TY  - JOUR
TI  - PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE
AB  - The essential oil of Achillea grandifolia Friv. was obtained by hydrodistillation of aerial parts of the plant and analyzed withGC-FID and GC/MS techniques. The oil comprised mostly by the oxygenated monoterpenes (76.2 %) with $alpha$-terpinyl acetate(54.1 %) as main constituent. The monoterpene hydrocarbons were the second major compound group with p-cymene (17.7%) as the main representative. The essential oil showed free radical scavenging activity against DPPH•radicals (Inh. 52 %) andABTS+• cation radicals (TEAC 0.62 mM). The oil demonstrated hypoglycemic activity via inhibition of $alpha$ amylase (${IC}_{50}$ 0.15mg/mL). The effect of the oil on neurodegenerative disease was expressed via inhibition of acetylcholinesterase (AChE) andfound to be > 82 % of inhibition (an ${IC}_{50}$ of 1.77 mg/mL).
AU  - ÖZEK, Gülmira
DO  - 10.18038/aubtda.392366
PY  - 2018
JO  - Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering
VL  - 19
IS  - 3
SN  - 2667-4211
SP  - 671
EP  - 684
DB  - TRDizin
UR  - http://search/yayin/detay/359164
ER  -