Tumor suppressor and oncogenic role of long non-coding RNAs in cancer

GÖÇMEN, Melek; KARACAOĞLU, Şeymanur; OKYAY, Tuğba Muhlise; Yalçınkaya, Burhanettin; GÜZEL, Esra; AKÇAKUYU, Muhammed Hüseyin

doi:10.14744/nci.2019.46873

Tumor suppressor and oncogenic role of long non-coding RNAs in cancer

Esra GÜZEL, (Sağlık Bilimleri Üniversitesi, Hamidiye Sağlık Bilimleri Enstitüsü, Moleküler Biyoloji ve Genetik Anabilim Dalı, İstanbul, Türkiye)

Tuğba Muhlise OKYAY, (Sağlık Bilimleri Üniversitesi Hamidiye Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Burhanettin YALÇINKAYA, (TÜBİTAK Ulusal Metroloji Enstitüsü (UME), Kocaeli, Türkiye)

Şeymanur KARACAOĞLU, (Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, İstanbul, Türkiye)

Melek GÖÇMEN, (Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, İstanbul, Türkiye)

Muhammed Hüseyin AKÇAKUYU (Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, İstanbul, Türkiye)

İstanbul Kuzey Klinikleri

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Yıl: 2020 Cilt: 7 Sayı: 1 Sayfa Aralığı: 81 - 86 Metin Dili: İngilizce DOI: 10.14744/nci.2019.46873 İndeks Tarihi: 17-09-2020

Tumor suppressor and oncogenic role of long non-coding RNAs in cancer

Öz:

Non-coding RNAs are RNA molecules that are not translated into the protein, making up the vast majority of the humangenome. Long non-coding RNAs (lncRNA) are in the RNA group that has longer than 200 nucleotides, and non-protein coding transcripts. In recent years, the potential has attracted considerable attention as new important biological regulators.LncRNAs play a critical role in regulating the activity and localization of proteins, processing the production of small RNAs, andprocessing other RNAs. They are also involved in cell differentiation, cell cycle, proliferation, apoptosis, migration and invasion by modulation of gene expression. Abnormal expression of LncRNAs has an important role in the function of oncogenesand tumor suppressor genes. Recently, there has been an increasing number of studies on the tumorigenic effects of specificlncRNAs in the initiation and progression of cancer. In this review, general information about lncRNAs is provided, includingthe biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications.

