TY  - JOUR
TI  - Screening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests
AB  - Objectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with differentcut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment.Patients and methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12.4±3.9 years; range, 6 to 18 years)diagnosed with immune-mediated inflammatory diseases (IMIDs) evaluated with TST and T-SPOT.TB for screening LTBI both prior to and at the sixthmonth of treatment with anti-TNF agents. Coherence between two tests was analyzed for TST cut-off values suggested by the local guidelines andalso for different possible cut-off values of TST.Results: Tuberculin skin test was positive (≥5 mm) in 28.1% (n=16) of patients in the screening prior to treatment and in 33.3% (n=19) at the sixthmonth of treatment. T-SPOT.TB test was positive in 8.8% (n=5) of patients both prior to and at the sixth month of treatment. Coherence between twotests was poor or fair when compared with all possible TST cut-off values both prior to and at the sixth month of anti-TNF therapy.Conclusion: Our results show poor coherence between T-SPOT.TB and TST for all possible cut-off values of TST. Thus, using both tests would bebeneficial in screening LTBI until further studies bring new evidence on the subject.
AU  - Atabek, Ayse Ayzit
AU  - Kockar Kizilirmak, Tuba
AU  - OKTEM, SEDAT
AU  - Kasapcopur, Ozgur
AU  - Goktas, Safak
AU  - Senol, Ebru
AU  - cokugras, Haluk Cezmi
AU  - PEKCAN, SEVGI
AU  - GİRİT, saniye
DO  - 10.5606/ArchRheumatol.2020.7294
PY  - 2020
JO  - Archives of Rheumatology
VL  - 35
IS  - 1
SN  - 2148-5046
SP  - 20
EP  - 28
DB  - TRDizin
UR  - http://search/yayin/detay/362304
ER  -