Yıl: 2019 Cilt: 4 Sayı: 1 Sayfa Aralığı: 38 - 42 Metin Dili: İngilizce

Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?

Öz:
BACKGROUND/AIMSTo evaluate the variations in platelet indices (PIs), including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), in cervical cancer (CC) and to evaluate the relationship between these PIs and pathological features of tumor (i.e., tumor stage and size, depth of stromal invasion, lymphovascular space invasion (LVSI), and histological type).MATERIAL and METHODSThis retrospective, comparative study included 40 patients with CC who underwent complete clinical staging and 80 healthy controls at a tertiary center between 2007 and 2017. Groups were compared using independent sample t-tests and Mann–Whitney U tests. Variables with a p<0.05 were included in the receiver operating characteristic curve analysis to determine cut-off values. The associations of PIs with pathological features were analyzed using the chi-square test.RESULTSThe mean age of patients with CC was 56.9 years old. Demographic characteristics (i.e., age, gravidity, and parity) did not differ between the groups (p>0.05). Mean MPV and PCT were significantly lower (p=0.002 and p=0.026, respectively), and PDW was significantly higher (p=0.049) in the CC group than in the control group. The platelet count did not differ significantly between the groups (p=0.558). The optimal cut-off points of MPV, PDW, and PCT levels for discriminating between the groups were 10.45 fL, 13 fL, and 0.28%, respectively. Except a significant relationship between low PCT level and positive LVSI (p=0.01), there was no significant relationship between PIs and pathological features.CONCLUSIONLow MPV and PDW and high PCT may be considered as a useful additional tool for preoperative diagnosis of CC. However, the usability of these markers for predicting pathological features is unsatisfactory.
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Konular:
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA TAŞ E, AKÇAY G, KESKİN H, KIR E, YAVUZ A (2019). Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus Journal of Medical Sciences, 4(1), 38 - 42.
Chicago TAŞ EMRE ERDEM,AKÇAY Gulin,KESKİN HÜSEYİN LEVENT,KIR Edip,YAVUZ Ayşe filiz Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus Journal of Medical Sciences 4, no.1 (2019): 38 - 42.
MLA TAŞ EMRE ERDEM,AKÇAY Gulin,KESKİN HÜSEYİN LEVENT,KIR Edip,YAVUZ Ayşe filiz Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus Journal of Medical Sciences, vol.4, no.1, 2019, ss.38 - 42.
AMA TAŞ E,AKÇAY G,KESKİN H,KIR E,YAVUZ A Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus Journal of Medical Sciences. 2019; 4(1): 38 - 42.
Vancouver TAŞ E,AKÇAY G,KESKİN H,KIR E,YAVUZ A Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus Journal of Medical Sciences. 2019; 4(1): 38 - 42.
IEEE TAŞ E,AKÇAY G,KESKİN H,KIR E,YAVUZ A "Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?." Cyprus Journal of Medical Sciences, 4, ss.38 - 42, 2019.