A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience

Yıl: 2019 Cilt: 18 Sayı: 4 Sayfa Aralığı: 143 - 148 Metin Dili: İngilizce DOI: 10.4274/uob.galenos.2019.1284 İndeks Tarihi: 18-10-2020

A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience

Öz:
GCT (TGCT) relapse or become refractory after first-line therapy and optimal treatment for this group is not very well defined.Materials and Methods: We presented the analysis of the efficacy of high-dose chemotherapy and peripheral-blood stem-cell transplantation inpatients treated between 2016 and 2019. Five patients with five autologous stem-cell transplantations (ASCT) were analyzed retrospectively. Allpatients were treated with bleomycin, etoposide, cisplatin as first-line therapy and paclitaxel, ifosfamide, cisplatin was given as salvage chemotherapy.Stem–cell collection was performed with granulocyte stimulating factor. ASCT was performed with carboplatin (700 mg/m2) and etoposide (750 mg/m2). The results were provided as median (min-max).Results: After ASCT, all patients were in complete remission (CR). The follow-up after ASCT was 12 months. At the 12-month follow-up, four patientswere still alive and in CR, and only one patient died at 6th month after ASCT due to recurrence. Grade 2/4 toxicities were observed in five patients.Only one patient died due to complications of transplantation.Conclusion: Although the number of the patients in this study was limited, ASCT seemed to be a safe and effective treatment modality in recurrentrefractory non-seminomatous TGCT, and treatment-related mortality was very low in this heavily pretreated group.
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APA IZMIR GUNER S, GUNER E (2019). A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. , 143 - 148. 10.4274/uob.galenos.2019.1284
Chicago IZMIR GUNER SEBNEM,GUNER EKREM A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. (2019): 143 - 148. 10.4274/uob.galenos.2019.1284
MLA IZMIR GUNER SEBNEM,GUNER EKREM A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. , 2019, ss.143 - 148. 10.4274/uob.galenos.2019.1284
AMA IZMIR GUNER S,GUNER E A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. . 2019; 143 - 148. 10.4274/uob.galenos.2019.1284
Vancouver IZMIR GUNER S,GUNER E A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. . 2019; 143 - 148. 10.4274/uob.galenos.2019.1284
IEEE IZMIR GUNER S,GUNER E "A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience." , ss.143 - 148, 2019. 10.4274/uob.galenos.2019.1284
ISNAD IZMIR GUNER, SEBNEM - GUNER, EKREM. "A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience". (2019), 143-148. https://doi.org/10.4274/uob.galenos.2019.1284
APA IZMIR GUNER S, GUNER E (2019). A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. Üroonkoloji Bülteni, 18(4), 143 - 148. 10.4274/uob.galenos.2019.1284
Chicago IZMIR GUNER SEBNEM,GUNER EKREM A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. Üroonkoloji Bülteni 18, no.4 (2019): 143 - 148. 10.4274/uob.galenos.2019.1284
MLA IZMIR GUNER SEBNEM,GUNER EKREM A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. Üroonkoloji Bülteni, vol.18, no.4, 2019, ss.143 - 148. 10.4274/uob.galenos.2019.1284
AMA IZMIR GUNER S,GUNER E A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. Üroonkoloji Bülteni. 2019; 18(4): 143 - 148. 10.4274/uob.galenos.2019.1284
Vancouver IZMIR GUNER S,GUNER E A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience. Üroonkoloji Bülteni. 2019; 18(4): 143 - 148. 10.4274/uob.galenos.2019.1284
IEEE IZMIR GUNER S,GUNER E "A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience." Üroonkoloji Bülteni, 18, ss.143 - 148, 2019. 10.4274/uob.galenos.2019.1284
ISNAD IZMIR GUNER, SEBNEM - GUNER, EKREM. "A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience". Üroonkoloji Bülteni 18/4 (2019), 143-148. https://doi.org/10.4274/uob.galenos.2019.1284