Endometrial “Scratching” An update and overview of current research

Günther, Veronika; Maass, Nicolai; von Otte, Sören; Alkatout, Ibrahim

Endometrial “Scratching” An update and overview of current research

Veronika GUNTHER, (UKSH Campus Kiel, Clinic for Obstetrics and Gynecology, Kiel, Germany)

Sören Von OTTE, (University Fertility Center, Ambulanzzentrum des UKSH gGmbH, Kiel, Germany)

Nicolai MAASS, (UKSH Campus Kiel, Clinic for Obstetrics and Gynecology, Kiel, Germany)

İbrahim ALKATOUT (UKSH Campus Kiel, Clinic for Obstetrics and Gynecology, Kiel, Germany)

Journal of the Turkish-German Gynecological Association

2 0

Yıl: 2020 Cilt: 21 Sayı: 2 Sayfa Aralığı: 124 - 129 Metin Dili: İngilizce İndeks Tarihi: 16-10-2020

Endometrial “Scratching” An update and overview of current research

Öz:

About one in every six couples is affected by sterility. Assisted reproduction procedures are currently the treatment of choice for a number ofpatients who desire children. Many causes of sterility can be overcome with the aid of in vitro fertilization, but successful implantation of theembryos is the major limiting factor. Failure of implantation may occur repetitively. In the treatment of sterility, many approaches have been usedto overcome the barrier of implantation failure and improve the chances of successful nidation. Scratching the endometrium prior to embryotransfer has been suggested as one means of enhancing the likelihood of implantation. The current literature was examined to investigate ifthere was any possible benefit from endometrial scratching. The studies were divided according to whether the women suffered from recurrentimplantation failure or not. In summary, it was found that unselected subfertile women generally benefit less from endometrial scratching, butscratching appears to be successful in women who have experienced repeated implantation failure. Although the heterogeneous body of dataon the subject deserves further clarification. The latest data presented at “European Society of Human Reproduction and Embryology” 2018 inBarcelona suggested that the method should be abandoned. (J Turk Ger Gynecol Assoc 2020; 21: 124-9)

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. ESHRE, A., Fact Sheet July 2014. https://http://www.eshre.eu/ guidelines-and-legal/art-fact-sheet.aspx., Accessed 22 December 2015.
2. Narvekar SA, Gupta N, Shetty N, Kottur A, Srinivas MS, Rao KA. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study. J Hum Reprod Sci 2010; 3: 15-9.
3. Dekel N, Gnainsky Y, Granot I, Racicot K, Mor G. The role of inflammation for a successful implantation. Am J Reprod Immunol 2014; 72: 141-7.
4. Tan BK, Vandekerckhove P, Kennedy R, Keay SD. Investigation and current management of recurrent IVF treatment failure in the UK. BJOG 2005; 112: 773-80.
5. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online 2014; 28: 14-38.
6. Vercellini P, Somigliana E, ViganoP, Abbiati A, Barbara G, Crosignani PG. Surgery for endometriosis-associated infertility: a pragmatic approach. Hum Reprod 2009; 24: 254-69.
7. Alkatout I, Mettler L, Beteta C, Hedderich J, Jonat W, Schollmeyer T. Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial. J Minim Invasive Gynecol 2013; 20: 473-81.
8. Mettler L, Ruprai R, Alkatout I. Impact of medical and surgical treatment of endometriosis on the cure of endometriosis and pain. Biomed Res Int 2014; 2014: 264653.
9. Loeb L, The experimental proof changes in the uterine decidua of guinea pig after mating. Zentralbl Allg Pathol 1907; 18: 563-5.
10. Barash A, Dekel E, Feildust S, Segal I, Schectman Ei Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79: 1317-22.
11. Li R, Hao G. Local injury to the endometrium: its effect on implantation. Curr Opin Obstet Gynecol 2009; 21: 236-9.
12. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94: 2030-6.
13. Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30: 111-23.
14. Lass A, Peat D, Brinsden P. Histological evaluation of endometrium on the day of oocyte retrieval after gonadotrophin-releasing hormone agonist-follicle stimulating hormone ovulation induction for in-vitro fertilization. Hum Reprod 1998; 13: 3203-5.
15. Ubaldi F, Bourgain C, Tournaye H, Smitz J, Van Steirteghem A, Devroey P. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertil Steril 1997; 67: 521-6.
16. Fatemi HM, Popovic-Todorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod Biomed Online 2013; 27: 530-8.
17. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25: 561-71.
18. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49: 677-80.
19. Ko JK, Ng EN. Scratching and IVF: any role? Curr Opin Obstet Gynecol 2016; 28: 178-83.
20. Shohayeb A, El-Khayat W. Does a single endometrial biopsy regimen (S-EBR) improve ICSI outcome in patients with repeated implantation failure? A randomised controlled trial. Eur J Obstet Gynecol Reprod Biol 2012; 164: 176-9.
21. Singh N, Toshyan V, Kumar S, Vanamail P, Madhu M. Does endometrial injury enhances implantation in recurrent in-vitro fertilization failures? A prospective randomized control study from tertiary care center. J Hum Reprod Sci 2015; 8: 218-23.
22. Kumbak B, Şahin L, Özkan S, Atılgan R. Impact of luteal phase hysteroscopy and concurrent endometrial biopsy on subsequent IVF cycle outcome. Arch Gynecol Obstet 2014; 290: 369-74.
23. Baum M, Yerushalmi GM, Maman E, Kedem A, Machtinger R, Hourvitz A, et al. Does local injury to the endometrium before IVF cycle really affect treatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28: 933-6.
24. Gibreel A, El-Adawi N, Elgindy E, Al-Inany H, Allakany N, Tournaye H. Endometrial scratching for women with previous IVF failure undergoing IVF treatment. Gynecol Endocrinol 2015; 31: 313-6.
25. Nastri CO, Lensen SF, Gibreel A, Raine-Fenning N, Ferriani RA, Bhattacharya S, et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2015: CD009517.
26. Zhou L, Li R, Wang R, Huang H, Zhong K. Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril 2008; 89: 1166-76.
27. Nastri CO, Ferriani RA, Raine-Fenning N, Martins WP. Endometrial scratching performed in the non-transfer cycle and outcome of assisted reproduction: a randomized controlled trial. Ultrasound Obstet Gynecol 2013; 42: 375-82.
28. Guven S, Kart C, Unsal MA, Yildirim O, Odaci E, Ylug E. Endometrial injury may increase the clinical pregnancy rate in normoresponders undergoing long agonist protocol ICSI cycles with single embryo transfer. Eur J Obstet Gynecol Reprod Biol 2014; 173: 58-62.
29. Karimzade MA, Oskouian H, Ahmadi S, Oskouian L. Local injury to the endometrium on the day of oocyte retrieval has a negative impact on implantation in assisted reproductive cycles: a randomized controlled trial. Arch Gynecol Obstet 2010; 281: 499- 503.
30. Safdarian L, Movahedi S, Aleyasine A, Aghahosaini M, Fallah P, Rezaiian Z. Local injury to the endometrium does not improve the implantation rate in good responder patients undergoing in-vitro fertilization. Iran J Reprod Med 2011; 9: 285-8.
31. Yeung TWY, Chai J, Wun Li RH, Lee VCY, Chung Ho P, Yu Ng EH. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod 2014; 29: 2474-81.
32. Levin D, Hasson J, Cohen A, Or Y, Ata B, Barzilay L, et al. The effect of endometrial injury on implantation and clinical pregnancy rates. Gynecol Endocrinol 2017: 1-4.
33. Lensen SO, Armstrong D, Napier S, Sadler E, Hennes L, Stadelmann A, et al. Endometrial scratching by pipelle biopsy in IVF (the PIP study): A pragmatic randomised controlled trial. ESHRE, Barcelona 2018, 34. annual conference, 2018. Abstract O-139.
34. Lensen S, Osavlyuk D, Armstrong S, Stadelmann C, Hennes A, Napier E, et al. A Randomized Trial of Endometrial Scratching before In Vitro Fertilization. N Engl J Med 2019; 380: 325-34.

