Yıl: 2020 Cilt: 29 Sayı: 2 Sayfa Aralığı: 129 - 137 Metin Dili: Türkçe DOI: 10.17827/aktd.603432 İndeks Tarihi: 29-07-2022

Hidrojellerin Tıpta Uygulamaları

Öz:
Hidrojeller “Smart (akıllı)” yapılar olarak tanımlanan ilaç taşınım sistemleri, enjekte edilebilen polimer sistemleri, dokumühendisliği ve hücre enkapsülasyonu gibi tıpta yaygın olarak kullanılan polimerlerdir. Hidrojeller suyu yapılarındatutabilme özellikleri, yumuşak ve esnek yapıda olmaları ile canlı dokulara büyük benzerlik göstermektedirler. Toksisitesiolmayan, biyolojik olarak parçalanan ve biyolojik uyum gösterebilen yapıları sebebiyle hidrojellerin biyomalzeme olarakkullanılması giderek güvenli hale gelmektedir. Aynı zamanda hidrojellerin kontrollü serbest bırakma mekanizması, ilacınsalım hızını düzenleyen geleneksel dozaj yöntemleri karşısında birçok avantaj sağlamaktadır. Bu derlemede genel olarakyara örtüsünde, yanık, anevrizma tedavilerinde, kemik rejenerasyonunda, kardiyak doku onarım ve rejenerasyonunda,kontrollü ilaç salımında, kontakt lenslerde, glokom tedavisinde kullanılan ve biyolojik araştırmaları devam etmekte olanhidrojellerden bahsedilmektedir.
Anahtar Kelime:

