GÜNCEL BİR ADİPOKİN: CHEMERİN

ÇELİK, Menşure Nur; SÖĞÜT, Mehtap Ünlü

GÜNCEL BİR ADİPOKİN: CHEMERİN

Menşure Nur ÇELİK, (Ondokuz Mayıs Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Samsun, Türkiye)

Mehtap Ünlü SÖĞÜT (Ondokuz Mayıs Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Samsun, Türkiye)

Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi

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Yıl: 2019 Cilt: 20 Sayı: 2 Sayfa Aralığı: 98 - 104 Metin Dili: Türkçe İndeks Tarihi: 08-10-2020

GÜNCEL BİR ADİPOKİN: CHEMERİN

Öz:

Adipoz dokudan salgılanan chemerin kısa bir süreönce adipokin ailesine katılan, çeşitli otokrin ve parakrinetkileri olan bir sinyal molekülü ve yeni bir kemotaktikproteindir. Son yıllarda chemerin ve reseptörünün adipositlerde yüksek oranda olmak üzere karaciğer, böbrek,pankreas, hipofiz, plasenta, yumurtalık ve testislerde eksprese edildiği saptanmıştır. Bu organ ve dokular aracılı-ğıyla enerji homeostazı, glukoz metabolizması, inflmasyon ve birçok fizyolojik sürece etki ettiği bilinmektedir.Adipogenezis, enerji metabolizması ve inflmasyondarolü olduğu gösterilen bu adipokinin metabolik sendrom(MetS), obezite, Tip 2 Diabetes Mellitus (T2DM), kardiyovasküler hastalıklar, Crohn hastalığı, artrit ve kanserderolü hakkında artan kanıtlar mevcuttur. Özellikle chemerin, obezite ile T2DM’ nin gelişimi arasında olası bir bağ-lantının hipotezi olarak öne sürülmüştür. Aynı zamandaplazma chemerin düzeylerinin vücut kütle indeksi, açlıkserum insülini, açlık kan glukozu, plazma trigliseridlerive total serum kolesterolü ile pozitif korelasyon gösterdiği ve yüksek yoğunluklu lipoprotein (HDL) ile negatifkorelasyon gösterdiği saptanmıştır. Genel olarak, bu bulgular dolaşımdaki chemerin düzeylerinin yağlanmaya vemetabolik sendroma bağlı olduğunu, viseral adipozunobez bireylerde chemerinin değiştirilebilir bir kaynağı olduğunu düşündürmektedir. Chemerin; insulin seviyesiniazaltıp, glukoz kullanımını artırarak glukoz homeostazını;glikojen sentetazı inhibe ederek T2DM’u; adiposit farklılaşmasını ve kemotaksisi düzenleyerek inflmasyonu;GLUT-4, yağ asidi sentaz, adiponektin ve leptinin salını-mını düzenleyerek MetS belirteçlerini etkilemektedir. Bunedenle obezite, T2DM, kardiyovasküler hastalıklar, inflamasyon, metabolik sendrom ve daha birçok hastalıklailişkisi bulunan chemerin adipokininin dolaşımdaki seviyelerini belirlemek ve düzeylerini kontrol etmek önemtaşımaktadır. Literatür taramasında sıklıkla obez ve metabolik sendromlu bireylerde dolaşımdaki chemerin seviyelerinin yüksek olduğu göze çarpmaktadır. Bu derlemede chemerinin obezite ve metabolik sendromdaki etkileriile birlikte daha az ele alınan inflmasyon, polikistik oversendromu ve diğer metabolik etkilerine yer verilmektedir.

Anahtar Kelime:

A CURRENT ADIPOKINE: CHEMERIN

Öz:

