TY  - JOUR
TI  - Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival
AB  - Objective: Hematopoietic stem cell transplantation (HSCT) is a choiceof treatment for malignant and non-malignant diseases. After HSCT,some complications may develop in patients. Cardiac complicationsare particularly important. The aim of this study was to investigatewhether systolic pulmonary artery pressure (PAP) is a marker foroverall survival (OS) in HSCT patients.Materials and Methods: In our study, 428 HSCT patients wereevaluated. Ejection fraction (EF) and PAP values were investigatedduring symptom-oriented echocardiography in the pre-HSCT andpost-HSCT periods.Results: Pre-HSCT EF values were similar between the groups. Inpatients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it wasfound that the 5-year mortality rate was 48.6%, while in the othergroup (PAP <25 mmHg) the 5-year mortality was 25.5%. There wasa significant association between 5-year mortality rate and PAP level(p<0.046) in the auto-HSCT group. OS was 38% in the pre-autoHSCT period with PAP values of >25 mmHg, while OS was 61% inthe pre-auto-HSCT period with PAP values of <25 mmHg (p<0.001).We determined that there was a statistically significant differencebetween OS and PAP levels in patients with auto-HSCT. Five-yearmortality rate and OS were not significantly different in patientsundergoing allogeneic HSCT (allo-HSCT) (p>0.05).Conclusion: Our results suggest that pre-HSCT PAP value is animportant risk factor for mortality and OS in patients undergoingauto-HSCT.
AU  - PEHLİVAN, MUSTAFA
AU  - OZDOVER, ALİ CANER
AU  - GUNDES, ILKNUR
AU  - Haydaroglu Sahin, Handan
AU  - KIRIK, Melya Pelin
AU  - Sucu, Murat
DO  - 10.4274/tjh.galenos.2018.2018.0015
PY  - 2019
JO  - Turkish Journal of Hematology
VL  - 36
IS  - 1
SN  - 1300-7777
SP  - 19
EP  - 24
DB  - TRDizin
UR  - http://search/yayin/detay/353551
ER  -