TY  - JOUR
TI  - The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma
AB  - Objective: Angiotensin II promotes growth and angiogenesis viatype 1 receptors (AGTR1) in certain tumors. In this study, we examinethe bone marrow AGTR1 expression in multiple myeloma (MM) andits relationship with the regulation of angiogenesis and prognosticfactors.Materials and Methods: Bone marrow AGTR1 mRNA levels of 39 MMpatients and 15 healthy controls were analyzed with quantitative RTPCR. Immunohistochemical staining of the tissue vascular endothelialgrowth factor (VEGF), CD34, and factor VIIIrAg (fVIIIrAg) was used toassess bone marrow angiogenesis.Results: Bone marrow samples of the patients showed increasedVEGF, fVIIIrAg, and CD34 staining and higher AGTR1 expression levelswhen compared to controls. Patients with severe-diffuse bone marrowinfiltration showed higher bone marrow VEGF, fVIIIrAg, CD34, andAGTR1 mRNA levels when compared to other patients.Conclusion: AGTR1 expression was found positively correlated withplasma β2-microglobulin level and patients with increased AGTR1expression showed increased bone marrow CD34 levels.
AU  - Aydın Sayitoglu, Muge
AU  - Genc, Sema
AU  - İstemihan, Zülal
AU  - Saka, Bulent
AU  - erten, sebile nilgün
AU  - Tascioglu, Cemil
AU  - KARAN, MEHMET
AU  - DOĞAN, Öner
AU  - Erdem, Simge
AU  - ÖZBEK, Uğur
DO  - 10.4274/tjh.galenos.2019.2018.0420
PY  - 2019
JO  - Turkish Journal of Hematology
VL  - 36
IS  - 3
SN  - 1300-7777
SP  - 178
EP  - 185
DB  - TRDizin
UR  - http://search/yayin/detay/353725
ER  -