Chemerin secreted from adipose tissue is a signal molecule with a variety of autocrine and paracrine effcts and a new chemotactic protein that recently joined the adipokine family. In recent years, chemerin and its receptor are expressed at the highest levels in adipocytes and less expressed than in the liver, kidney, pancreas, pituitary, placenta, ovary and testes. Through these organs and tissues it is known that it affcts energy homeostasis, glucose metabolism, inflmmation and many physiological processes. There is growing evidence that this adipokine has been shown to play a role in adipogenesis, energy metabolism and inflmmation, its role in metabolic syndrome (MetS), obesity, Type 2 Diabetes Mellitus (T2DM), cardiovascular diseases, Crohn’s disease, arthritis and cancer. In particular, chemerin has been suggested as a hypothesis of a possible link between obesity and the development of T2DM. It was also found that plasma chemerin levels correlated positively with body mass index, fasting serum insulin, fasting blood glucose, plasma triglycerides and total serum cholesterol and negatively correlated with high density lipoprotein (HDL). In general, these findings indicate that circulating levels of chemerin are dependent on adiposity and metabolic syndrome, suggesting that visceral adipose is a replaceable source of chemerin in obese individuals. Chemerin affcts glucose homeostasis by decreasing insulin levels and increasing glucose uptake; T2DM by inhibiting glycogen synthase; inflmmation by regulating adipocyte diffrentiation and chemotaxis; MetS markers by regulating the release of GLUT-4, fatty acid synthase, adiponectin and leptin. Therefore, it is important to determine the levels of circulating levels of chemerin adipokinin in relation to obesity, T2DM, cardiovascular diseases, inflmmation, metabolic syndrome and many other diseases. In the literature, it is frequently observed that circulating chemerin levels are high in individuals with obese and metabolic syndrome. In this review, chemerinin is associated with the effcts of obesity and the metabolic syndrome, as well as lessstudied inflmmation, polycystic ovarian syndrome and other metabolic effcts.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Lehr S., Hartwig S., Sell H. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin Appl 2012; 6(1-2):91-101.
2. Rourke JL., Dranse HJ, Sinal CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease. Obes Rev 2013;14(3):245-62.
3. Booth A., Magnuson A., Fouts J., et al. Adipose tissue, obesity and adipokines: role in cancer promotion. Horm Mol Biol Clin Investig 2015;21(1):57-74.
4. Mattern A., Zellmann T., Beck-Sickinger AG. Processing, signaling, and physiological function of chemerin. IUBMB Life 2014;66(1):19-26
5. Roh SG., Song SH., Choi KC. et al. Chemerin--a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 2007; 362(4):1013-8.
6. Dupont J., Pollet-Villard X., Reverchon M., Mellouk N., Levy R. Adipokines in human reproduction. Horm Mol Biol Clin Investig 2015;24(1):11- 24.
7. De Henau O., Degroot GN., Imbault V. et al. Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2. PLoS One 2016;11(10):e0164179.
8. Ernst MC., Sinal CJ. Chemerin: at the crossroads of inflmmation and obesity. Trends Endocrinol Metab 2010;21(11):660-7.
9. Roman AA, Parlee SD, Sinal CJ. Chemerin: a potential endocrine link between obesity and type 2 diabetes. Endocrine 2012;42(2):243-51.
10. Goralski KB., McCarthy TC., Hanniman EA. et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007;282(38):28175-88.
11. Piya MK., McTernan PG., Kumar S. Adipokine inflmmation and insulin resistance: the role of glucose, lipids and endotoxin. J Endocrinol 2013;216(1):T1-T15.
12. Chang SS., Eisenberg D., Zhao L. et al. Chemerin activation in human obesity. Obesity (Silver Spring) 2016;24(7):1522-9.
13. Bozaoglu K., Bolton K., McMillan J. et al. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 2007;148(10):4687-94.
14. Ress C., Tschoner A., Engl J. et al. Effct of bariatric surgery on circulating chemerin levels. Eur J Clin Invest 2010;40(3):277-80.
15. Chakaroun R., Raschpichler M., Kloting N. et al. Effcts of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism 2012;61(5):706-14.
16. Sell H., Divoux A., Poitou C. et al. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 2010;95(6):2892-6.
17. Fatima SS., Bozaoglu K., Rehman Ret al. Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PLoS One 2013; 8(2):e57113.
18. Thomas S., Kratzsch D., Schaab M. et al. Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa. Fertil Steril 2013;99(5):1256-63.e3.
19. Stejskal D., Karpisek M., Hanulovac Z. et al. Chemerın İs an İndependent marker of the metabolİc syndrome İn a caucasİan population. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2008;52(2):217–21.
20. Takahashi M., Takahashi Y., Takahashi K. et al. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 2008;582(5):573-8.
21. Bauer S., Bala M., Kopp A. et al. Adipocyte chemerin release is induced by insulin without being translated to higher levels in vivo. Eur J Clin Invest 2012;42(11):1213-20.
22. Wassink A., Olijhoek J., Visseren F. The metabolic syndrome metabolic changes with vascular Consequences. European Journal of Clinical Investigation 2007;37(1):8-17.
23. Li Y., Shi B., Li S. Association between serum chemerin concentrations and clinical indices in obesity or metabolic syndrome: a meta-analysis. PLoS One 2014;9(12):e113915.
24. Erdogan S., Yilmaz FM., Yazici O. et al. Inflmmation and chemerin in colorectal cancer. Tumour Biol 2016;37(5):6337-42.
25. Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, et al. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflmmatory flids. J Exp Med. 2003;198(7):977-85.
26. Fatima SS., Butt Z., Bader N. et al. Role of multifunctional Chemerin in obesity and preclinical diabetes. Obes Res Clin Pract 2015;9(5):507-12.
27. Weigert J., Obermeier F., Neumeier M. et al. Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn’s disease. Inflmm Bowel Dis 2010;6(4):630-7.
28. Shen W., Tian C., Chen H. et al. Oxidative stress mediates chemerin-induced autophagy in endothelial cells. Free Radic Biol Med 2013;55:73-82.
29. Jin CH., Yi KW., Ha YR. et al. Chemerin Expression in the Peritoneal Fluid, Serum, and Ovarian Endometrioma of Women with Endometriosis. Am J Reprod Immunol 2015;74(4):379-86.
30. Luangsay S., Wittamer V., Bondue B. et al. Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflmmatory activity of chemerin in a lung disease model. J Immunol 2009;183(10):6489- 99.
31. Lehrke M., Becker A., Greif M. et al. Chemerin is associated with markers of inflmmation and components of the metabolic syndrome but does not predict coronary atherosclerosis. Eur J Endocrinol 2009;161(2):339-44.
32. Guvenc Y., Var A., Goker A. et al. Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome. J Int Med Res 2016;44(4):796-805.
33. Kort DH., Kostolias A., Sullivan C. et al. Chemerin as a marker of body fat and insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol 2015;31(2):152-5.
34. Tan BK., Chen J., Farhatullah S. et al. Insulin and metformin regulate circulating and adipose tissue chemerin. Diabetes 2009;58(9):1971-7.
35. Guzel EC., Celik C., Abali R. et al. Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome. Gynecol Endocrinol 2014;30(6):419-22.
36. Guducu N. Serum Chemerin Levels In Polycystic Ovary Syndrome. Turkish Journal of Biochemistry 2015;40(2):157–62.
37. Rama D., Esendagli G., Guc D. Expression of chemokine-like receptor 1 (CMKLR1) on J744A.1 macrophages co-cultured with fibroblast and/ or tumor cells: modeling the inflence of microenvironment. Cell Immunol 2011;271(1):134- 40.
38. Wang C., Wu WK., Liu X. et al. Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. Peptides 2014;51:131-8.
39. Gu P., Jiang W., Lu B. et al. Chemerin is associated with inflmmatory markers and metabolic syndrome phenotypes in hypertension patients. Clin Exp Hypertens 2014;36(5):326-32.
40. Bonomini M., Pandolfi A. Chemerin in renal dysfunction and cardiovascular disease. Vascular Pharmacology 2016;77:28-34.
41. Pfau D., Bachmann A., Lossner U. et al. Serum levels of the adipokine chemerin in relation to renal function. Diabetes Care 2010;33(1):171-3.
42. Kostopoulos C., Spiroglou S., Varakis J., et al. Chemerin and CMKLR1 expression in human arteries and periadventitial fat. BMC Cardiovascular Disorders 2014;14(1):56.
43. Dong B, Ji W, Zhang Y. Elevated Serum Chemerin Levels are Associated with the Presence of Coronary Artery Disease in Patients with Metabolic Syndrome. Internal Medicine 2011;50(10):1093-7.
44. Zabel BA., Allen SJ., Kulig P. et al. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflmmatory cascades. J Biol Chem 2005;280(41):34661-6.

