Yıl: 2019 Cilt: 26 Sayı: 11 Sayfa Aralığı: 2513 - 2519 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.09.591 İndeks Tarihi: 23-09-2020

Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection

Öz:
Aim: In this study, we aimed to determine the clinical value of neutrophil / lymphocyte ratio (NLR) in predicting postoperativecomplications, lymph node positivity and prognosis in patients who underwent curative surgical resection.Material and Methods: Patients who underwent total gastrectomy for gastric adenocarcinoma between 2015 and 2018 wereincluded in the study. Two groups, Group 1 (LowNLR) and Group 2 (HighNLR), were formed. Demographic and clinical characteristics,intraoperative and postoperative outcomes, and mean survival were compared. The value of NLR in predicting lymph node positivityand postoperative complications was evaluated at the cutoff value determined for NLR.Results: Patients were divided into two groups according to the cutoff value of 2.14. Group 1 consisted of 36 patients and Group 2consisted of 68 patients. Female sex was higher in Group 2 (72% vs 52%) (p:0.41). Postoperative complication rates according toClavien Dindo classification were similar (p:0.9). The number of dissected positive lymph nodes was higher in Group 2 than in Group1 (9 vs 6) (p:0.041). Pathological stage (p:0.188), and overall survival (24.61vs21.12,p:0.206) were similar between the groups. Wefound NLR as a risk factor for survival in multivariate analysis (HR=0.255, 95%CI: 0.024–0.427, p:0.029). If the NLR value was lessthan 2.14, the patient had According to Clavien Dindo classification Grade 2 and above complications, with a sensitivity of 46.3% andspecificity of 76.0%. A positive lymph node was detected with 44.26% sensitivity and 65.12% specificity.Conclusion: Preoperative high NLR is a risk factor for survival in patients with gastric cancer. High NLR is also closely associatedwith the risk of postoperative complications.
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APA Yalav O, topal u, Unal A (2019). Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. , 2513 - 2519. 10.5455/annalsmedres.2019.09.591
Chicago Yalav Orcun,topal uğur,Unal Ayse Gizem Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. (2019): 2513 - 2519. 10.5455/annalsmedres.2019.09.591
MLA Yalav Orcun,topal uğur,Unal Ayse Gizem Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. , 2019, ss.2513 - 2519. 10.5455/annalsmedres.2019.09.591
AMA Yalav O,topal u,Unal A Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. . 2019; 2513 - 2519. 10.5455/annalsmedres.2019.09.591
Vancouver Yalav O,topal u,Unal A Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. . 2019; 2513 - 2519. 10.5455/annalsmedres.2019.09.591
IEEE Yalav O,topal u,Unal A "Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection." , ss.2513 - 2519, 2019. 10.5455/annalsmedres.2019.09.591
ISNAD Yalav, Orcun vd. "Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection". (2019), 2513-2519. https://doi.org/10.5455/annalsmedres.2019.09.591
APA Yalav O, topal u, Unal A (2019). Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. Annals of Medical Research, 26(11), 2513 - 2519. 10.5455/annalsmedres.2019.09.591
Chicago Yalav Orcun,topal uğur,Unal Ayse Gizem Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. Annals of Medical Research 26, no.11 (2019): 2513 - 2519. 10.5455/annalsmedres.2019.09.591
MLA Yalav Orcun,topal uğur,Unal Ayse Gizem Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. Annals of Medical Research, vol.26, no.11, 2019, ss.2513 - 2519. 10.5455/annalsmedres.2019.09.591
AMA Yalav O,topal u,Unal A Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. Annals of Medical Research. 2019; 26(11): 2513 - 2519. 10.5455/annalsmedres.2019.09.591
Vancouver Yalav O,topal u,Unal A Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection. Annals of Medical Research. 2019; 26(11): 2513 - 2519. 10.5455/annalsmedres.2019.09.591
IEEE Yalav O,topal u,Unal A "Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection." Annals of Medical Research, 26, ss.2513 - 2519, 2019. 10.5455/annalsmedres.2019.09.591
ISNAD Yalav, Orcun vd. "Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection". Annals of Medical Research 26/11 (2019), 2513-2519. https://doi.org/10.5455/annalsmedres.2019.09.591