TY  - JOUR
TI  - The relationship between homocysteine and autoimmune subclinical hypothyroidism
AB  - Objectives: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and autoimmunity.The aim of this study was to investigate the association between the homocysteine level, lipid parameters,high-sensitivity C-reactive protein (hs-CRP), and autoantibodies in subclinical hypothyroid patients.Methods: A total of 100 cases, 50 patients who were older than 18 years of age and diagnosed with subclinical hypothyroidismdue to Hashimoto’s thyroiditis and 50 controls with no known disease, were included in the study.Results: Homocysteine (9.6 μmol/L vs 5.5 μmol/L; p<0.001), hs-CRP (2.4 mg/L vs 0.9 mg/L; p<0.001), and low-densitylipoprotein-cholesterol levels (115.9±32.7 mg/dL vs 100.3±23.9 mg/dL) (p=0.008) were determined to be higher in thesubclinical hypothyroidism group, and the high-density lipoprotein (HDL) cholesterol level (51.2±12.7 mg/dL vs 58.8±15.2mg/dL; p=0.008) was lower in the subclinical hypothyroidism group compared with the healthy control group. A positivecorrelation was determined between the homocysteine level and the hs-CRP (r=0.312; p=0.027), anti-thyroid peroxidase(r=0.505; p<0.001), and anti-thyroglobulin (r=0.318; p=0.031) levels in the subclinical hypothyroidism group.Conclusion: In the regression analysis performed, HDL cholesterol, hs-CRP, and homocysteine levels were each foundto be an independent risk factor for subclinical hypothyroidism. Our results indicated that homocysteine was associatedwith subclinical hypothyroidism.
AU  - TURHAN, Turan
AU  - Ates, Ihsan
AU  - bolal, mehmet
AU  - yılmaz, nisbet
AU  - ALTAY, Mustafa
AU  - Demir, Burak
DO  - 10.14744/ijmb.2019.13008
PY  - 2020
JO  - International Journal of Medical Biochemistry
VL  - 3
IS  - 1
SN  - 2587-2362
SP  - 1
EP  - 7
DB  - TRDizin
UR  - http://search/yayin/detay/358649
ER  -