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1. Li X, Wang Z. The role of noncoding RNA in thyroid cancer. Gland Surg 2012;1:146–50.
2. Su Y, Wu H, Pavlosky A, Zou LL, Deng X, Zhang ZX, et al. Regulatory non-coding RNA: new instruments in the orchestration of cell death. Cell Death Dis 2016;7:e2333.
3. Wei MM, Zhou GB. Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer. Genomics Proteomics Bioinformatics 2016;14:280–8.
4. Ping G, Xiong W, Zhang L, Li Y, Zhang Y, Zhao Y. Silencing long noncoding RNA PVT1 inhibits tumorigenesis and cisplatin resistance of colorectal cancer. Am J Transl Res 2018;10:138–49.
5. Hansji H, Leung EY, Baguley BC, Finlay GJ, Askarian-Amiri ME. Keeping abreast with long non-coding RNAs in mammary gland development and breast cancer. Front Genet 2014;5:379.
6. Harrow J, Frankish A, Gonzalez JM, Tapanari E, Diekhans M, Kokocinski F, et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res 2012;22:1760–74.
7. Misawa A, Takayama KI, Inoue S. Long non-coding RNAs and prostate cancer. Cancer Sci 2017;108:2107–14.
8. Malhotra A, Jain M, Prakash H, Vasquez KM, Jain A. The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer. Oncotarget 2017;8:110671–84.
9. Schmitt AM, Chang HY. Long Noncoding RNAs in Cancer Pathways. Cancer Cell 2016;29:452–63.
10. Huo X, Han S, Wu G, Latchoumanin O, Zhou G, Hebbard L, et al. Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells. Mol Cancer 2017;16:165.
11. Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao SD, et al. Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell 2015;28:529–40.
12. Zack TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G, Tabak B, et al. Pan-cancer patterns of somatic copy number alteration. Nat Genet 2013;45:1134–40.
13. Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci 2016;73:2491–509.
14. Balbin OA, Malik R, Dhanasekaran SM, Prensner JR, Cao X, Wu YM, et al. The landscape of antisense gene expression in human cancers. Genome Res 2015;25:1068–79.
15. Chen J, Sun M, Kent WJ, Huang X, Xie H, Wang W, et al. Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res 2004;32:4812–20.
16. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma. Pharmacol Ther 2016;161:67–78.
17. Shi D, Zhang C, Liu X. Long noncoding RNAs in cervical cancer. J Cancer Res Ther 2018;14:745–53.
18. Di Gesualdo F, Capaccioli S, Lulli M. A pathophysiological view of the long non-coding RNA world. Oncotarget 2014;5:10976–96.
19. Yarmishyn AA, Kurochkin IV. Long noncoding RNAs: a potential novel class of cancer biomarkers. Front Genet 2015;6:145.
20. Hauptman N, Glavač D. Long non-coding RNA in cancer. Int J Mol Sci 2013;14:4655–69.
21. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010;142:409– 19.
22. Geisler S, Lojek L, Khalil AM, Baker KE, Coller J. Decapping of long noncoding RNAs regulates inducible genes. Mol Cell 2012;45:279–91.
23. Meng Q, Ren M, Li Y, Song X. LncRNA-RMRP Acts as an Oncogene in Lung Cancer. PLoS One 2016;11:e0164845.
24. Tanoglu A, Balta AZ, Berber U, Ozdemir Y, Emirzeoglu L, Sayilir A, et al. MicroRNA expression profile in patients with stage II colorectal cancer: a Turkish referral center study. Asian Pac J Cancer Prev 2015;16:1851–5.
25. Shenouda SK, Alahari SK. MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev 2009;28:369–78.
26. Inamura K. Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer. Cells 2017;6. pii: E12.
27. Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov 2011;1:391–407.
28. Liang S, Gong X, Zhang G, Huang G, Lu Y, Li Y. The lncRNA XIST interacts with miR-140/miR-124/iASPP axis to promote pancreatic carcinoma growth. Oncotarget 2017;8:113701–18.
29. Sunamura N, Ohira T, Kataoka M, Inaoka D, Tanabe H, Nakayama Y, et al. Regulation of functional KCNQ1OT1 lncRNA by β-catenin. Sci Rep 2016;6:20690.
30. Yu G, Liu G, Yuan D, Dai J, Cui Y, Tang X. Long non-coding RNA ANRIL is associated with a poor prognosis of osteosarcoma and promotes tumorigenesis via PI3K/Akt pathway. J Bone Oncol 2018;11:51–5.
31. Wu JH, Tang JM, Li J, Li XW. Upregulation of SOX2-activated lncRNA ANRIL promotes nasopharyngeal carcinoma cell growth. Sci Rep 2018;8:3333.
32. Lin Y, Guo W, Li N, Fu F, Lin S, Wang C. Polymorphisms of long non-coding RNA HOTAIR with breast cancer susceptibility and clinical outcomes for a southeast Chinese Han population. Oncotarget 2017;9:3677–89.
33. Pawłowska E, Szczepanska J, Blasiak J. The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role? Int J Mol Sci 2017;18. pii: E2317.
34. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to pro- mote cancer metastasis. Nature 2010;464:1071–6.
35. Chen WM, Chen WD, Jiang XM, Jia XF, Wang HM, Zhang QJ, et al. HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer. World J Gastroenterol 2017;23:6100–10.
36. Nasrollahzadeh-Khakiani M, Emadi-Baygi M, Nikpour P. Augmented expression levels of lncRNAs ecCEBPA and UCA1 in gastric cancer tissues and their clinical significance. Iran J Basic Med Sci 2017;20:1149–58.
37. Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res 2006;12:4851–8.
38. Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;117:89–95.
39. Liu SP, Yang JX, Cao DY, Shen K. Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med 2013;10:138–41.
40. Tian Y, Zhang X, Hao Y, Fang Z, He Y. Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res 2014;24:335–41.
41. Gao ZQ, Wang JF, Chen DH, Ma XS, Wu Y, Tang Z, et al. Long noncoding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis. Cell Biosci 2017;7:66.
42. Li J, Wang Y, Zhang CG, Xiao, Xiao HJ, Hu, Hou JM, et al. Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line. Cancer Cell Int 2018;18:4.
43. Tang J, Zhuo H, Zhang X, Jiang R, Ji J, Deng L, et al. A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. Cell Death Dis 2014;5:e1549.
44. Amit D, Hochberg A. Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. J Transl Med 2010;8:134.
45. Kimura T, Aikata H, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, et al. Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies. Hepatol Res 2015;45:378–86.
46. Li Z, Dou P, Liu T, He S. Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets. Cell Physiol Biochem 2017;42:1407–19.
47. Hongay CF, Grisafi PL, Galitski T, Fink GR. Antisense transcription controls cell fate in Saccharomyces cerevisiae. Cell 2006;127:735–45.
48. Hainer SJ, Charsar BA, Cohen SB, Martens JA. Identification of Mutant Versions of the Spt16 Histone Chaperone That Are Defective for Transcription-Coupled Nucleosome Occupancy in Saccharomyces cerevisiae. G3 (Bethesda) 2012;2:555–67.
49. Fang Y, Fullwood MJ. Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics Proteomics Bioinformatics 2016;14:42–54.

