Yıl: 2020 Cilt: 26 Sayı: 4 Sayfa Aralığı: 607 - 612 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.57375 İndeks Tarihi: 21-10-2020

Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?

Öz:
BACKGROUND: Hip fractures in the orthogeriatric population are a health problem that causes mortality and morbidity, withan increasing frequency. The present study aims to investigate whether the preoperative neutrophil-to-lymphocyte ratio (NLR) isa predictive value for the postoperative mortality risk in patients who underwent only proximal femoral nail (PFN) surgery due topertrochanteric fractures (PTF). To our knowledge, there is not any study conducted with a similar population in the litertaure.METHODS: Fifty-five patients who were operated on by two National Board-certified surgeons with the PFN method were includedin our retrospective study. The patients were divided into two groups. Group A included the patients who lost their lives within thepostoperative first year (n=13), while Group B included the survivors (n=42). Preoperative NLR data, demographic information, durationof hospitalization, postoperative intensive care requirements (ICU) and comorbid diseases of all patients were recorded.RESULTS: In our study with a maximum follow-up period of 27 months, no statistically significant difference was found between thegroups concerning age, gender, body mass index, preoperative American Society of Anesthesiologists scores (ASA), types of fractures,ICU requirements, duration of hospitalization (p>0.05). However, the NLR was significantly higher in Group A (p<0.01), with a cut-offvalue of 5.25, sensitivity of 84.6% and specificity of 78.6%.CONCLUSION: We believe that the preoperative NLR is a predictive variable for orthopedic surgeons in assessing the postoperativemortality risk in orthogeriatric patients who presented to the emergency room due to PTF and were planned to undergo PFN surgery.
Anahtar Kelime:

Ameliyat öncesi nötrofil-lenfosit oranı pertrokanterik kırık nedeniyle proksimal femoral çivi planlanan ortogeriatrik popülasyon için ameliyat sonrası mortaliteyi belirlemede kullanılabilecek ameliyat öncesi bir değer midir?

Öz:
AMAÇ: Ortogeriatrik popülasyonda kalça kırığı mortalite ve morbiditeye neden olan ve giderek sıklığı artan bir sağlık problemidir. Çalışmamızın amacı pertrokanterik kırık nedeniyle sadece proksimal femur çivi (PFÇ) cerrahi yöntemi ile tedavi edilmiş hastalarda; ameliyat öncesi nötrofil-lenfosit oranının (NLO) ameliyat sonrası mortalite riski için preditif bir değer olup olmadığını irdelemektir. Literatürde benzer popülasyonda planmış başka bir çalışma tespit edilememiştir. GEREÇ VE YÖNTEM: Geriye dönük olarak planlanan çalışmamıza ulusal ortopedi kurul sertifikalı iki cerrah tarafından PFÇ yöntemi ile ameliyatı gerçekleştirmiş 55 hasta alındı. Hastalar ameliyat sonrası ilk bir yıl hayatını kaybedenler (Grup A [n=13]) ve hayatta kalanlar (Grup B [n=42]) olarak iki gruba ayrıldı. Tüm hastaların ameliyat öncesi NLO değerleri, demografik bilgileri, hastanede kalış süreleri, ameliyat sonrası yoğun bakım (POYB) ihtiyaçları ve komorbid hastalıkları kayıt altına alındı. BULGULAR: En uzun hasta takip süresi 27 ay olan çalışmamız sonucunda her iki grup arasında; yaş, cinsiyet, vücut kitle indeksi, ameliyat öncesi American Society of Anesthesiologist (ASA) skorları, kırık tipleri, POYB ihtiyaçları, hastanede kalış süreleri ve hastaların acil servis başvurusundan ameliyathaneye alınmasına kadar geçen süre açısından anlamlı fark saptanmadı (p>0.05). Bununla birlikte anlamlı şekilde grup A hastalarında NLO değeri daha yüksek gözlenmiş (p<0.01), kestirim değer 5.25, sensitivitesi %84.6, spesifitesi %78.6 idi. TARTIŞMA: Ameliyat öncesi NLO değerinin ortopedik cerrahlar açısından; pertrokanterik kırık nedeniyle acil servise başvuran ve PFÇ cerrahisi planlanan ortogeriatrik hastaların ameliyat sonrası mortalite riski için prediktif değişkenlerden olacağını düşünmekteyiz.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Tang P, Hu F, Shen J, Zhang L, Zhang L. Proximal femoral nail antirotation versus hemiarthroplasty: a study for the treatment of intertrochanteric fractures. Injury 2012;43:876–81.
