Yıl: 2019 Cilt: 30 Sayı: 4 Sayfa Aralığı: 279 - 286 Metin Dili: Türkçe DOI: 10.5080/u23526

Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı

Öz:
Amaç: Alzheimer hastalığı (AH) beyinde yapısal ve işlevsel değişimlermeydana getiren nörodejeneratif bir hastalıktır. Gelişen beyingörüntüleme yöntemleri sayesinde AH patolojisine eşlik eden yapısal veişlevsel bağlantılardaki bozulmalar gitgide daha görünür hale gelmiştir.AH’de dinlenim durumu bağlantısallığında, özellikle de olağandurum ağı (default mode network - DMN) olarak adlandırılan içselbağlantısallık ağında farklılaşmalar görülmektedir. Bu çalışmada DMNbağlantısallık bulgularının incelenmesi ve tartışılması amaçlanmıştır.Yöntem: İşlevsel manyetik rezonans görüntüleme (fMRI) çalışmalarındaen yaygın kullanılan 2 temel metodoloji (tohum temelli ve bağımsızbileşen analizi) temel alınarak alanda yapılan çalışmalar incelenmiştir.Bulgular: Çalışmalar genel olarak, DMN bağlantısallığının AH süreciboyunca ilerleyici bir şekilde bozulduğunu göstermektedir. DMNalt sistemlerinin AH’nin preklinik ve prodromal evrelerinde farklıbağlantısallık örüntüleri gösterdiği de belirtilmektedir. DMN’dekibozulmanın diğer bağlantısallık ağlarındaki farklılaşma ile ilişkiliolabileceğini öne süren kanıtlar da mevcuttur. Buna ek olarak, bulgularDMN’nin AH ile ilişkili nöropatoloji ve genetik risk faktörleri ile olanilişkisine de işaret etmektedir.Sonuç: AH’nin beyinde başta DMN olmak üzere diğer dinlenim durumuağlarında işlevsel bozulmalara yol açan yaygın bir diskonneksiyonsendromu olduğu öne sürülebilir. Buna ek olarak, preklinik vakalarda verisk taşıyan kişilerde de saptanabilen AH ile ilişkili işlevsel bağlantısallıkdeğişimleri AH için muhtemel bir biyo-belirteç olabilir.
Anahtar Kelime:

Default Mode Network Connectivity in Alzheimer’s Disease

Öz:
Objective: Alzheimer’s Disease (AD) is a neurodegenerative condition characterized by functional and structural changes in the brain that are increasingly better visualized with the advances in new brain imaging techniques. Connectivity changes under the resting state condition especially in the internal connectivity network, named as the default mode network (DMN), are observed in AD. This paper aimed to investigate and discuss the findings on DMN connectivity. Method: The studies carried out by functional magnetic resonance imaging (fMRI), using the two most widely applied techniques, the seed-based method and independent component analysis (ICA), have been investigated. Results: Studies generally indicate a progressive impairment in DMN connectivity during the course of AD. It has been also stated that DMN subsystems show differential connectivity patterns in the preclinical and prodromal stages of AD. There is also evidence suggesting that impairment in DMN connectivity could be associated with different connectivity patterns in other networks. Furthermore, findings point towards a relationship between DMN and AD-related neuropathology and genetic risk factors. Conclusion: It may be proposed that AD is a generalized disconnection syndrome that causes functional impairments in resting state networks, particularly in DMN. In addition to this, AD-related functional connectivity changes observed in preclinical cases and risk carriers might be a potential bio-marker for AD.
Anahtar Kelime:

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APA YILDIRIM E, BÜYÜKİŞCAN E (2019). Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. , 279 - 286. 10.5080/u23526
Chicago YILDIRIM Elif,BÜYÜKİŞCAN Ezgi SONCU Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. (2019): 279 - 286. 10.5080/u23526
MLA YILDIRIM Elif,BÜYÜKİŞCAN Ezgi SONCU Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. , 2019, ss.279 - 286. 10.5080/u23526
AMA YILDIRIM E,BÜYÜKİŞCAN E Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. . 2019; 279 - 286. 10.5080/u23526
Vancouver YILDIRIM E,BÜYÜKİŞCAN E Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. . 2019; 279 - 286. 10.5080/u23526
IEEE YILDIRIM E,BÜYÜKİŞCAN E "Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı." , ss.279 - 286, 2019. 10.5080/u23526
ISNAD YILDIRIM, Elif - BÜYÜKİŞCAN, Ezgi SONCU. "Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı". (2019), 279-286. https://doi.org/10.5080/u23526
APA YILDIRIM E, BÜYÜKİŞCAN E (2019). Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. Türk Psikiyatri Dergisi, 30(4), 279 - 286. 10.5080/u23526
Chicago YILDIRIM Elif,BÜYÜKİŞCAN Ezgi SONCU Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. Türk Psikiyatri Dergisi 30, no.4 (2019): 279 - 286. 10.5080/u23526
MLA YILDIRIM Elif,BÜYÜKİŞCAN Ezgi SONCU Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. Türk Psikiyatri Dergisi, vol.30, no.4, 2019, ss.279 - 286. 10.5080/u23526
AMA YILDIRIM E,BÜYÜKİŞCAN E Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. Türk Psikiyatri Dergisi. 2019; 30(4): 279 - 286. 10.5080/u23526
Vancouver YILDIRIM E,BÜYÜKİŞCAN E Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı. Türk Psikiyatri Dergisi. 2019; 30(4): 279 - 286. 10.5080/u23526
IEEE YILDIRIM E,BÜYÜKİŞCAN E "Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı." Türk Psikiyatri Dergisi, 30, ss.279 - 286, 2019. 10.5080/u23526
ISNAD YILDIRIM, Elif - BÜYÜKİŞCAN, Ezgi SONCU. "Alzheimer Hastalığında Olağan Durum Ağı Bağlantısallığı". Türk Psikiyatri Dergisi 30/4 (2019), 279-286. https://doi.org/10.5080/u23526