TY  - JOUR
TI  - Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm
AB  - In this study, we used methanolic extract of Morinda citrifolia Linn. fruit (MMC) in order to find its effectagainst ethanol seeking behavior in a modified mouse runway paradigm. During conditioning/acquisition animalswere treated with accelerated doses of ethanol (0.5-4 g/kg, i.p.) for 5 days (Day 1- Day 5). Then, ethanol seekingbehavior was assessed on Day 6 (postconditioning test). Ethanol seeking behavior was confirmed in ethanol controlgroup in which the run time to reach the target box was significantly decreased. The test drug MMC (1, 3, and 5 g/kg,p.o.) caused a significant reversal of the ethanol seeking behavior by increasing the run time to reach the goal box asseen with the reference drug acamprosate (ACAM; 300 mg/kg, p.o.) in mice. After postconditioning test, nonrewardedabolishment assays were performed for a period of five days (Day 7 –Day 11). After 5 days of abolishment(abstinence), a priming dose of ethanol (the highest dose at 1/5th portion applied in control (i.e. 0.8 g/kg, i.p.)) inhouse cage significantly reinstated the ethanol-seeking behavior. Interestingly, MMC at a higher dose (5 g/kg, p.o.)showed significant halt on ethanol-induced reinstatement in mice as shown with the reference drug ACAM (300mg/kg, p.o.). The outcome of this study reveals that MMC alleviated ethanol seeking behaviour in modified mouserunway paradigm and it could be effectively used to treat alcohol dependence.
AU  - Pandy, Vijayapandi
AU  - Khan, Yasmin
DO  - 10.35333/jrp.2020.218
PY  - 2020
JO  - Journal of research in pharmacy (online)
VL  - 24
IS  - 5
SN  - 2630-6344
SP  - 632
EP  - 639
DB  - TRDizin
UR  - http://search/yayin/detay/361659
ER  -