Yıl: 2020 Cilt: 27 Sayı: 5 Sayfa Aralığı: 1415 - 1421 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.12.828 İndeks Tarihi: 08-10-2020

Our surgical experience in cholangiocellular carcinoma

Öz:
Aim: Cholangiocellular carcinomas are rare bile duct tumors. They are categorized as intrahepatic(iCCA), perihilar(pCCA) ordistal(dCCA) cholangiocarcinomas according to their anatomical location. In this study, we aimed to present our clinical experiencein patients with cholangiocellular carcinoma.Material and Methods: Patients who underwent curative surgery with the diagnosis of cholangiocellular carcinoma between 2010and 2019 were retrospectively reviewed. Demographic and clinical characteristics, surgical procedures, tumor characteristics, shortand long-term results and survival of the patients were analyzed.Results: Twentynine patients were included in the study. The mean age of the patients was 63.3(±10.8) years, and 52% of the patientswere older than 65 years. Male sex was 79.3%. Percutaneous biliary drainage was performed in 52% of the patients before theoperation. Tumor localizations were distal (dCCA) in 12 (41.4%) patients, perihilar (pCCA) in 11 (38%) patients, and intrahepatic (iCCA)in 6 (20.6%) patients. Only biliary resection was performed in 69%, hepatic + biliary resection in 27.6%, and only hepatic resectionin 3.4% of the patients. The mean tumor size was 3.08 cm (±1.91), tumor stage was commonly stage II (58.6%) and postoperativecomplication was seen in 13.8% of the patients. Ninety-day unplanned readmission was observed in 31.3%, postoperative mortalityin 6.9%, and recurrence during postoperative follow-up in 24.2% of the patients. The mean survival time was 22.82(±13.72) months.Conclusion: The type of surgical approach to be performed in cholangiocellular carcinoma is related to the localization of the tumor.With the right patient selection, curative surgical treatment can be performed at low morbidity and mortality rates.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Olnes MJ, Erlich R. A reviewandupdate on cholangiocarcinoma.Oncology 2004;66:167-79
  • 2. Razumilava N, Gores GJ. Cholangiocarcinoma. The Lancet 2014;3832168-79.
  • 3. Lewis HL, Rahnemai-Azar AA, Dillhoff M, et al. Current management of perihilar cholangiocarcinoma and future perspectives. Chirurgia 2017;112:193-207.
  • 4. Khan SA, Thomas HC, Davidson B R, et al. Cholangiocarcinoma. The Lancet 2005;366:1303-14.
  • 5. Bergquist A, vonSeth E. Epidemiology of cholangiocarcinoma. Best Pract Res Clin Gastroenterol 2015;29:221-32.
  • 6. Hidalgo E, Asthana S, Nishio H, et al. Surgeryforhilarcholangiocarcinoma: the Leeds experience. Eur J Surg Oncol 2008;34:787-94.
  • 7. Silva MA, Tekin K, Aytekin F, et al Surgery for hilar cholangiocarcinoma; a 10 year experience of a tertiary referral centre in the UK. Eur J Surg Oncol 2005;31:533-9.
  • 8. Neumann UP, Schmeding M. Role of surgeryin cholangiocarcinoma: from resection to transplantation. Best Pract Res Clin Gastroenterol 2015;29:295-308.
  • 9. Lee SG, Song GW, Hwang S, et al. Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 2010;17: 476-89.
  • 10. Cillo U, Fondevila C, Donadon M, et al. Surgery for cholangio carcinoma. Liver Int 2019;39:143-55.
  • 11. DeOliveira ML, Cunningham SC, Cameron JL,et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 2007;245:755-62.
  • 12. Ahrendt SA, Pitt HA. Biliary tract. In: Townsend C, editor.Sabiston Textbook of Surgery. Philadelphia: W.B. Saunders Company 2001:1076-11.
  • 13. Everhart JE, Ruhl CE. Burden of digestive diseases in the UnitedStates Part III: Liver, biliary tract, and pancreas. Gastroenterology 2009;136:1134-44.
  • 14. Anderson CD, Pinson CW, Berlin J, et al. Diagnosis and treatment of cholangiocarcinoma. The oncologist 2004;9:43-57.
  • 15. 1RARECARE project, Surveillance of Rare Cancers in Europe. Incidence (1995–2002)in Europe by sex, age, and EU region with expected new case in EU (27) in 2008 Available at: http://dcnapp4. dcn.ed.ac.uk/rcnet/searchpage.aspx.
  • 16. Squadroni M, Tondulli L, Gatta G, et al. Cholangiocarcinoma. Crit Rev Oncol Hematol 2017;116:11-31.
  • 17. Kimmings AN, van Deventer SJ, Obertop H, et al. Inflammatory and immunologic effects of obstructive jaundice: pathogenesis and treatment. J Am Coll Surg 1995;181:567-81.
