Yıl: 2018 Cilt: 19 Sayı: 3 Sayfa Aralığı: 628 - 636 Metin Dili: İngilizce DOI: 10.18038/aubtda.384666 İndeks Tarihi: 28-09-2020

CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES

Öz:
Ferulic acid (FA), or 4-hydroxy-3-methoxycinnamic acid, is a phenolic compound that can be used in many pharmacologicalapplications, especially in the area of cancer. In this study, four new FA-quinoline esters were successfully synthesized andcharacterized using 1H-NMR, 13C-NMR, HR-Mass, Elemental Analysis, and FT-IR techniques. Synthesized compounds weretested on leukemia cell lines (HL-60 and K562) with WST-1 assay and Annexin V-PI assay via flow cytometry. The WST-1assay of compounds in HL-60 and K562 leukemia cells yielded IC50 124.4 and 205.4 μM/mL, respectively. According to theresults, both the cytotoxic effect and apoptotic effects of 2c increased on HL-60 cell.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÜNVER H, Canturk Z (2018). CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. , 628 - 636. 10.18038/aubtda.384666
Chicago ÜNVER HAKAN,Canturk Zerrin CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. (2018): 628 - 636. 10.18038/aubtda.384666
MLA ÜNVER HAKAN,Canturk Zerrin CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. , 2018, ss.628 - 636. 10.18038/aubtda.384666
AMA ÜNVER H,Canturk Z CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. . 2018; 628 - 636. 10.18038/aubtda.384666
Vancouver ÜNVER H,Canturk Z CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. . 2018; 628 - 636. 10.18038/aubtda.384666
IEEE ÜNVER H,Canturk Z "CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES." , ss.628 - 636, 2018. 10.18038/aubtda.384666
ISNAD ÜNVER, HAKAN - Canturk, Zerrin. "CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES". (2018), 628-636. https://doi.org/10.18038/aubtda.384666
APA ÜNVER H, Canturk Z (2018). CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, 19(3), 628 - 636. 10.18038/aubtda.384666
Chicago ÜNVER HAKAN,Canturk Zerrin CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering 19, no.3 (2018): 628 - 636. 10.18038/aubtda.384666
MLA ÜNVER HAKAN,Canturk Zerrin CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, vol.19, no.3, 2018, ss.628 - 636. 10.18038/aubtda.384666
AMA ÜNVER H,Canturk Z CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering. 2018; 19(3): 628 - 636. 10.18038/aubtda.384666
Vancouver ÜNVER H,Canturk Z CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering. 2018; 19(3): 628 - 636. 10.18038/aubtda.384666
IEEE ÜNVER H,Canturk Z "CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES." Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, 19, ss.628 - 636, 2018. 10.18038/aubtda.384666
ISNAD ÜNVER, HAKAN - Canturk, Zerrin. "CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES". Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering 19/3 (2018), 628-636. https://doi.org/10.18038/aubtda.384666