APA	Günther V, von Otte S, Maass N, Alkatout I (2020). Endometrial “Scratching” An update and overview of current research. , 124 - 129.
Chicago	Günther Veronika,von Otte Sören,Maass Nicolai,Alkatout Ibrahim Endometrial “Scratching” An update and overview of current research. (2020): 124 - 129.
MLA	Günther Veronika,von Otte Sören,Maass Nicolai,Alkatout Ibrahim Endometrial “Scratching” An update and overview of current research. , 2020, ss.124 - 129.
AMA	Günther V,von Otte S,Maass N,Alkatout I Endometrial “Scratching” An update and overview of current research. . 2020; 124 - 129.
Vancouver	Günther V,von Otte S,Maass N,Alkatout I Endometrial “Scratching” An update and overview of current research. . 2020; 124 - 129.
IEEE	Günther V,von Otte S,Maass N,Alkatout I "Endometrial “Scratching” An update and overview of current research." , ss.124 - 129, 2020.
ISNAD	Günther, Veronika vd. "Endometrial “Scratching” An update and overview of current research". (2020), 124-129.

APA	Günther V, von Otte S, Maass N, Alkatout I (2020). Endometrial “Scratching” An update and overview of current research. Journal of the Turkish-German Gynecological Association, 21(2), 124 - 129.
Chicago	Günther Veronika,von Otte Sören,Maass Nicolai,Alkatout Ibrahim Endometrial “Scratching” An update and overview of current research. Journal of the Turkish-German Gynecological Association 21, no.2 (2020): 124 - 129.
MLA	Günther Veronika,von Otte Sören,Maass Nicolai,Alkatout Ibrahim Endometrial “Scratching” An update and overview of current research. Journal of the Turkish-German Gynecological Association, vol.21, no.2, 2020, ss.124 - 129.
AMA	Günther V,von Otte S,Maass N,Alkatout I Endometrial “Scratching” An update and overview of current research. Journal of the Turkish-German Gynecological Association. 2020; 21(2): 124 - 129.
Vancouver	Günther V,von Otte S,Maass N,Alkatout I Endometrial “Scratching” An update and overview of current research. Journal of the Turkish-German Gynecological Association. 2020; 21(2): 124 - 129.
IEEE	Günther V,von Otte S,Maass N,Alkatout I "Endometrial “Scratching” An update and overview of current research." Journal of the Turkish-German Gynecological Association, 21, ss.124 - 129, 2020.
ISNAD	Günther, Veronika vd. "Endometrial “Scratching” An update and overview of current research". Journal of the Turkish-German Gynecological Association 21/2 (2020), 124-129.