TY  - JOUR
TI  - Clinical value of neutrophil/lymphocyte ratio in predicting postoperative complications, lymph node positivity and prognosis in gastric cancer patients who underwent curative surgical resection
AB  - Aim: In this study, we aimed to determine the clinical value of neutrophil / lymphocyte ratio (NLR) in predicting postoperativecomplications, lymph node positivity and prognosis in patients who underwent curative surgical resection.Material and Methods: Patients who underwent total gastrectomy for gastric adenocarcinoma between 2015 and 2018 wereincluded in the study. Two groups, Group 1 (LowNLR) and Group 2 (HighNLR), were formed. Demographic and clinical characteristics,intraoperative and postoperative outcomes, and mean survival were compared. The value of NLR in predicting lymph node positivityand postoperative complications was evaluated at the cutoff value determined for NLR.Results: Patients were divided into two groups according to the cutoff value of 2.14. Group 1 consisted of 36 patients and Group 2consisted of 68 patients. Female sex was higher in Group 2 (72% vs 52%) (p:0.41). Postoperative complication rates according toClavien Dindo classification were similar (p:0.9). The number of dissected positive lymph nodes was higher in Group 2 than in Group1 (9 vs 6) (p:0.041). Pathological stage (p:0.188), and overall survival (24.61vs21.12,p:0.206) were similar between the groups. Wefound NLR as a risk factor for survival in multivariate analysis (HR=0.255, 95%CI: 0.024–0.427, p:0.029). If the NLR value was lessthan 2.14, the patient had According to Clavien Dindo classification Grade 2 and above complications, with a sensitivity of 46.3% andspecificity of 76.0%. A positive lymph node was detected with 44.26% sensitivity and 65.12% specificity.Conclusion: Preoperative high NLR is a risk factor for survival in patients with gastric cancer. High NLR is also closely associatedwith the risk of postoperative complications.
AU  - topal, uğur
AU  - Yalav, Orcun
AU  - Unal, Ayse Gizem
DO  - 10.5455/annalsmedres.2019.09.591
PY  - 2019
JO  - Annals of Medical Research
VL  - 26
IS  - 11
SN  - 2636-7688
SP  - 2513
EP  - 2519
DB  - TRDizin
UR  - http://search/yayin/detay/358441
ER  -