Lokal ve Sistemik Renin Anjiyotensin Sistemi
Yıl: 2019 Cilt: 28 Sayı: 4 Sayfa Aralığı: 259 - 269 Metin Dili: Türkçe DOI: 10.17827/aktd.495976 İndeks Tarihi: 06-10-2020
Lokal ve Sistemik Renin Anjiyotensin Sistemi
Öz: Renin Anjiyotensin Sisteminin (RAS) atheroskleroz ve hipertansiyon gibi kardiyovasküler hastalıklarınfizyopatolojisinde önemli rol oynadığı bildirilmektedir. Vasküler düz kas ve endotel hücresinin RAS, lipoproteinler veinsülinle etkileşimi, diyabet, miyokart enfarktüs, hipertansiyon, inme ve stent restenozu gibi hastalıkların gelişimine veilerlemesine neden olarak gösterilmektedir. Sistemik RAS daha çok kan basıncının düzenlenmesini, tuz ve su alımını,antidiüretik hormon (ADH) salınımını sağlarken, lokal RAS vasküler düz kas hücrelerinin çoğalması, büyümesi,apopitoz ve inflamasyonunda görev almaktadır. Çalışmalarda, RAS bileşenlerinin vasküler düz kas, kalp hücresi, yağdokusu ve beyin gibi birçok yerde lokal olarak sentezlendiği gösterilmiştir. Vasküler yapı üzerine hem sistemik hem delokal olarak sentez edilip etki gösteren RAS’ın patolojik süreçlerdeki intrasellüler etki mekanizmaları tam olarakaydınlatılamamıştır. Bu yüzden lokal RAS’ın bileşenlerinin tam anlamıyla aydınlatılması yeni tedavi yöntemleriningeliştirilmesinde önemli rol oynayacaktır
Anahtar Kelime: Local and Systemic Renin Angiotensin System
Öz: The Renin Angiotensin System (RAS) has been reported to play an important role in the physiopathology of cardiovascular diseases such as atherosclerosis and hypertension. Interaction of vascular smooth muscle and endothelial cells with RAS, lipoproteins and insulin has been shown to cause the development and progression of diseases such as diabetes, myocardial infarction, hypertension, stroke and stent restenosis. While systemic RAS is mostly responsible for the regulation of blood pressure, salt and water intake, release of antidiuretic hormone (ADH), local RAS plays a role in the proliferation, growth, apoptosis and inflammation of vascular smooth muscle cells. In studies, it has been shown that RAS components are synthesized locally in many places such as vascular smooth muscle, heart cells, fat tissue and brain. Thus, full identification of local RAS components will play an important role in the development of new treatment modalities.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | cicek z, akillioglu k, dogan a (2019). Lokal ve Sistemik Renin Anjiyotensin Sistemi. , 259 - 269. 10.17827/aktd.495976 |
| Chicago | cicek zehra,akillioglu kübra,dogan ayse Lokal ve Sistemik Renin Anjiyotensin Sistemi. (2019): 259 - 269. 10.17827/aktd.495976 |
| MLA | cicek zehra,akillioglu kübra,dogan ayse Lokal ve Sistemik Renin Anjiyotensin Sistemi. , 2019, ss.259 - 269. 10.17827/aktd.495976 |
| AMA | cicek z,akillioglu k,dogan a Lokal ve Sistemik Renin Anjiyotensin Sistemi. . 2019; 259 - 269. 10.17827/aktd.495976 |
| Vancouver | cicek z,akillioglu k,dogan a Lokal ve Sistemik Renin Anjiyotensin Sistemi. . 2019; 259 - 269. 10.17827/aktd.495976 |
| IEEE | cicek z,akillioglu k,dogan a "Lokal ve Sistemik Renin Anjiyotensin Sistemi." , ss.259 - 269, 2019. 10.17827/aktd.495976 |
| ISNAD | cicek, zehra vd. "Lokal ve Sistemik Renin Anjiyotensin Sistemi". (2019), 259-269. https://doi.org/10.17827/aktd.495976 |
| APA | cicek z, akillioglu k, dogan a (2019). Lokal ve Sistemik Renin Anjiyotensin Sistemi. Arşiv Kaynak Tarama Dergisi, 28(4), 259 - 269. 10.17827/aktd.495976 |
| Chicago | cicek zehra,akillioglu kübra,dogan ayse Lokal ve Sistemik Renin Anjiyotensin Sistemi. Arşiv Kaynak Tarama Dergisi 28, no.4 (2019): 259 - 269. 10.17827/aktd.495976 |
| MLA | cicek zehra,akillioglu kübra,dogan ayse Lokal ve Sistemik Renin Anjiyotensin Sistemi. Arşiv Kaynak Tarama Dergisi, vol.28, no.4, 2019, ss.259 - 269. 10.17827/aktd.495976 |
| AMA | cicek z,akillioglu k,dogan a Lokal ve Sistemik Renin Anjiyotensin Sistemi. Arşiv Kaynak Tarama Dergisi. 2019; 28(4): 259 - 269. 10.17827/aktd.495976 |
| Vancouver | cicek z,akillioglu k,dogan a Lokal ve Sistemik Renin Anjiyotensin Sistemi. Arşiv Kaynak Tarama Dergisi. 2019; 28(4): 259 - 269. 10.17827/aktd.495976 |
| IEEE | cicek z,akillioglu k,dogan a "Lokal ve Sistemik Renin Anjiyotensin Sistemi." Arşiv Kaynak Tarama Dergisi, 28, ss.259 - 269, 2019. 10.17827/aktd.495976 |
| ISNAD | cicek, zehra vd. "Lokal ve Sistemik Renin Anjiyotensin Sistemi". Arşiv Kaynak Tarama Dergisi 28/4 (2019), 259-269. https://doi.org/10.17827/aktd.495976 |
