Aim: The prevalence of Helicobacter Pylori (HP) is up to 90% in developing countries, whereas it is less than 40% in developedcountries. This study aims to determine the prevalence of HP in Van city and its region and to investigate the relationship betweenthe presence of HP and the clinical, endoscopic appearanceMaterial and Methods: A total of 367 cases that presented with the dyspeptic complaints to the Gastroenterology outpatient-clinicand underwent upper-gastrointestinal endoscopy and gastric biopsies between July/2017-March/2019 were included in the study.The patients included in the study were divided into three age-groups (1-5 years, 6-10 years, 11-18 years). The clinical complaints,endoscopic findings were recorded in all patients. The relationship between HP positivity and clinical complaints, the endoscopicappearance was analyzed.Results: The presence of HP was found in 234(63.8%) patients. However, the incidence of HP was 63.8% in all patients; it was found34.6% between 1-5 years, 61.8% between 6-10 years, and 71.2% between 11-18 years, respectively. The duodenal ulcer was found in8.5%(20/234) of HP positive cases, and 3.5%(5/133) of HP negative cases. In predicting the presence of HP, the ulcer specificity wasdetermined 96%, the sensitivity was 8.5%, the positive predictive value was 80%, and the negative predictive value was found 37.4%Conclusion: HP should be considered in patients with recurrent and chronic abdominal pain. Endoscopic appearance of nodularantral gastritis and the ulcer should suggest HP infection. The high rate of activity and chronicity in HP positive cases indicates theimportance of HP eradication therapy.