patients.Materials and Methods: In our study, 428 HSCT patients wereevaluated. Ejection fraction (EF) and PAP values were investigatedduring symptom-oriented echocardiography in the pre-HSCT andpost-HSCT periods.Results: Pre-HSCT EF values were similar between the groups. Inpatients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it wasfound that the 5-year mortality rate was 48.6%, while in the othergroup (PAP <25 mmHg) the 5-year mortality was 25.5%. There wasa significant association between 5-year mortality rate and PAP level(p<0.046) in the auto-HSCT group. OS was 38% in the pre-autoHSCT period with PAP values of >25 mmHg, while OS was 61% inthe pre-auto-HSCT period with PAP values of <25 mmHg (p<0.001).We determined that there was a statistically significant differencebetween OS and PAP levels in patients with auto-HSCT. Five-yearmortality rate and OS were not significantly different in patientsundergoing allogeneic HSCT (allo-HSCT) (p>0.05).Conclusion: Our results suggest that pre-HSCT PAP value is animportant risk factor for mortality and OS in patients undergoingauto-HSCT.
Anahtar Kelime: Kemik İliği Nakli Yapılan Hastalarda Kardiyak Parametrelerin Değerlendirilmesi: Pulmoner Arter Basıncının Sağkalıma Etkisi
Öz: Amaç: Hematopoietik kök hücre transplantasyonu (HKHT) malign ve non-malign hastalıklarda kullanılan bir tedavi seçeneğidir. Nakil sonrasında bir çok komplikasyon gelişmektedir. Kardiyak komplikasyonlar önemli bir yer tutmaktadır. Bu çalışmanın amacı, sistolik pulmoner arter basıncının (PAB) nakil yapılan hastaların sağkalımına olan etkisini araştırmaktır. Gereç ve Yöntemler: Çalışmamızda 428 HKHT yapılan hasta değerlendirildi. Ejeksiyon fraksiyonu (EF) ve PAB değerleri, semptom oryante ekokardiyografi ile post ve pretransplantasyon dönemde değerlendirildi. Bulgular: Karşılaştırılan gruplar arasında pre-HKHT döneminde EF değerleri açısından farklılık saptanmadı. Beş yıllık mortalite otolog HKHT yapılan hastalarda PAB değeri 25 mmHg üzeri olanlarda %48,6, diğer grupta %25,5 olarak gözlendi ve istatistiksel olarak p<0,046 olarak hesaplandı. Total sağkalıma bakıldığında otolog HKHT yapılan hastalarda; nakil öncesi PAB değeri 25 mmHg üzeri olanlarda %38 iken; nakil öncesi PAB değeri 25 mmHg altında olan grupta sağkalım %61 olarak saptandı ve bu durum istatistiksel olarak anlamlı hesaplandı (p<0,001). Aynı verileri değerlendirerek total sağkalım ve PAB değeri arasında otology HKHT yapılan hastalarda anlamlı ilişki oldugunu, allojenik HKHT yapılanlar arasında istatistiksel olarak anlamlı ilişki olmadığını tespit etmiş bulunmaktayız. Sonuç: Çalışmamızın sonuçlarına göre HKHT öncesi ve sonrası ölçülen PAB değeri hastalarda total sağkalım ve mortalite üzerine önemli etkisi olan bir faktör olarak karşımıza çıkmaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | OZDOVER A, GUNDES I, KIRIK M, Haydaroglu Sahin H, Sucu M, PEHLİVAN M (2019). Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. , 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| Chicago | OZDOVER ALİ CANER,GUNDES ILKNUR,KIRIK Melya Pelin,Haydaroglu Sahin Handan,Sucu Murat,PEHLİVAN MUSTAFA Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. (2019): 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| MLA | OZDOVER ALİ CANER,GUNDES ILKNUR,KIRIK Melya Pelin,Haydaroglu Sahin Handan,Sucu Murat,PEHLİVAN MUSTAFA Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. , 2019, ss.19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| AMA | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. . 2019; 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| Vancouver | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. . 2019; 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| IEEE | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M "Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival." , ss.19 - 24, 2019. 10.4274/tjh.galenos.2018.2018.0015 |
| ISNAD | OZDOVER, ALİ CANER vd. "Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival". (2019), 19-24. https://doi.org/10.4274/tjh.galenos.2018.2018.0015 |
| APA | OZDOVER A, GUNDES I, KIRIK M, Haydaroglu Sahin H, Sucu M, PEHLİVAN M (2019). Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology, 36(1), 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| Chicago | OZDOVER ALİ CANER,GUNDES ILKNUR,KIRIK Melya Pelin,Haydaroglu Sahin Handan,Sucu Murat,PEHLİVAN MUSTAFA Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology 36, no.1 (2019): 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| MLA | OZDOVER ALİ CANER,GUNDES ILKNUR,KIRIK Melya Pelin,Haydaroglu Sahin Handan,Sucu Murat,PEHLİVAN MUSTAFA Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology, vol.36, no.1, 2019, ss.19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| AMA | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology. 2019; 36(1): 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| Vancouver | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology. 2019; 36(1): 19 - 24. 10.4274/tjh.galenos.2018.2018.0015 |
| IEEE | OZDOVER A,GUNDES I,KIRIK M,Haydaroglu Sahin H,Sucu M,PEHLİVAN M "Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival." Turkish Journal of Hematology, 36, ss.19 - 24, 2019. 10.4274/tjh.galenos.2018.2018.0015 |
| ISNAD | OZDOVER, ALİ CANER vd. "Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival". Turkish Journal of Hematology 36/1 (2019), 19-24. https://doi.org/10.4274/tjh.galenos.2018.2018.0015 |