Applications of Hydrogel in Medicine

Öz:
Hydrogels are defined as smart structures that are commonly used in medicine such as drug delivery systems, injectable polymer systems, tissue engineering and cell encapsulation. Hydrogels are very similar properties to living tissues due to ability to keep water in their own structures as well as soft and flexible structures. Due to their non-toxic, biodegradable and biocompatible structures, the use of hydrogels as biomaterials is becoming safer. Also the controlled release mechanism of hydrogels provides many advantages over conventional dosage methods that regulate the rate of release of the drug. In this review, hydrogels, which are generally used in wound dressing, burn treatment, aneurysm treatment, bone regeneration, cardiac tissue repair and regeneration, controlled drug release, contact lenses and glaucoma treatment are being discussed.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Ferreira NN, Ferreira LMB, CardosoVMO, Boni FI, Souza AL. Gremião MPD. Recent advances in smart hydrogels for biomedical applications: From self-assembly to functional approaches. Eur Polym J. 2018;99:117-33
  • Kabiri K, Zohuriaan J. Superabsorbent polymer materials: A review. Iran Polym J. 2008;17:451-77.
  • Lin CC, Metters AT. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58:1379–1408.
  • Sop ES, Doku genişletme amaçlı hidrojel sentezi, karakterizasyonu ve şişme kinetiği( Yüksek Lisans Tezi). Ankara, Hacettepe Üniversitesi. 2013.
  • Kishida A, Ikada Y, Hydrogels for biomedical and pharmaceutical applications, Polymeric Biomaterials, Revised and Expanded. 2nd ed(Eds S. Dumitriu):133-145. Marcel Dekker, Newyork, 2002.
  • Wichterle O, Lim D. Hydrophilic gels for biological use. Nature. 1960;185:117-8.
  • Sarsılmaz F, Sarsılmaz C. Ortopedide kullanılan polimer esaslı kompozit malzemeler. Dogu Anadolu Bolge Arastirmalari Derg. 2003;3:113-7.
  • Brahıma S. pH ve sıcaklığa duyarlı hidrojellerin sentezlenmesi ve ilaç salım davranışlarının modellenmesi(Yüksek Lisans Tezi). Malatya, İnönü Üniversitesi, 2016.
  • Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev. 2008;60:1638-49.
  • Ullah F, Othman MBH, Javed F, Ahmad Z, Akil HM. Classification, processing and application of hydrogel: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-33.
  • Ahmad EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015;6:105-21.
  • Pescosolido L, Vermonden T, Malda J, Censi R, Dhert WJA, Alhaique , Hennink WE, Matricardi P. In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications. Acta Biomater.2011;7:1627-33.
  • Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-46.
  • Chung HJ, Park TG. Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering. Nano Today. 2009;4:429-37.
  • Varaprasad K, Raghavendra GM, Jayaramudu T, Yallapu MM, Sadiku R. A mini review on hydrogels classification and recent developments in miscellaneous applications. Mater Sci Eng C Mater Biol Appl. 2017;79:958-71.
  • Hennink WE, Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev. 2002;54:13-36.
  • Ullah F, Othman MBH, Javed F, Ahmad Z, Akil H. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-33.
  • Satish CS, Satish KP, Shivakumar HG. Hydrogels as controlled drug delivery systems: Synthesis, crosslinking, water and drug transport mechanism. Indian J Pharm Sci. 2006;68:133-40.
  • Ganji F, Farahani EV. Hydrogels in controlled drug delivery systems. Iran Polym J. 2009;18:63-88.
  • Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnol Adv. 2014;32:449-61.
  • Javanbakht S, Shaabani A. Carboxymethyl cellulose-based oral delivery systems. Int J Biol Macromol. 2019;133:21-9.
  • Syed I, Garg S, Sarkar P. Entrapment of essential oils in hydrogels for biomedical applications. Polymeric Gels: Characterization, Properties and Biomedical Applications, 1st ed (Eds K. Pal, I Banerjee): 125-141. Woodhead Publishing, Cambridge, 2018.
  • Roy N, Saha N. PVP-based hydrogels: Synthesis, properties and applications. Hydrogel: Synthesis, Characterization and Applications, 1st ed (Eds FV. Camara, LJ. Ferreira ):227-252. Nova Science Publishers, Lancaster, 2012.
  • Burdick JA, Prestwich GD. Hyaluronic acid hydrogel for biomedical applications. Adv Mater. 2011;23:41-56.
  • Hamedi H, Moradi S, Hudson SM, Tonelli AE. Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohydr Polym. 2018;199:445-60.
  • Ragothaman M, Palanisamy T, Kalirajan C. Collagen–poly(dialdehyde) guar gum based porous 3D scaffolds immobilized with growth factor for tissue engineering applications. Carbohydr Polym. 2014;114:399-406.
  • Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J. 2015;65:252-67.
  • White PM, Lewis S, Gholkar A, Sellar R, Nahser H, Cognard C, Forrester L, Wardlaw JM. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms(HELPS): a randomised controlled trial. Lancet. 2011;377:1655-62.
  • Serafin Z, Leo GD, Palys A, Nowaczewska M, Beuth W, Sardanelli F. Follow-up of cerebral aneurysm embolization with hydrogel embolic system: Systematic review and meta-analysis. Eur J Radiol. 2015;84:1954-63.
  • Bai X, Gao M, Syed S, Zhuang J, Xu X, Zhang XQ. Bioactive hydrogels for bone regeneration. Bioact Mater. 2018;3:401-17.
  • Grigore ME Hydrogels for cardiac tissue repair and regeneration. J Cardiovasc Med (Hagerstown). 2017;4:49-57.
  • Mishra B, Upadhyay M, Reddy ASK, Vasant BG, Muthu MS. Hydrogels: An introduction to a controlled drug delivery device, synthesis and application in drug delivery and tissue engineering. Austin J Biomed Eng. 2017;4:1037-49.
  • Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-46.
  • Lloyd A.W., Faragher R.G., Denyer S.P., Ocular biomaterials and implants. Biomaterials. 2001;22:769-85.
  • Loh XJ, Lee TC, Ito Y. Hydrogels for biomedical applications. Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, 1st ed (Eds XJ Loh, OA Scherman) :167-209. Royal Society of Chemistry, San Diego, 2013.
  • Aranguez AG, Colligris B, Pintor J. Contact lenses: Promising devices for ocular drug delivery. J Ocul Pharmacol Ther. 2012;29:189-99.
APA Işık A, Dikmen N (2020). Hidrojellerin Tıpta Uygulamaları. , 129 - 137. 10.17827/aktd.603432
Chicago Işık Ayşe,Dikmen Nurten Hidrojellerin Tıpta Uygulamaları. (2020): 129 - 137. 10.17827/aktd.603432
MLA Işık Ayşe,Dikmen Nurten Hidrojellerin Tıpta Uygulamaları. , 2020, ss.129 - 137. 10.17827/aktd.603432
AMA Işık A,Dikmen N Hidrojellerin Tıpta Uygulamaları. . 2020; 129 - 137. 10.17827/aktd.603432
Vancouver Işık A,Dikmen N Hidrojellerin Tıpta Uygulamaları. . 2020; 129 - 137. 10.17827/aktd.603432
IEEE Işık A,Dikmen N "Hidrojellerin Tıpta Uygulamaları." , ss.129 - 137, 2020. 10.17827/aktd.603432
ISNAD Işık, Ayşe - Dikmen, Nurten. "Hidrojellerin Tıpta Uygulamaları". (2020), 129-137. https://doi.org/10.17827/aktd.603432
APA Işık A, Dikmen N (2020). Hidrojellerin Tıpta Uygulamaları. Arşiv Kaynak Tarama Dergisi, 29(2), 129 - 137. 10.17827/aktd.603432
Chicago Işık Ayşe,Dikmen Nurten Hidrojellerin Tıpta Uygulamaları. Arşiv Kaynak Tarama Dergisi 29, no.2 (2020): 129 - 137. 10.17827/aktd.603432
MLA Işık Ayşe,Dikmen Nurten Hidrojellerin Tıpta Uygulamaları. Arşiv Kaynak Tarama Dergisi, vol.29, no.2, 2020, ss.129 - 137. 10.17827/aktd.603432
AMA Işık A,Dikmen N Hidrojellerin Tıpta Uygulamaları. Arşiv Kaynak Tarama Dergisi. 2020; 29(2): 129 - 137. 10.17827/aktd.603432
Vancouver Işık A,Dikmen N Hidrojellerin Tıpta Uygulamaları. Arşiv Kaynak Tarama Dergisi. 2020; 29(2): 129 - 137. 10.17827/aktd.603432
IEEE Işık A,Dikmen N "Hidrojellerin Tıpta Uygulamaları." Arşiv Kaynak Tarama Dergisi, 29, ss.129 - 137, 2020. 10.17827/aktd.603432
ISNAD Işık, Ayşe - Dikmen, Nurten. "Hidrojellerin Tıpta Uygulamaları". Arşiv Kaynak Tarama Dergisi 29/2 (2020), 129-137. https://doi.org/10.17827/aktd.603432