TY  - JOUR
TI  - Tumor suppressor and oncogenic role of long non-coding RNAs in cancer
AB  - Non-coding RNAs are RNA molecules that are not translated into the protein, making up the vast majority of the humangenome. Long non-coding RNAs (lncRNA) are in the RNA group that has longer than 200 nucleotides, and non-protein coding transcripts. In recent years, the potential has attracted considerable attention as new important biological regulators.LncRNAs play a critical role in regulating the activity and localization of proteins, processing the production of small RNAs, andprocessing other RNAs. They are also involved in cell differentiation, cell cycle, proliferation, apoptosis, migration and invasion by modulation of gene expression. Abnormal expression of LncRNAs has an important role in the function of oncogenesand tumor suppressor genes. Recently, there has been an increasing number of studies on the tumorigenic effects of specificlncRNAs in the initiation and progression of cancer. In this review, general information about lncRNAs is provided, includingthe biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications.
AU  - GÖÇMEN, Melek
AU  - KARACAOĞLU, Şeymanur
AU  - OKYAY, Tuğba Muhlise
AU  - Yalçınkaya, Burhanettin
AU  - GÜZEL, Esra
AU  - AKÇAKUYU, Muhammed Hüseyin
DO  - 10.14744/nci.2019.46873
PY  - 2020
JO  - İstanbul Kuzey Klinikleri
VL  - 7
IS  - 1
SN  - 2148-4902
SP  - 81
EP  - 86
DB  - TRDizin
UR  - http://search/yayin/detay/357575
ER  -