TY  - JOUR
TI  - The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study
AB  - Background/aim: Adipokines play an important role in the regulation of metabolism. In critical illness, they alter serum levels and aresuspected to worsen clinical outcomes. But the effect of the route of nutrition on adipokines is not known. The purpose of this studywas to evaluate the association between the route of nutrition and adipokine levels in critically ill patients.Materials and methods: This prospective study was performed in an intensive care unit (ICU). Patients admitted to the ICU for least72 h and receiving either enteral nutrition (EN) via tube feeding or parenteral nutrition (PN) were enrolled. Serum was obtained atbaseline, 24 h, and 72 h for concentrations of leptin, adiponectin, resistin, glucagon–like peptide 1 (GLP–1), insulin–like growth factors1 (IGF–1), and ghrelin.Results: A total of 26 patients were included in the study. Thirteen patients received EN and 13 patients received PN. In the PN group,leptin level significantly increased (P = 0.037), adiponectin and ghrelin significantly decreased during follow up (P = 0.037, P = 0.008,respectively). There was no significant change between all adipokines in the EN group and resistin, IGF–1 and GLP–1 in the PN groupduring follow up. Resistin levels were markedly lower in the EN group at both 24 h (P = 0.015) and 72 h (P = 0.006) while GLP–1 levelswere higher in the EN group at baseline, 24 h, and 72 h (P = 0.018, P = 0.005, and P = 0.003, respectively). There were no differences inleptin, adiponectin, IGF–1, and ghrelin levels over time.Conclusion: The delivery of EN in critical illness was associated with decreased resistin levels and increased GLP–1 levels. Thus, theroute of nutrition may impact the clinical outcome in critical illness due to adipokines.
AU  - GÜNEŞ ŞAHİN, GÜLŞAH
AU  - Şahin Ergül, Serap
AU  - MUHTAROĞLU, Sebahattin
AU  - Gündoğan, Kürşat
AU  - Sungur, Murat
AU  - dogan, ender
AU  - Ziegler, Thomas
AU  - Akbudak, İsmail hakkı
AU  - OZER, NURHAYAT TUGRA
AU  - Güven, Muhammet
DO  - 10.3906/sag-1911-165
PY  - 2020
JO  - Turkish Journal of Medical Sciences
VL  - 50
IS  - 4
SN  - 1300-0144
SP  - 877
EP  - 884
DB  - TRDizin
UR  - http://search/yayin/detay/354669
ER  -