Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri

Aydin Dilsiz, Sevtap; BAŞARAN, NURŞEN; GÜZELSOY KARA, PELİN

doi:10.5336/pharmsci.2018-59816

Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri

Pelin GÜZELSOY, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Sevtap AYDIN, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Nurşen BAŞARAN (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Literatür Eczacılık Bilimleri Dergisi

160 19

Yıl: 2018 Cilt: 7 Sayı: 2 Sayfa Aralığı: 118 - 135 Metin Dili: Türkçe DOI: 10.5336/pharmsci.2018-59816 İndeks Tarihi: 08-09-2020

Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri

Öz:

Bitki antioksidanları, en az yan etkileri ve besin takviyesi olarak önemli rolleri nedeni ile sonzamanlarda popülarite kazanmıştır. Timokinon, Nigella sativa L. (çörek otu) tohumunun uçucu yağından elde edilen ana aktif fenolik bir bileşik olup yüksek antioksidan özellikleri nedeni ile birçok hastalıkta geleneksel olarak yaygın kullanılmaktadır. İn vitro ve in vivo çalışmalarda,timokinonun antiinflamatuar, antimikrobiyal ve antikanser gibi birçok faydalı etkilere sahip olabildiği ileri sürülmektedir. Timokinon toksisitesi üzerine yapılan çalışmalarda, toksik etkileri ancakçok yüksek dozlarında gösterilebilmiştir. Timokinon, yüksek biyolojik etkinliği ve düşük sistemiktoksisitesi ile dikkate değer bilimsel ilgi çekmektedir; bu durum, klasik terapötik ilaçlara umut verici bir alternatif olabilmektedir. Timokinon büyük olasılıkla birçok moleküler hedefleri değiştirmektedir, ancak timokinonun etkileri altında yatan bu moleküler mekanizmalar tam olarakanlaşılmamıştır. Bu geniş etkilerine rağmen timokinonun çeşitli metabolik yolaklar üzerindeki etkilerinin daha iyi anlaşılabilmesi açısından daha ileri çalışmalara gereksinim olduğu görülmektedir.Bu çalışmada, Nigella sativa L. tohumlarının aktif maddesi olan timokinonun farmakolojik ve toksikolojik özelliklerinin kapsamlı olarak değerlendirilmesi amaçlanmıştır. Bulgular, timokinonunklinik araştırmalarda yeni bir ilaç olarak geliştirilmesi gerektiğini göstermektedir.

Anahtar Kelime:

Potential Effects of Thymoquinone the Active Constituent of Black Seed (Nigella Sativa L.) on Human Health

Öz:

Plant antioxidants have recently gained popularity due to their important role as dietary supplements with minimal side effects. Thymoquinone, the main active phenolic compound from the volatile oil of Nigella sativa L. seeds has been commonly used traditionally for several diseases due its high antioxidant properties. In in vitro and in vivo studies, thymoquinone has suggested to have many beneficial effects such as antiinflamatory, antimicrobial, and anticancer effects. In the studies on thymoquinone toxicity, its toxic effects could only be demonstrated at very high doses. Thymoquinone has attracted noteworthy scientific attention for its high biological activity and low systemic toxicity, which might be a promising alternative to conventional therapeutic drugs. It is likely that thymoquinone modifies a number of molecular targets; however, the molecular mechanisms underlying the effects of thymoquinone remain not fully understood. Despite these wide effects, it seems that the further study is needed to better understand the effects of thymoquinone on various metabolic pathways. In this review, the pharmacological and toxicological property of thymoquinone, which is the active ingredient of Nigella sativa L. seeds is evaluated. The evidence shows that thymoquinone should be developed as a novel drug in clinical trials.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	GÜZELSOY KARA P, Aydin Dilsiz S, BAŞARAN N (2018). Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. , 118 - 135. 10.5336/pharmsci.2018-59816
Chicago	GÜZELSOY KARA PELİN,Aydin Dilsiz Sevtap,BAŞARAN NURŞEN Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. (2018): 118 - 135. 10.5336/pharmsci.2018-59816
MLA	GÜZELSOY KARA PELİN,Aydin Dilsiz Sevtap,BAŞARAN NURŞEN Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. , 2018, ss.118 - 135. 10.5336/pharmsci.2018-59816
AMA	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. . 2018; 118 - 135. 10.5336/pharmsci.2018-59816
Vancouver	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. . 2018; 118 - 135. 10.5336/pharmsci.2018-59816
IEEE	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N "Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri." , ss.118 - 135, 2018. 10.5336/pharmsci.2018-59816
ISNAD	GÜZELSOY KARA, PELİN vd. "Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri". (2018), 118-135. https://doi.org/10.5336/pharmsci.2018-59816

APA	GÜZELSOY KARA P, Aydin Dilsiz S, BAŞARAN N (2018). Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. Literatür Eczacılık Bilimleri Dergisi, 7(2), 118 - 135. 10.5336/pharmsci.2018-59816
Chicago	GÜZELSOY KARA PELİN,Aydin Dilsiz Sevtap,BAŞARAN NURŞEN Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. Literatür Eczacılık Bilimleri Dergisi 7, no.2 (2018): 118 - 135. 10.5336/pharmsci.2018-59816
MLA	GÜZELSOY KARA PELİN,Aydin Dilsiz Sevtap,BAŞARAN NURŞEN Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. Literatür Eczacılık Bilimleri Dergisi, vol.7, no.2, 2018, ss.118 - 135. 10.5336/pharmsci.2018-59816
AMA	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. Literatür Eczacılık Bilimleri Dergisi. 2018; 7(2): 118 - 135. 10.5336/pharmsci.2018-59816
Vancouver	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri. Literatür Eczacılık Bilimleri Dergisi. 2018; 7(2): 118 - 135. 10.5336/pharmsci.2018-59816
IEEE	GÜZELSOY KARA P,Aydin Dilsiz S,BAŞARAN N "Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri." Literatür Eczacılık Bilimleri Dergisi, 7, ss.118 - 135, 2018. 10.5336/pharmsci.2018-59816
ISNAD	GÜZELSOY KARA, PELİN vd. "Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri". Literatür Eczacılık Bilimleri Dergisi 7/2 (2018), 118-135. https://doi.org/10.5336/pharmsci.2018-59816