APA	GÜZEL E, OKYAY T, Yalçınkaya B, KARACAOĞLU Ş, GÖÇMEN M, AKÇAKUYU M (2020). Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. , 81 - 86. 10.14744/nci.2019.46873
Chicago	GÜZEL Esra,OKYAY Tuğba Muhlise,Yalçınkaya Burhanettin,KARACAOĞLU Şeymanur,GÖÇMEN Melek,AKÇAKUYU Muhammed Hüseyin Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. (2020): 81 - 86. 10.14744/nci.2019.46873
MLA	GÜZEL Esra,OKYAY Tuğba Muhlise,Yalçınkaya Burhanettin,KARACAOĞLU Şeymanur,GÖÇMEN Melek,AKÇAKUYU Muhammed Hüseyin Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. , 2020, ss.81 - 86. 10.14744/nci.2019.46873
AMA	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. . 2020; 81 - 86. 10.14744/nci.2019.46873
Vancouver	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. . 2020; 81 - 86. 10.14744/nci.2019.46873
IEEE	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M "Tumor suppressor and oncogenic role of long non-coding RNAs in cancer." , ss.81 - 86, 2020. 10.14744/nci.2019.46873
ISNAD	GÜZEL, Esra vd. "Tumor suppressor and oncogenic role of long non-coding RNAs in cancer". (2020), 81-86. https://doi.org/10.14744/nci.2019.46873

APA	GÜZEL E, OKYAY T, Yalçınkaya B, KARACAOĞLU Ş, GÖÇMEN M, AKÇAKUYU M (2020). Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri, 7(1), 81 - 86. 10.14744/nci.2019.46873
Chicago	GÜZEL Esra,OKYAY Tuğba Muhlise,Yalçınkaya Burhanettin,KARACAOĞLU Şeymanur,GÖÇMEN Melek,AKÇAKUYU Muhammed Hüseyin Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri 7, no.1 (2020): 81 - 86. 10.14744/nci.2019.46873
MLA	GÜZEL Esra,OKYAY Tuğba Muhlise,Yalçınkaya Burhanettin,KARACAOĞLU Şeymanur,GÖÇMEN Melek,AKÇAKUYU Muhammed Hüseyin Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri, vol.7, no.1, 2020, ss.81 - 86. 10.14744/nci.2019.46873
AMA	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri. 2020; 7(1): 81 - 86. 10.14744/nci.2019.46873
Vancouver	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri. 2020; 7(1): 81 - 86. 10.14744/nci.2019.46873
IEEE	GÜZEL E,OKYAY T,Yalçınkaya B,KARACAOĞLU Ş,GÖÇMEN M,AKÇAKUYU M "Tumor suppressor and oncogenic role of long non-coding RNAs in cancer." İstanbul Kuzey Klinikleri, 7, ss.81 - 86, 2020. 10.14744/nci.2019.46873
ISNAD	GÜZEL, Esra vd. "Tumor suppressor and oncogenic role of long non-coding RNAs in cancer". İstanbul Kuzey Klinikleri 7/1 (2020), 81-86. https://doi.org/10.14744/nci.2019.46873