APA	ÇELİK M, SÖĞÜT M (2019). GÜNCEL BİR ADİPOKİN: CHEMERİN. , 98 - 104.
Chicago	ÇELİK Menşure Nur,SÖĞÜT Mehtap Ünlü GÜNCEL BİR ADİPOKİN: CHEMERİN. (2019): 98 - 104.
MLA	ÇELİK Menşure Nur,SÖĞÜT Mehtap Ünlü GÜNCEL BİR ADİPOKİN: CHEMERİN. , 2019, ss.98 - 104.
AMA	ÇELİK M,SÖĞÜT M GÜNCEL BİR ADİPOKİN: CHEMERİN. . 2019; 98 - 104.
Vancouver	ÇELİK M,SÖĞÜT M GÜNCEL BİR ADİPOKİN: CHEMERİN. . 2019; 98 - 104.
IEEE	ÇELİK M,SÖĞÜT M "GÜNCEL BİR ADİPOKİN: CHEMERİN." , ss.98 - 104, 2019.
ISNAD	ÇELİK, Menşure Nur - SÖĞÜT, Mehtap Ünlü. "GÜNCEL BİR ADİPOKİN: CHEMERİN". (2019), 98-104.

APA	ÇELİK M, SÖĞÜT M (2019). GÜNCEL BİR ADİPOKİN: CHEMERİN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 20(2), 98 - 104.
Chicago	ÇELİK Menşure Nur,SÖĞÜT Mehtap Ünlü GÜNCEL BİR ADİPOKİN: CHEMERİN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 20, no.2 (2019): 98 - 104.
MLA	ÇELİK Menşure Nur,SÖĞÜT Mehtap Ünlü GÜNCEL BİR ADİPOKİN: CHEMERİN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, vol.20, no.2, 2019, ss.98 - 104.
AMA	ÇELİK M,SÖĞÜT M GÜNCEL BİR ADİPOKİN: CHEMERİN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2019; 20(2): 98 - 104.
Vancouver	ÇELİK M,SÖĞÜT M GÜNCEL BİR ADİPOKİN: CHEMERİN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2019; 20(2): 98 - 104.
IEEE	ÇELİK M,SÖĞÜT M "GÜNCEL BİR ADİPOKİN: CHEMERİN." Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 20, ss.98 - 104, 2019.
ISNAD	ÇELİK, Menşure Nur - SÖĞÜT, Mehtap Ünlü. "GÜNCEL BİR ADİPOKİN: CHEMERİN". Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 20/2 (2019), 98-104.