TY  - JOUR
TI  - Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors
AB  - A series of new 1,3,4-oxadizole derivatives containing thioether group, has been synthesized to investigate their mPGES-1 inhibitory activities. The synthesized compounds were also evaluated for their anticancer and COX-1/2 inhibitory activities. All compounds were checked for their purity using TLC and HPLC analyses. The melting points, elemental analysis, FT-IR, 1H-/13C-NMR and LR-MS data were utilized for structural characterization.The most potent derivative was 2-[5-{[2-methyl-5-(propan-2-yl)phenoxy]methyl}-1,3,4-oxadiazol-2-yl)sulphanyl]-1-(phenyl)ethan-1-one 3a, which showed inhibitory activity against mPGES-1 with an IC50 of 4.95 μM. Docking studies with mPGES-1 and COX-1/2 enzymes revealed their affinity and potential binding mechanism for the testedcompounds.
AU  - ELMEZAYEN, Ammar
AU  - DING, Kai
AU  - ZHAN, Chang-Guo
AU  - YELEKÇİ, Kemal
AU  - Bingöl Özakpınar, Özlem
AU  - DURACIK, Merve
AU  - ERENSOY, Gizem
AU  - Küçükgüzel, İlkay
DO  - 10.35333/jrp.2020.187
PY  - 2020
JO  - Journal of research in pharmacy (online)
VL  - 24
IS  - 4
SN  - 2630-6344
SP  - 436
EP  - 451
DB  - TRDizin
UR  - http://search/yayin/detay/362158
ER  -