TY  - JOUR
TI  - Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study
AB  - ABSTRACTBACKGROUND: To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS).METHODS: A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups.RESULTS: Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30- and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels.CONCLUSION: IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS.
AU  - ACAR, Sami
AU  - TÜREDİ, Süleyman
AU  - AKÇA, Metehan
AU  - YILDIRIM, Mehmet
AU  - ÇEKIÇ, ARIF BURAK
AU  - Mentese, Ahmet
AU  - Demir, Selim
AU  - Sahin, Aynur
AU  - KÖSE, Gökçen Derya REİS
AU  - TÜRKMEN, Süha
AU  - YULUĞ, Ersin
DO  - 10.14744/tjtes.2019.32754
PY  - 2020
JO  - Ulusal Travma ve Acil Cerrahi Dergisi
VL  - 26
IS  - 2
SN  - 1306-696X
SP  - 153
EP  - 162
DB  - TRDizin
UR  - http://search/yayin/detay/360106
ER  -