  • 2. Fahy AS, Wong F, Kunasingam K, Neen D, Dockery F, Ajuied A, et al. A review of hip fracture mortality—why and how does such a large proportion of these elderly patients die? Surgical Science 2014;5:227−32.
  • 3. Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 2012;43:676–85.
  • 4. del Prete F, Nizegorodcew T, Regazzoni P. Quantification of surgical trauma: comparison of conventional and minimally invasive surgical techniques for pertrochanteric fracture surgery based on markers of inflammation (interleukins). J Orthop Traumatol 2012;13:125–30.
  • 5. Esen E, Dur H, Ataoğlu MB, Ayanoğlu T, Turanlı S. Evaluation of proximal femoral nail-antirotation and cemented, bipolar hemiarthroplasty with calcar replacement in treatment of intertrochanteric femoral fractures in terms of mortality and morbidity ratios. Eklem Hastalik Cerrahisi 2017;28:35–40.
  • 6. Forget P, Moreau N, Engel H, Cornu O, Boland B, De Kock M, et al. The neutrophil-to-lymphocyte ratio (NLR) after surgery for hip fracture (HF). Arch Gerontol Geriatr 2015;60:366−71.
  • 7. Mosfeldt M, Pedersen OB, Riis T, Worm HO, Mark Sv, Jørgensen HL, et al. Value of routine blood tests for prediction of mortality risk in hip fracture patients. Acta Orthop 2012;83:31−5.
  • 8. Sedlář M, Kvasnička J, Krška Z, Tománková T, Linhart A. Early and subacute inflammatory response and long-term survival after hip trauma and surgery. Arch Gerontol Geriatr 2015;60:431–6.
  • 9. Sun T, Wang X, Liu Z, Chen X, Zhang J. Plasma concentrations of proand anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients. Injury 2011;42:707–13.
  • 10. Sedlár M, Kudrnová Z, Erhart D, Trca S, Kvasnicka J, Krska Z, et al. Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6). Arch Gerontol Geriatr 2010;51:e1−6.
  • 11. Fisher A, Srikusalanukul W, Fisher L, Smith P. The Neutrophil to Lymphocyte Ratio on Admission and Short-Term Outcomes in Orthogeriatric Patients. Int J Med Sci 2016;13:588–602.
  • 12. Temiz A, Ersözlü S. Admission neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture. Ulus Travma Acil Cerrahi Derg 2019;25:71–4.
  • 13. Forget P, Dillien P, Engel H, Cornu O, De Kock M, Yombi JC. Use of the neutrophil-to-lymphocyte ratio as a component of a score to predict postoperative mortality after surgery for hip fracture in elderly subjects. BMC Res Notes 2016;9:284.
  • 14. Andersen E, Jørgensen LG, Hededam LT. Evans’ classification of trochanteric fractures: an assessment of the interobserver and intraobserver reliability. Injury 1990;21:377–8.
  • 15. Copuroglu C, Ozcan M, Ciftdemir M, Unver KV, Saridogan K. Frequency of hip fractures admitted to a university hospital for the last ten years. Turkish J Geriatrics 2011;14:199−203.
  • 16. Aydin E, Kurtulus B, Celik B, Okan M. Treatment of intertrochanteric fractures in ambulatory elderly; bipolar hemiarthroplasty or proximal femoral nail? Turkish J Geriatrics 2016;19:42−9.