  • 18. Hu QL, Liu JB, Ellis RJ, et al Association of preoperative biliary drainage technique with postoperative outcomes among patients with resectable hepatobiliary malignancy. HPB 2019.
  • 19. Rizvi S, Khan SA, Hallemeier CL, et al. Cholangiocarcinoma—evolving concepts and therapeutic strategies. Nat Rev Clin Oncol 2018;15:95- 111.
  • 20. Farges O, RegimbeauJm, Fuks D, et al. Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma. Br J Surg 2013;100:274- 83.
  • 21. Nuzzo G, Giuliante F, Ardito F, et al. Improvement in perioperative and long-term outcome after surgical treatment of hilar cholangiocarcinoma results of an Italian multicenter analysis of 440 patients. Arch Surg 2012;147:26-34.
  • 22. Nakeeb A, Pitt HA , Sohn TA , et al . Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 1996;224:463-75.
  • 23. Nagino M, Ebata T, Yokoyama Y, et al. Evolution of surgical treatment for perihilar cholangiocarcinoma: A single center 34-year review of 574 consecutive resections. Ann Surg 2013;258:129-40.
  • 24. Bhardwaj N, Garcea G, Dennison AR, et al. The surgical management of klatskin tumours: has anything changed in the lastdecade? World J Surg 2015;39:2748-56.
  • 25. Groot Koerkamp B, Fong Y. Outcomes in biliary malignancy. J SurgOncol 2014;110:585-91.
APA Saritas A, Ülkü A, topal u, Dalcı K, AYDIN E, Akcam A (2020). Our surgical experience in cholangiocellular carcinoma. , 1415 - 1421. 10.5455/annalsmedres.2019.12.828
Chicago Saritas Ahmet Gokhan,Ülkü Abdullah,topal uğur,Dalcı Kubilay,AYDIN Erdi,Akcam Atilgan Tolga Our surgical experience in cholangiocellular carcinoma. (2020): 1415 - 1421. 10.5455/annalsmedres.2019.12.828
MLA Saritas Ahmet Gokhan,Ülkü Abdullah,topal uğur,Dalcı Kubilay,AYDIN Erdi,Akcam Atilgan Tolga Our surgical experience in cholangiocellular carcinoma. , 2020, ss.1415 - 1421. 10.5455/annalsmedres.2019.12.828
AMA Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A Our surgical experience in cholangiocellular carcinoma. . 2020; 1415 - 1421. 10.5455/annalsmedres.2019.12.828
Vancouver Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A Our surgical experience in cholangiocellular carcinoma. . 2020; 1415 - 1421. 10.5455/annalsmedres.2019.12.828
IEEE Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A "Our surgical experience in cholangiocellular carcinoma." , ss.1415 - 1421, 2020. 10.5455/annalsmedres.2019.12.828
ISNAD Saritas, Ahmet Gokhan vd. "Our surgical experience in cholangiocellular carcinoma". (2020), 1415-1421. https://doi.org/10.5455/annalsmedres.2019.12.828
APA Saritas A, Ülkü A, topal u, Dalcı K, AYDIN E, Akcam A (2020). Our surgical experience in cholangiocellular carcinoma. Annals of Medical Research, 27(5), 1415 - 1421. 10.5455/annalsmedres.2019.12.828
Chicago Saritas Ahmet Gokhan,Ülkü Abdullah,topal uğur,Dalcı Kubilay,AYDIN Erdi,Akcam Atilgan Tolga Our surgical experience in cholangiocellular carcinoma. Annals of Medical Research 27, no.5 (2020): 1415 - 1421. 10.5455/annalsmedres.2019.12.828
MLA Saritas Ahmet Gokhan,Ülkü Abdullah,topal uğur,Dalcı Kubilay,AYDIN Erdi,Akcam Atilgan Tolga Our surgical experience in cholangiocellular carcinoma. Annals of Medical Research, vol.27, no.5, 2020, ss.1415 - 1421. 10.5455/annalsmedres.2019.12.828
AMA Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A Our surgical experience in cholangiocellular carcinoma. Annals of Medical Research. 2020; 27(5): 1415 - 1421. 10.5455/annalsmedres.2019.12.828
Vancouver Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A Our surgical experience in cholangiocellular carcinoma. Annals of Medical Research. 2020; 27(5): 1415 - 1421. 10.5455/annalsmedres.2019.12.828
IEEE Saritas A,Ülkü A,topal u,Dalcı K,AYDIN E,Akcam A "Our surgical experience in cholangiocellular carcinoma." Annals of Medical Research, 27, ss.1415 - 1421, 2020. 10.5455/annalsmedres.2019.12.828
ISNAD Saritas, Ahmet Gokhan vd. "Our surgical experience in cholangiocellular carcinoma". Annals of Medical Research 27/5 (2020), 1415-1421. https://doi.org/10.5455/annalsmedres.2019.12.828