Yıl: 2020 Cilt: 3 Sayı: 1 Sayfa Aralığı: 40 - 44 Metin Dili: İngilizce DOI: 10.5505/anatoljfm.2019.35220 İndeks Tarihi: 10-09-2020

Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia

Öz:
Objectives: Parvovirus B19 belonging to the Erythrovirus genus is a single-stranded DNA virus in the familyParvoviridae. The present study aims to determine parvovirus B19 seropositivity in serum samples sent withpre-diagnosis of arthritis/arthralgia and to evaluate the age dispersion retrospectively.Methods: Sixty-one patients with pre-diagnosis of arthritis/arthralgia were included in this study. The patients’age ranged from 8 to 85 years old. In serum samples of the patients, parvovirus B19 IgM and IgG tests wereinvestigated using the enzyme immunoassay method.Results: The mean age of the patients was 45.2±17.8 years. Parvovirus B19 IgG and IgM positivity rates were40 (65.6%) and 2 (3.3%), respectively. Parvovirus B19 IgG positivity was highest at the ages over 50 years andlowest at the ages under 30 years (p=0.362). Parvovirus B19 IgG seropositivity was the highest in females witha rate of 72.0% (p=0.241).Conclusion: As a result, parvovirus B19 IgG and IgM positivity rates in the patient group with pre-diagnosis ofarthritis/arthralgia were 65.6% and 3.3%, respectively, in our study. As the parvovirus B19 seropositivity ratewas found high when compared to the general population studies, latent parvovirus B19 infection should beinvestigated in synovial tissue in patients with chronical arthritis and arthralgia complaints.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Young NS, Brown KE. Parvovirus B19. N Engl J Med 2004;350(6):586–97.
  • 2. Corcoran A, Doyle S. Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19. J Med Microbiol 2004;53(Pt 6):459–75.
  • 3. Tolfvenstam T, Broliden K. Parvovirus B19 infection. Semin Fetal Neonatal Med 2009;14(4):218–21.
  • 4. Broliden K. Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation. Pediatr Transplant 2001;5(5):320–30.
  • 5. Anderson LJ, Tsou C, Parker RA, Chorba TL, Wulff H, Tattersall P, et al. Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. J Clin Microbiol 1986;24(4):522–6.
  • 6. Colmegna I, Alberts-Grill N. Parvovirus B19: its role in chronic arthritis. Rheum Dis Clin North Am 2009;35(1):95–110.
  • 7. Anderson M, Cohen B, Schwarz T, Roggendorf M, Deinhardt F. Human parvovirus B19 infections in United Kingdom 1984- 86. Lancet 1987;1(8535):738–9.
  • 8. Gilbert NL, Gyorkos TW, Béliveau C, Rahme E, Muecke C, Soto JC. Seroprevalence of parvovirus B19 infection in daycare educators. Epidemiol Infect 2005;133(2):299–304.
  • 9. Kerr JR. A review of blood diseases and cytopenias associated with human parvovirus B19 infection. Rev Med Virol 2015;25(4):224–40.
  • 10. Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev 2002;15(3):485–505.
  • 11. Kerr JR. Pathogenesis of human parvovirus B19 in rheumatic disease. Ann Rheum Dis 2000;59(9):672–83.
  • 12. Vassilopoulos D, Calabrese LH. Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations. Arthritis Res Ther 2008;10(5):215.
  • 13. Beigi RH, Wiesenfeld HC, Landers DV, Simhan HN. High rate of severe fetal outcomes associated with maternal parvovirus b19 infection in pregnancy. Infect Dis Obstet Gynecol 2008;2008:524601.
  • 14. Jensen IP, Thorsen P, Jeune B, Møller BR, Vestergaard BF. An epidemic of parvovirus B19 in a population of 3,596 pregnant women: a study of sociodemographic and medical risk factors. BJOG 2000;107(5):637–43.
  • 15. Caliskan R, Masatlioglu S, Aslan M, Altun S, Saribas S, Ergin S, et al. The relationship between arthritis and human parvovirus B19 infection. Rheumatol Int 2005;26(1):7–11.
  • 16. Moore TL. Parvovirus-associated arthritis. Curr Opin Rheumatol 2000;12(4):289–94.
  • 17. Ogawa E, Otaguro S, Murata M, Kainuma M, Sawayama Y, Furusyo N, et al. Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection. J Infect Chemother 2008;14(5):377–82.
  • 18. Stahl HD, Seidl B, Hubner B, Altrichter S, Pfeiffer R, Pustowoit B, et al. High incidence of parvovirus B19 DNA in synovial tissue of patients with undifferentiated mono- and oligoarthritis. Clin Rheumatol 2000;19(4):281–6.
  • 19. Nocton JJ, Miller LC, Tucker LB, Schaller JG. Human parvovirus B19-associated arthritis in children. J Pediatr 1993;122(2):186– 90.
  • 20. Hokynar K, Brunstein J, Söderlund-Venermo M, Kiviluoto O, Partio EK, Konttinen Y, et al. Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue. J Gen Virol 2000;81(Pt 4):1017–25.
  • 21. Meyer O. Parvovirus B19 and autoimmune diseases. Joint Bone Spine 2003;70(1):6–11.
  • 22. Türk Dağı H. Parvovirus B19. Genel Tıp Derg 2013;23(3):96– 102.
  • 23. Blümel J, Burger R, Drosten C, Gröner A, Gürtler L, Heiden M, et al. Parvovirus B19 - Revised. Transfus Med Hemother 2010;37(6):339–50.
