TY  - JOUR
TI  - The effect of low and high dose empagliflozin on HbA1c and lipid profile in type 2 diabetes mellitus: A real-world data
AB  - OBJECTIVE: This study aims to evaluate the efficacy and safety of the addition of 10 or 25 mg of empagliflozin to patientswith type 2 diabetes mellitus using a maximum tolerable dose of metformin and gliclazide.METHODS: A total of 60 patients who had been receiving a maximum tolerable dose of metformin plus gliclazide. wasdivided into two groups in this study. In the first group (Group 1, n=32), 10 mg empagliflozin was added to the current treatment once a day, and in the second group (Group 2, n=28) 25 mg empagliflozin was added to the same treatment once a day.Biochemical results, weight and blood pressure changes of the patients in both groups were evaluated before and after 12weeks of empagliflozin addition. Patients who developed urinary tract and genital infections after treatment were recorded.RESULTS: There was a statistically significant decrease in HbA1c in both groups after empagliflozin treatment (Group 1,p<0.001 and Group2, p=0.001). When the lipid profile was evaluated, no significant difference was found between basaland post-treatment parameters (p>0.05). Patients in Group 1 and Group 2 lost 2.6±1.2 and 3.8±2.0 kg of body weight,respectively (p<0.0001 for each). There were also significant reductions in systolic and diastolic blood pressure for groups 1and 2 (p<0.0001 for each). Although there was a numerical increase in the urinary tract and genital infections in both groupsafter empagliflozin treatment, there was no statistically significant difference compared to the pre-treatment period (p>0.05).CONCLUSION: Two doses of empagliflozin added to the present treatments showed a dose-independent improvement inglycemic control and a neutral effect on lipid metabolism.
AU  - VURAL, AŞKI
AU  - Özçelik, Serhat
AU  - Celik, Mehmet
AU  - Aydın, Bünyamin
DO  - 10.14744/nci.2019.22697
PY  - 2020
JO  - İstanbul Kuzey Klinikleri
VL  - 7
IS  - 2
SN  - 2148-4902
SP  - 167
EP  - 173
DB  - TRDizin
UR  - http://search/yayin/detay/357675
ER  -