Superficial Musculo-Aponeurotic System (SMAS) is a network of collagen fibers, elastic fibers and fat interconnecting facial muscles anddermis. Subcutaneous morphology of face is more organized than subcutaneous layer of any part of body. SMAS has distinctive features inforehead, parotid region, zygomatic region, temporal region, cheek, infraorbital region, nasolabial fold, and lower lip. Because SMAS is a keyfeature for either percutaneous and surgical aesthetic interventions, neurovascular structure embedded in this tissue must be well known.Radiologic views were enrolled from the archive system of radiology department. Images of 50 patients were randomly selected. (29 ale, 21female). Age width of the participants was in between 18 and 78 years (mean age 40.34± 15.32).Thickness of SMAS for each region is measured. Continuity of the tissue was followed between the junctions of the regions in a propersequence with MR images. Thickness of SMAS in the zygomatic region was measured in 50 patients and mean value was 0.12 mm. Left andright side measures were compared between genders and no statistical difference between gender groups was found. Correlation betweenmeasures and age was analyzed statistically and no correlation was found.A radiologically and clinically neglected tissue: SMAS deserves more attention because of its continuous course interconnecting distinctregions of face and acting as a functional unit for the expressions. Age and gender related changes in SMAS morphology studied in healthyindividuals by means of radiology provides an important contribution to the literature.