TY  - JOUR
TI  - Synthesis, In Vitro Anticholinesterase and Antimicrobial Evaluation of New 1,3,4-Thiadiazole-Piperazine Derivatives
AB  - In this study, 8 new compounds having 2-((5-substituted-1,3,4-thiadazol-2-yl)amino)-2-oxoethyl-4-substituepiperazine-1-carbodithioate structures were synthesized, antimicrobial and anticholinesterase activitieswere evaluated. The structures of synthesized compounds were proved by 1H NMR, 13C NMR and mass spectra.The synthesized compounds were tested for antibacterial activity against eight bacteria strains and antifungalactivity against four fungus strains. When the antibacterial activities of the compounds were examined, it wasfound that the compounds 3c, 3d, 3g and 3h were effective against E. faecalis (ATCC 29212) and E. faecalis(ATCC 51922) with MIC value of 25 μg/mL. It was determined that the carbon chain at the para position ofpiperazine increased the activity but where as the addition of benzyl group to the para position (3a, 3b, 3e, 3f)did not affect the activity. Furthermore, the acetylcholinesterase activity of the synthesized compounds wasexamined but none of the compounds showed AChE inhibitory activity as much as standard drug Donepezil.
AU  - SAGLIK, BEGÜM NURPELIN
AU  - ACAR ÇEVİK, ULVİYE
DO  - 10.35193/bseufbd.601344
PY  - 2019
JO  - Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi
VL  - 6
IS  - 2
SN  - 2458-7575
SP  - 424
EP  - 432
DB  - TRDizin
UR  - http://search/yayin/detay/356991
ER  -