  • 17. Ergun M, Tolunay T, Bozkurt C, Kilicarslan K, Arslan AK. Comparison of clinical results of bipolar hemiarthroplasty for extracapsular and intracapsular hip fractures. Turkish J Geriatrics 2015;18:293−8.
  • 18. Kilicarslan K, Demirkale I, Cicek H, Mutlu T, Catma MF, Kayaalp C, et al. The mid-term results of partial hip arthroplasty for proximal femur fractures in elderly patients. [Article in Turkish] Turkish J Geriatrics 2010;13:13−7.
  • 19. Tüzün C, Tıkız C. Hip fractures in elderly and problems during rehabilitation. [Article in Turkish] Turkish J Geriatrics 2006;9:108−16.
  • 20. Sarıcaoğlu F, Akinci SB, Süheyla ATAY, Çağlar Ö, Aypar Ü. The effects of anesthesia techniques on postoperative mortality in elderly geriatric patients operated for femoral fractures. [Article in Turkish] Turkish J Geriatrics 2012;15:434−8.
  • 21. Daşar U. One-year retrospective evaluation of hip fracture patients aged more than 80 years and postoperatively monitored in the intensive care unit. Turkish J Geriatrics 2018;21:81−6.
  • 22. Temizel F, Uckun S, Kuzucuoğlu T, Arslan G, Cevik B. The effects of comorbidities on intensive care admission in elderly patients undergoing hip surgeries. Turkish J Geriatrics 2018;21:109−14.
  • 23. Mutlu T, Daşar U. Hip fracture surgery in patients older than 90 years: Evaluation of factors that affect 30-day mortality in a particularly risky group. Turkish J Geriatrics 2018;21:279−84.
APA ÖZBEK E, Ayanoğlu T, Olçar H, yalvaç e (2020). Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. , 607 - 612. 10.14744/tjtes.2020.57375
Chicago ÖZBEK Emre Anıl,Ayanoğlu Tacettin,Olçar Hacı ali,yalvaç eyyüp serdar Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. (2020): 607 - 612. 10.14744/tjtes.2020.57375
MLA ÖZBEK Emre Anıl,Ayanoğlu Tacettin,Olçar Hacı ali,yalvaç eyyüp serdar Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. , 2020, ss.607 - 612. 10.14744/tjtes.2020.57375
AMA ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. . 2020; 607 - 612. 10.14744/tjtes.2020.57375
Vancouver ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. . 2020; 607 - 612. 10.14744/tjtes.2020.57375
IEEE ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e "Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?." , ss.607 - 612, 2020. 10.14744/tjtes.2020.57375
ISNAD ÖZBEK, Emre Anıl vd. "Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?". (2020), 607-612. https://doi.org/10.14744/tjtes.2020.57375
APA ÖZBEK E, Ayanoğlu T, Olçar H, yalvaç e (2020). Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. Ulusal Travma ve Acil Cerrahi Dergisi, 26(4), 607 - 612. 10.14744/tjtes.2020.57375
Chicago ÖZBEK Emre Anıl,Ayanoğlu Tacettin,Olçar Hacı ali,yalvaç eyyüp serdar Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.4 (2020): 607 - 612. 10.14744/tjtes.2020.57375
MLA ÖZBEK Emre Anıl,Ayanoğlu Tacettin,Olçar Hacı ali,yalvaç eyyüp serdar Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.4, 2020, ss.607 - 612. 10.14744/tjtes.2020.57375
AMA ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 607 - 612. 10.14744/tjtes.2020.57375
Vancouver ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 607 - 612. 10.14744/tjtes.2020.57375
IEEE ÖZBEK E,Ayanoğlu T,Olçar H,yalvaç e "Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.607 - 612, 2020. 10.14744/tjtes.2020.57375
ISNAD ÖZBEK, Emre Anıl vd. "Is the preoperative neutrophil-to-lymphocyte ratio a predictive value for postoperative mortality in orthogeriatric patients who underwent proximal femoral nail surgery for pertrochanteric fractures?". Ulusal Travma ve Acil Cerrahi Dergisi 26/4 (2020), 607-612. https://doi.org/10.14744/tjtes.2020.57375