Objectives: This study aims to present our mid-term experience of treating chronic iliac or femoral total occlusions via percutaneoustransluminal angioplasty (PTA).Patients and methods: Between January 2017 and August 2019, this single-center, retrospective study included 45 patients (40 males,5 females; median age 60 years; range, 33 to 81 years) who underwent PTA due to chronic total occlusion.Results: Of the patients, eight had iliac and 37 had superficial femoral artery occlusion. The technical success rate was 95.5% with a meanfollow-up period 17.2±0.4 months. Bail-out stenting was required in 10 (22.2%) of the lesions and only seven patients (15.5%) neededpercutaneous reintervention at the end of follow-up. Following endovascular interventions, one patient (2.2%) developed seroma, while two(4.4%) developed infections and one (2.2.%) developed a pseudoaneurysm of the femoral artery. Three patients (6.6%) underwent femoropopliteal bypass. A total of 42 patients completed the follow-up. The Kaplan-Meier analysis revealed a primary patency rate of 83.3% andfreedom from reintervention of 95.2% during 17-month follow-up.Conclusion: The endovascular treatment strategy of chronic total occlusions of the iliac and femoral arteries is acceptable with less morbidityand good patency rates. Cardiovascular surgeons should be encouraged in the field of endovascular treatment of peripheral arterial diseaseincluding chronic total occlusions.