Effects of sugammadex on ischemia reperfusion in a rat extremity model
Yıl: 2020 Cilt: 26 Sayı: 4 Sayfa Aralığı: 509 - 516 Metin Dili: İngilizce DOI: 10.14744/tjtes.2019.12524 İndeks Tarihi: 20-10-2020
Effects of sugammadex on ischemia reperfusion in a rat extremity model
Öz: BACKGROUND: The hypothesis of our study is that sugammadex has protective efficacy against ischemia-reperfusion (I/R) injuryin rats.METHODS: Our study included 28 male Wistar Albino rats. The rats were assigned to four groups. The sham group had no procedureother than anesthesia administration. The control group received three hours of ischemia and 24 hours of reperfusion. TheSgdx4 group received 4 mg/kg, and the Sgdx16 group received 16 mg/kg sugammadex intravenously, and then, reperfusion was applied.Histopathological investigation, and serum creatine kinase (CK), lactate dehydrogenase (LDH), and serum and tissue malondialdehyde(MDA) and superoxide dismutase (SOD) analyses were performed.RESULTS: When the sham group and the control group were compared, there were statistically significant differences histopathologically(p<0.01). There was no significant difference between the Sgdx4 group compared with the sham and control groups histopathologically(p>0.01). There was a significant difference between the Sgdx16 group and the sham group histopathologically (p<0.01). Therewere significant differences between the sham and control groups concerning CK and LDH levels (p<0.01). There was a significantdifference in the levels of CK between the control group and Sgdx4 group and in the levels of CK and LDH between the control groupand Sgdx16 group (p<0.01).CONCLUSION: In our study, we examined the histological and biochemical protective effects of 4 mg/kg sugammadex on unilaterallower extremity I/R injury in rats. The findings suggest that a 4 mg/kg dose of sugammadex was more effective than a 16 mg/kg dose.
Anahtar Kelime: Sıçan ekstremite modelinde iskemi reperfüzyon üzerine sugammadeks’in etkisi
Öz: AMAÇ: Çalışmamızın hipotezi, sugammadeks’in sıçanlarda iskemi reperfüzyon (İ/R) hasarına karşı koruyucu etkinliğe sahip olmasıdır. GEREÇ VE YÖNTEM: Çalışmaya 28 erkek Wistar Albino sıçanı dahil edildi. Sıçanlar dört gruba ayrıldı. Sham grubuna anestezi uygulaması dışında bir girişim uygulanmadı. Kontrol grubuna 3 saat iskemi ve 24 saat reperfüzyon uygulandı. Sgdks4 grubu ve Sgdks 16 grubu, intravenöz olarak sırasıyla 4 mg/kg ve 16 mg/kg sugammadeks aldı ve ardından reperfüzyon uygulandı. Histopatolojik inceleme ve serum kreatin kinaz (CK), laktat dehidrojenaz (LDH), serum ve doku malondialdehid (MDA) ve süperoksit dismutaz (SOD) analizleri yapıldı. BULGULAR: Sham grubu ve kontrol grubu karşılaştırıldığında, histopatolojik olarak istatistiksel olarak anlamlı farklılıklar vardı (p<0.01). Sgdks4 grubu ile sham ve kontrol grupları arasında histopatolojik olarak anlamlı fark yoktu (p>0.01). Sgdks16 grubu ile sham grubu arasında histopatolojik olarak anlamlı bir fark vardı (p<0.01). Sham ve kontrol grupları arasında CK ve LDH düzeyleri açısından anlamlı fark vardı (p<0.01). Kontrol grubu ile Sgdks4 grubu arasında CK düzeyleri arasında ve kontrol grubu ile Sgdks16 grubu arasında CK ve LDH düzeylerinde anlamlı bir fark vardı (p<0.01). TARTIŞMA: Çalışmamızda, sıçanlarda tek taraflı alt ekstremite İ/R yaralanması üzerine 4 mg/kg sugammadeks’in histolojik ve biyokimyasal koruyucu etkileri incelendi. 4 mg/kg sugammadeks dozunun 16 mg/kg dozdan daha etkili olduğunu görüldü.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ALAGÖZ A, Küçükgüçlü S, Boztas N, Hancı V, Yuluğ E, Şişman A (2020). Effects of sugammadex on ischemia reperfusion in a rat extremity model. , 509 - 516. 10.14744/tjtes.2019.12524 |
| Chicago | ALAGÖZ ALİ,Küçükgüçlü Semih,Boztas Nilay,Hancı Volkan,Yuluğ Esin,Şişman Ali Rıza Effects of sugammadex on ischemia reperfusion in a rat extremity model. (2020): 509 - 516. 10.14744/tjtes.2019.12524 |
| MLA | ALAGÖZ ALİ,Küçükgüçlü Semih,Boztas Nilay,Hancı Volkan,Yuluğ Esin,Şişman Ali Rıza Effects of sugammadex on ischemia reperfusion in a rat extremity model. , 2020, ss.509 - 516. 10.14744/tjtes.2019.12524 |
| AMA | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A Effects of sugammadex on ischemia reperfusion in a rat extremity model. . 2020; 509 - 516. 10.14744/tjtes.2019.12524 |
| Vancouver | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A Effects of sugammadex on ischemia reperfusion in a rat extremity model. . 2020; 509 - 516. 10.14744/tjtes.2019.12524 |
| IEEE | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A "Effects of sugammadex on ischemia reperfusion in a rat extremity model." , ss.509 - 516, 2020. 10.14744/tjtes.2019.12524 |
| ISNAD | ALAGÖZ, ALİ vd. "Effects of sugammadex on ischemia reperfusion in a rat extremity model". (2020), 509-516. https://doi.org/10.14744/tjtes.2019.12524 |
| APA | ALAGÖZ A, Küçükgüçlü S, Boztas N, Hancı V, Yuluğ E, Şişman A (2020). Effects of sugammadex on ischemia reperfusion in a rat extremity model. Ulusal Travma ve Acil Cerrahi Dergisi, 26(4), 509 - 516. 10.14744/tjtes.2019.12524 |
| Chicago | ALAGÖZ ALİ,Küçükgüçlü Semih,Boztas Nilay,Hancı Volkan,Yuluğ Esin,Şişman Ali Rıza Effects of sugammadex on ischemia reperfusion in a rat extremity model. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.4 (2020): 509 - 516. 10.14744/tjtes.2019.12524 |
| MLA | ALAGÖZ ALİ,Küçükgüçlü Semih,Boztas Nilay,Hancı Volkan,Yuluğ Esin,Şişman Ali Rıza Effects of sugammadex on ischemia reperfusion in a rat extremity model. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.4, 2020, ss.509 - 516. 10.14744/tjtes.2019.12524 |
| AMA | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A Effects of sugammadex on ischemia reperfusion in a rat extremity model. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 509 - 516. 10.14744/tjtes.2019.12524 |
| Vancouver | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A Effects of sugammadex on ischemia reperfusion in a rat extremity model. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 509 - 516. 10.14744/tjtes.2019.12524 |
| IEEE | ALAGÖZ A,Küçükgüçlü S,Boztas N,Hancı V,Yuluğ E,Şişman A "Effects of sugammadex on ischemia reperfusion in a rat extremity model." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.509 - 516, 2020. 10.14744/tjtes.2019.12524 |
| ISNAD | ALAGÖZ, ALİ vd. "Effects of sugammadex on ischemia reperfusion in a rat extremity model". Ulusal Travma ve Acil Cerrahi Dergisi 26/4 (2020), 509-516. https://doi.org/10.14744/tjtes.2019.12524 |