  • 24. Zadsar M, Aghakhani A, Banifazl M, Kazemimanesh M, Tabatabaei Yazdi SM, Mamishi S, et al. Seroprevalence, molecular epidemiology and quantitation of parvovirus B19 DNA levels in Iranian blood donors. J Med Virol 2018;90(8):1318–22.
  • 25. Mossong J, Hens N, Friederichs V, Davidkin I, Broman M, Litwinska B, et al. Parvovirus B19 infection in five European countries: seroepidemiology, force of infection and maternal risk of infection. Epidemiol Infect 2008;136(8):1059–68.
  • 26. Buyukkose M, Kozanoglu E, Basaran S, Bayramoglu O, Yarkin F. Seroprevalence of parvovirus B19 in fibromyalgia syndrome. Clin Rheumatol 2009;28(3):305–9.
  • 27. Türk Dağı H, Ozdemir M, Baykan M, Baysal B. Investigation of parvovirus B19 seroprevalence in various age groups in Central Anatolia Region, Turkey. Mikrobiyol Bul 2010;44(3):467– 72.
  • 28. Aktaş O, Aydin H, Uslu H. Serological prevalence of human parvovirus B19 in diseases or disordersrelated to different human body systems. Turk J Med Sci 2016;46(2):368–73.
  • 29. Göral Ş, Yenicesu İ, Bozdayı G, Duyan Çamurdan A, Altay Koçak A. Parvovirus B19 seroprevalence in Turkish blood donors. Turk J Med Sci 2018;48(5):956–60.
  • 30. Röhrer C, Gärtner B, Sauerbrei A, Böhm S, Hottenträger B, Raab U, et al. Seroprevalence of parvovirus B19 in the German population. Epidemiol Infect 2008;136(11):1564–75.
  • 31. Kishore J, Srivastava M, Choudhary N. Standardization of B19 IgG ELISA to study the seroepidemiology of parvovirus B19 in North Indian voluntary blood donors. Asian J Transfus Sci 2010;4(2):86–90.
  • 32. Ghazi HO. Prevalence of antibodies to human parvovirus b19 in saudi women of childbearing age in makkah. J Family Community Med 2007;14(1):15–7.
  • 33. Kumar S, Gupta RM, Sen S, Sarkar RS, Philip J, Kotwal A, et al. Seroprevalence of human parvovirus B19 in healthy blood donors. Med J Armed Forces India 2013;69(3):268–72.
APA TÜRKMEN ALBAYRAK H, Bakir A, GÜNEY M, YAVUZ M (2020). Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. , 40 - 44. 10.5505/anatoljfm.2019.35220
Chicago TÜRKMEN ALBAYRAK HİLAL,Bakir Ayfer,GÜNEY MUSTAFA,YAVUZ MEHMET TEVFIK Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. (2020): 40 - 44. 10.5505/anatoljfm.2019.35220
MLA TÜRKMEN ALBAYRAK HİLAL,Bakir Ayfer,GÜNEY MUSTAFA,YAVUZ MEHMET TEVFIK Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. , 2020, ss.40 - 44. 10.5505/anatoljfm.2019.35220
AMA TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. . 2020; 40 - 44. 10.5505/anatoljfm.2019.35220
Vancouver TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. . 2020; 40 - 44. 10.5505/anatoljfm.2019.35220
IEEE TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M "Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia." , ss.40 - 44, 2020. 10.5505/anatoljfm.2019.35220
ISNAD TÜRKMEN ALBAYRAK, HİLAL vd. "Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia". (2020), 40-44. https://doi.org/10.5505/anatoljfm.2019.35220
APA TÜRKMEN ALBAYRAK H, Bakir A, GÜNEY M, YAVUZ M (2020). Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. The anatolian journal of family medicine (Online) , 3(1), 40 - 44. 10.5505/anatoljfm.2019.35220
Chicago TÜRKMEN ALBAYRAK HİLAL,Bakir Ayfer,GÜNEY MUSTAFA,YAVUZ MEHMET TEVFIK Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. The anatolian journal of family medicine (Online) 3, no.1 (2020): 40 - 44. 10.5505/anatoljfm.2019.35220
MLA TÜRKMEN ALBAYRAK HİLAL,Bakir Ayfer,GÜNEY MUSTAFA,YAVUZ MEHMET TEVFIK Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. The anatolian journal of family medicine (Online) , vol.3, no.1, 2020, ss.40 - 44. 10.5505/anatoljfm.2019.35220
AMA TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. The anatolian journal of family medicine (Online) . 2020; 3(1): 40 - 44. 10.5505/anatoljfm.2019.35220
Vancouver TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia. The anatolian journal of family medicine (Online) . 2020; 3(1): 40 - 44. 10.5505/anatoljfm.2019.35220
IEEE TÜRKMEN ALBAYRAK H,Bakir A,GÜNEY M,YAVUZ M "Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia." The anatolian journal of family medicine (Online) , 3, ss.40 - 44, 2020. 10.5505/anatoljfm.2019.35220
ISNAD TÜRKMEN ALBAYRAK, HİLAL vd. "Investigation into Parvovirus B19 Antibodies in Serum Samples Sent with Pre-diagnosis of Arthritis-Arthralgia". The anatolian journal of family medicine (Online) 3/1 (2020), 40-44. https://doi.org/10.5505/anatoljfm.2019.35220