Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Sezgin Bayindir, Zerrin; Ergin, Ahmet Doğan; Yuksel, Nilufer

doi:10.35333/jrp.2019.38

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Ahmet ERGİN, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Zerrin SEZGİN BAYINDIR, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Nilüfer YÜKSEL (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Journal of research in pharmacy (online)

7 0

Yıl: 2019 Cilt: 23 Sayı: 5 Sayfa Aralığı: 914 - 926 Metin Dili: İngilizce DOI: 10.35333/jrp.2019.38 İndeks Tarihi: 16-09-2020

Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles

Öz:

S-adenosyl-L-methionine (SAMe) is an endogenic methyl donor naturally present in all living cells; it hashigh water solubility, but its bioavailability is low in oral administration due to the first pass effect in the liver. The aimof this study is to prepare colon targeted chitosan nanoparticles containing SAMe by ionic gelation. In the preparationof the formulations, the effects of chitosan concentration, tripolyphosphate (TPP) concentration and the amount ofSAMe on the specifications of the nanoparticles such as particle size, zeta potential, encapsulation efficiency, andprocess yield, were investigated. Drug-excipient interactions were evaluated by differential scanning calorimetry (DSC)and Fourier transform infrared (FTIR) spectroscopy. The obtained nanoparticles showed bimodal particle sizedistribution ranging between 228.3-763.9 nm and their zeta potentials were within 14.10-23.30 mV. The drugencapsulation efficiencies and process yields of the nanoparticles were low. However, when the effects of the processparameters on the characteristics of nanoparticles were examined, the chitosan concentration and SAMe amount weresignificant parameters affecting particle size. The chitosan concentration was also found to have a significant effect onprocess yield (p <0.05). Drug release from nanoparticles was evaluated according to different kinetic models and it wasfound that the release mechanism was Fickian diffusion.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ergin A, Sezgin Bayindir Z, Yuksel N (2019). Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. , 914 - 926. 10.35333/jrp.2019.38
Chicago	Ergin Ahmet Doğan,Sezgin Bayindir Zerrin,Yuksel Nilufer Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. (2019): 914 - 926. 10.35333/jrp.2019.38
MLA	Ergin Ahmet Doğan,Sezgin Bayindir Zerrin,Yuksel Nilufer Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. , 2019, ss.914 - 926. 10.35333/jrp.2019.38
AMA	Ergin A,Sezgin Bayindir Z,Yuksel N Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. . 2019; 914 - 926. 10.35333/jrp.2019.38
Vancouver	Ergin A,Sezgin Bayindir Z,Yuksel N Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. . 2019; 914 - 926. 10.35333/jrp.2019.38
IEEE	Ergin A,Sezgin Bayindir Z,Yuksel N "Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles." , ss.914 - 926, 2019. 10.35333/jrp.2019.38
ISNAD	Ergin, Ahmet Doğan vd. "Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles". (2019), 914-926. https://doi.org/10.35333/jrp.2019.38

APA	Ergin A, Sezgin Bayindir Z, Yuksel N (2019). Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of research in pharmacy (online), 23(5), 914 - 926. 10.35333/jrp.2019.38
Chicago	Ergin Ahmet Doğan,Sezgin Bayindir Zerrin,Yuksel Nilufer Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of research in pharmacy (online) 23, no.5 (2019): 914 - 926. 10.35333/jrp.2019.38
MLA	Ergin Ahmet Doğan,Sezgin Bayindir Zerrin,Yuksel Nilufer Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of research in pharmacy (online), vol.23, no.5, 2019, ss.914 - 926. 10.35333/jrp.2019.38
AMA	Ergin A,Sezgin Bayindir Z,Yuksel N Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of research in pharmacy (online). 2019; 23(5): 914 - 926. 10.35333/jrp.2019.38
Vancouver	Ergin A,Sezgin Bayindir Z,Yuksel N Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles. Journal of research in pharmacy (online). 2019; 23(5): 914 - 926. 10.35333/jrp.2019.38
IEEE	Ergin A,Sezgin Bayindir Z,Yuksel N "Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles." Journal of research in pharmacy (online), 23, ss.914 - 926, 2019. 10.35333/jrp.2019.38
ISNAD	Ergin, Ahmet Doğan vd. "Characterization and optimization of colon targeted S-adenosyl-L-methionine loaded chitosan nanoparticles". Journal of research in pharmacy (online) 23/5 (2019), 914-926. https://doi.org/10.35333/jrp.2019.38