Na+ channel blocker enhances metformin effects on neuroblastoma cell line

HACİMUFTUOGLU, Ahmet; YİLMAZ, Aysegul; TAGHİZADEHGHALEHJOUGHİ, Ali

doi:10.5455/medscience.2019.08.9038

Na+ channel blocker enhances metformin effects on neuroblastoma cell line

Ali TAGHİZADEHGHALEHJOUGHİ, (Ataturk Üniversitesi, Tıp Fakültesi, Medikal Farmakoloji, Erzurum,Türkiye)

Ahmet HACİMUFTUOGLU, (Ataturk Üniversitesi, Tıp Fakültesi, Medikal Farmakoloji, Erzurum,Türkiye)

Aysegul YİLMAZ (Ataturk Üniversitesi, Tıp Fakültesi, Medikal Farmakoloji, Erzurum,Türkiye)

Medicine Science

3 0

Yıl: 2019 Cilt: 8 Sayı: 3 Sayfa Aralığı: 636 - 640 Metin Dili: İngilizce DOI: 10.5455/medscience.2019.08.9038 İndeks Tarihi: 15-10-2020

Na+ channel blocker enhances metformin effects on neuroblastoma cell line

Öz:

The aim of the current study is the evaluation of valproic acid and Metformin antitumor effect on neuroblastoma (SH-SY5Y) and answer the question, is valproic acid (VPA) increase Metformin (MET) antitumor effect on the SH-SY5Y cancer cell line or not. The SH-SY5Y cell line was grown in culture medium. A different dose of MET and VPA were applied to SH-SY5Y cancer cell lines for 24 hrs. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell viability, Annexin-V-FITC apoptosis, Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) tests were done 24 hours after drug administration. As a result of the tests, the combination of MET and VPA reduced cancer cell viability compared with the control group (p<0.001). According to our result, valproic acid increased metformin antitumor effects more than metformin alone

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TAGHİZADEHGHALEHJOUGHİ A, HACİMUFTUOGLU A, YİLMAZ A (2019). Na+ channel blocker enhances metformin effects on neuroblastoma cell line. , 636 - 640. 10.5455/medscience.2019.08.9038
Chicago	TAGHİZADEHGHALEHJOUGHİ Ali,HACİMUFTUOGLU Ahmet,YİLMAZ Aysegul Na+ channel blocker enhances metformin effects on neuroblastoma cell line. (2019): 636 - 640. 10.5455/medscience.2019.08.9038
MLA	TAGHİZADEHGHALEHJOUGHİ Ali,HACİMUFTUOGLU Ahmet,YİLMAZ Aysegul Na+ channel blocker enhances metformin effects on neuroblastoma cell line. , 2019, ss.636 - 640. 10.5455/medscience.2019.08.9038
AMA	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A Na+ channel blocker enhances metformin effects on neuroblastoma cell line. . 2019; 636 - 640. 10.5455/medscience.2019.08.9038
Vancouver	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A Na+ channel blocker enhances metformin effects on neuroblastoma cell line. . 2019; 636 - 640. 10.5455/medscience.2019.08.9038
IEEE	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A "Na+ channel blocker enhances metformin effects on neuroblastoma cell line." , ss.636 - 640, 2019. 10.5455/medscience.2019.08.9038
ISNAD	TAGHİZADEHGHALEHJOUGHİ, Ali vd. "Na+ channel blocker enhances metformin effects on neuroblastoma cell line". (2019), 636-640. https://doi.org/10.5455/medscience.2019.08.9038

APA	TAGHİZADEHGHALEHJOUGHİ A, HACİMUFTUOGLU A, YİLMAZ A (2019). Na+ channel blocker enhances metformin effects on neuroblastoma cell line. Medicine Science, 8(3), 636 - 640. 10.5455/medscience.2019.08.9038
Chicago	TAGHİZADEHGHALEHJOUGHİ Ali,HACİMUFTUOGLU Ahmet,YİLMAZ Aysegul Na+ channel blocker enhances metformin effects on neuroblastoma cell line. Medicine Science 8, no.3 (2019): 636 - 640. 10.5455/medscience.2019.08.9038
MLA	TAGHİZADEHGHALEHJOUGHİ Ali,HACİMUFTUOGLU Ahmet,YİLMAZ Aysegul Na+ channel blocker enhances metformin effects on neuroblastoma cell line. Medicine Science, vol.8, no.3, 2019, ss.636 - 640. 10.5455/medscience.2019.08.9038
AMA	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A Na+ channel blocker enhances metformin effects on neuroblastoma cell line. Medicine Science. 2019; 8(3): 636 - 640. 10.5455/medscience.2019.08.9038
Vancouver	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A Na+ channel blocker enhances metformin effects on neuroblastoma cell line. Medicine Science. 2019; 8(3): 636 - 640. 10.5455/medscience.2019.08.9038
IEEE	TAGHİZADEHGHALEHJOUGHİ A,HACİMUFTUOGLU A,YİLMAZ A "Na+ channel blocker enhances metformin effects on neuroblastoma cell line." Medicine Science, 8, ss.636 - 640, 2019. 10.5455/medscience.2019.08.9038
ISNAD	TAGHİZADEHGHALEHJOUGHİ, Ali vd. "Na+ channel blocker enhances metformin effects on neuroblastoma cell line". Medicine Science 8/3 (2019), 636-640. https://doi.org/10.5455/medscience.2019.08.9038